WELCOME to the ARES LAB

...a molecular genetics lab at UC Santa Cruz.


    We study:
    Mechanism of action and regulation of the splicing machinery using genetic, genomic, and biochemical approaches
    Structure, function, and evolution of small RNAs

Research publications from PubMed

SCIENCE LINKS

Manny's Faculty Page

Links to Papers

ENTREZ

PUBMED

BLAST

UC Santa Cruz Genome Browser

SGD

Center for the Molecular Biology of  RNA

PBSE Graduate Program

Center for Biomolecular Engineering

Search PubMed for Ares lab publications...or click here to obtain pdfs from the archive.


Spliceosome Structure and Function, Alternative Splicing, and Genomics
Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation. We try to understand (1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions, (2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the coordinate regulation of splicing events in developing systems.

SURF LINKS


Steamer Lane Cam


Santa Cruz Tides


Monterey Bay Swell Map

California Swell Models