SCIENCEAres Lab Yeast Intron Database
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Search PubMed for Ares lab publications...or click here to obtain pdfs from the archive.
Intron Removal, Alternative Splicing, and GenomicsOur work centers on the mechanisms and regulation of splicing. Splicing is required
to remove intron sequences from pre-mRNA and create coding sequences for translation.
We study yeast, mouse, and human tissues and cells, as well as the malaria parasite
Plasmodium falciparum. We are generally interested in the structure and function of RNAs
that play important regulatory and catalytic roles.
We try to understand (1) the mechanism of action of the core components of the spliceosome,
in particular the snRNAs and their rearrangements during assembly of the spliceosome and
catalysis of the splicing reactions, (2) the regulation of alternative splicing at a mechanistic
level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the
coordinate regulation of splicing events in developing systems.
We are using microarrays that measure splicing, and are determining the effects of mutations
or other perturbations on splicing. Our goal is to develop a broad understanding of the role
of splicing in specific processes and biological events, at the level of genes whose function
and regulation at the level of splicing may be difficult to discern by traditional methods.
Oh yeah, and we like to surf.
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Principal Investigator Manny Ares |
Independent Investigators Rhonda Perriman, Melissa Cline |
Research Associate Haller Igel |
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Postdoctoral Research Fellows Kausik Chakrabarti, Megan Hall, Fereshteh Kenari (Valadkhan lab) |
Research Specialists Lily Shiue, John Paul Donohue |
Graduate Students Hongqing Du |
Our lab is
part of the Center for the Molecular
Biology of RNA, and the
Center for Biomolecular
Engineering.
SURF
 Navy Swell Predictions US Navy's Ocean Data
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