Find Ares lab publications at NCBI...or click here to obtain pdfs from the archive.

Spliceosome Structure and Function, Alternative Splicing, and Genomics
Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation. We try to understand (1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions, (2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the coordinate regulation of splicing events in developing systems.