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   Intron Removal, Alternative Splicing, and Genomics
      Our work centers on the mechanisms and regulation of splicing. Splicing is required
   to remove intron sequences from pre-mRNA and create coding sequences for translation.

   We study yeast, mouse, and human tissues and cells. We are generally interested in the

   structure and function of RNAs that play important regulatory and catalytic roles.

     We try to understand (1) the mechanism of action of the core components of the spliceosome,
   in particular the snRNAs and their rearrangements during assembly of the spliceosome and
   catalysis of the splicing reactions, (2) the regulation of alternative splicing at a mechanistic
   level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the
   coordinate regulation of splicing events in developing systems.

     We are using microarrays that measure splicing, and are determining the effects of mutations
   or other perturbations on splicing. Our goal is to develop a broad understanding of the role
   of splicing in specific processes and biological events, at the level of genes whose function
   and regulation at the level of splicing may be difficult to discern by traditional methods.

   Interested graduate students should apply to the Program in Biomedical Science and Engineering (PBSE).

   Interested postdoctoral candidates should send a letter describing their interests and career plans.