# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 34 #b referenced loci : 32 #c annotated loci : 28 #d hyper-geometric : n 28 hgN 14129 #e k hgK Exp k p-value term description 13 2064 4 5.76302e-05 GO:0005515 protein binding 3 49 0 0.000120815 GO:0005789 endoplasmic reticulum membrane 3 50 0 0.000128357 GO:0042175 nuclear envelope-endoplasmic reticulum network 4 157 0.3 0.000244034 GO:0012505 endomembrane system 3 74 0.1 0.000411226 GO:0005516 calmodulin binding 3 102 0.2 0.00104957 GO:0045202 synapse 1 1 0 0.00198174 GO:0005955 calcineurin complex 1 1 0 0.00198174 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00198174 GO:0008089 anterograde axon cargo transport 1 1 0 0.00198174 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00198174 GO:0030325 adrenal gland development 6 749 1.4 0.00300471 GO:0016301 kinase activity 5 514 1 0.00306849 GO:0005856 cytoskeleton 1 2 0 0.00395969 GO:0008250 oligosaccharyl transferase complex 1 2 0 0.00395969 GO:0018196 peptidyl-asparagine modification 1 2 0 0.00395969 GO:0018279 N-linked glycosylation via asparagine 1 2 0 0.00395969 GO:0030517 negative regulation of axon extension 21 7041 13.9 0.00592791 GO:0005488 binding 1 3 0 0.00593386 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 1 4 0 0.00790426 GO:0007435 salivary gland morphogenesis 1 4 0 0.00790426 GO:0008088 axon cargo transport 1 4 0 0.00790426 GO:0045767 regulation of anti-apoptosis 2 73 0.1 0.00912502 GO:0005875 microtubule associated complex 3 222 0.4 0.00938487 GO:0008092 cytoskeletal protein binding 1 5 0 0.0098709 GO:0004576 oligosaccharyl transferase activity 1 5 0 0.0098709 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0098709 GO:0030516 regulation of axon extension 1 5 0 0.0098709 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0098709 GO:0030866 cortical actin cytoskeleton organization and biogenesis 11 2707 5.3 0.010735 GO:0005737 cytoplasm 1 6 0 0.0118338 GO:0001658 ureteric bud branching 1 6 0 0.0118338 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0118338 GO:0007431 salivary gland development 1 6 0 0.0118338 GO:0019894 kinesin binding 1 8 0 0.0157483 GO:0030659 cytoplasmic vesicle membrane 3 270 0.5 0.0158882 GO:0005578 extracellular matrix 1 10 0 0.0196478 GO:0001763 branching morphogenesis 1 11 0 0.021592 GO:0001657 ureteric bud development 1 11 0 0.021592 GO:0042472 inner ear morphogenesis 2 119 0.2 0.0230525 GO:0009790 embryonic development 1 12 0 0.0235324 GO:0006487 N-linked glycosylation 1 12 0 0.0235324 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0235324 GO:0042471 ear morphogenesis 2 122 0.2 0.0241466 GO:0007268 synaptic transmission 3 321 0.6 0.0250141 GO:0046907 intracellular transport 1 13 0 0.0254692 GO:0007548 sex differentiation 1 13 0 0.0254692 GO:0016998 cell wall catabolism 1 13 0 0.0254692 GO:0042493 response to drug 3 327 0.6 0.0262404 GO:0005783 endoplasmic reticulum 2 128 0.2 0.0263977 GO:0019226 transmission of nerve impulse 2 128 0.2 0.0263977 GO:0050905 neuromuscular physiological process 1 14 0 0.0274022 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0274022 GO:0012506 vesicle membrane 2 131 0.2 0.0275542 GO:0003774 motor activity 1 15 0 0.0293316 GO:0004722 protein serine/threonine phosphatase activity 1 15 0 0.0293316 GO:0008207 C21-steroid hormone metabolism 2 138 0.2 0.0303314 GO:0015630 microtubule cytoskeleton 1 16 0 0.0312572 GO:0030176 integral to endoplasmic reticulum membrane 1 17 0 0.0331792 GO:0016323 basolateral plasma membrane 1 18 0 0.0350975 GO:0001656 metanephros development 1 18 0 0.0350975 GO:0001822 kidney development 1 18 0 0.0350975 GO:0042446 hormone biosynthesis 2 151 0.2 0.0357712 GO:0007267 cell-cell signaling 1 19 0 0.0370121 GO:0001655 urogenital system development 1 19 0 0.0370121 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0370121 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0370121 GO:0030286 dynein complex 2 160 0.3 0.0397431 GO:0003779 actin binding 2 162 0.3 0.0406478 GO:0004713 protein-tyrosine kinase activity 1 21 0 0.0408304 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0 0.0408304 GO:0008287 protein serine/threonine phosphatase complex 4 669 1.3 0.0413499 GO:0006793 phosphorus metabolism 4 669 1.3 0.0413499 GO:0006796 phosphate metabolism 16 5553 11 0.0423274 GO:0005622 intracellular 1 22 0 0.0427341 GO:0046982 protein heterodimerization activity 1 24 0 0.0465304 GO:0003777 microtubule motor activity 1 24 0 0.0465304 GO:0006112 energy reserve metabolism 1 24 0 0.0465304 GO:0019933 cAMP-mediated signaling 6 1366 2.7 0.0477569 GO:0017076 purine nucleotide binding 1 25 0 0.0484232 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0484232 GO:0008017 microtubule binding 6 1374 2.7 0.0489187 GO:0000166 nucleotide binding 2 183 0.3 0.0506087 GO:0050879 organismal movement 1 27 0 0.0521978 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.0521978 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 1 28 0 0.0540797 GO:0019935 cyclic-nucleotide-mediated signaling 1 30 0 0.0578327 GO:0015631 tubulin binding 2 204 0.4 0.0613566 GO:0007010 cytoskeleton organization and biogenesis 1 32 0 0.0615713 GO:0018193 peptidyl-amino acid modification 2 218 0.4 0.0689214 GO:0006886 intracellular protein transport 1 37 0 0.0708554 GO:0007411 axon guidance 1 37 0 0.0708554 GO:0019932 second-messenger-mediated signaling 1 38 0 0.0727015 GO:0007018 microtubule-based movement 1 38 0 0.0727015 GO:0030705 cytoskeleton-dependent intracellular transport 3 496 0.9 0.0736732 GO:0004672 protein kinase activity 1 39 0 0.0745442 GO:0042445 hormone metabolism 5 1161 2.3 0.0750123 GO:0006464 protein modification 1 40 0 0.0763832 GO:0000165 MAPKKK cascade 1 41 0 0.0782188 GO:0006694 steroid biosynthesis 3 509 1 0.078298 GO:0006468 protein amino acid phosphorylation 13 4537 8.9 0.0802333 GO:0003824 catalytic activity 2 243 0.4 0.0831496 GO:0042578 phosphoric ester hydrolase activity 1 44 0 0.0837044 GO:0007420 brain development 2 244 0.4 0.0837366 GO:0006996 organelle organization and biogenesis 1 46 0 0.087344 GO:0006606 protein-nucleus import 1 46 0 0.087344 GO:0009795 embryonic morphogenesis 1 47 0 0.0891585 GO:0045211 postsynaptic membrane 1 1922 3.8 0.0899433 u GO:0007166 cell surface receptor linked signal transduction 2 259 0.5 0.0926955 GO:0007399 neurogenesis 1 51 0.1 0.096382 GO:0005941 unlocalized 3 559 1.1 0.0972532 GO:0016310 phosphorylation 3 586 1.1 0.108218 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 58 0.1 0.10889 GO:0005730 nucleolus 1 58 0.1 0.10889 GO:0006916 anti-apoptosis 2 286 0.5 0.109492 GO:0005525 GTP binding 2 286 0.5 0.109492 GO:0007028 cytoplasm organization and biogenesis 1 59 0.1 0.110664 GO:0005635 nuclear membrane 1 59 0.1 0.110664 GO:0008081 phosphoric diester hydrolase activity 1 60 0.1 0.112433 GO:0046983 protein dimerization activity 2 294 0.5 0.114619 GO:0019001 guanyl nucleotide binding 1 62 0.1 0.115963 GO:0007417 central nervous system development 1 63 0.1 0.117723 GO:0006486 protein amino acid glycosylation 1 63 0.1 0.117723 GO:0007409 axonogenesis 1 63 0.1 0.117723 GO:0030036 actin cytoskeleton organization and biogenesis 1 66 0.1 0.122981 GO:0043066 negative regulation of apoptosis 1 66 0.1 0.122981 GO:0043069 negative regulation of programmed cell death 1 67 0.1 0.124727 GO:0030029 actin filament-based process 1 69 0.1 0.12821 GO:0009101 glycoprotein biosynthesis 1 70 0.1 0.129946 GO:0006816 calcium ion transport 2 2359 4.6 0.130666 u GO:0004872 receptor activity 2 319 0.6 0.131033 GO:0050877 neurophysiological process 3 2958 5.8 0.132963 u GO:0004871 signal transducer activity 3 660 1.3 0.140619 GO:0007242 intracellular signaling cascade 1 77 0.1 0.142006 GO:0009100 glycoprotein metabolism 2 345 0.6 0.148658 GO:0004674 protein serine/threonine kinase activity 1 82 0.1 0.150521 GO:0008202 steroid metabolism 1 83 0.1 0.152215 GO:0007156 homophilic cell adhesion 1 84 0.1 0.153905 GO:0007017 microtubule-based process 1 85 0.1 0.155591 GO:0006913 nucleocytoplasmic transport 4 1067 2.1 0.157076 GO:0005524 ATP binding 2 358 0.7 0.157654 GO:0015031 protein transport 12 4555 9 0.158224 GO:0016020 membrane 3 698 1.3 0.158446 GO:0009887 organogenesis 1 1597 3.1 0.15865 u GO:0007186 G-protein coupled receptor protein signaling pathway 4 1078 2.1 0.161272 GO:0030554 adenyl nucleotide binding 1 91 0.1 0.165644 GO:0004867 serine-type endopeptidase inhibitor activity 1 93 0.1 0.168969 GO:0006605 protein targeting 3 723 1.4 0.170559 GO:0005576 extracellular 21 9173 18.1 0.179624 GO:0005623 cell 2 390 0.7 0.18023 GO:0007155 cell adhesion 1 106 0.2 0.190274 GO:0016477 cell migration 3 771 1.5 0.194572 GO:0016772 transferase activity, transferring phosphorus-containing groups 1 110 0.2 0.196722 GO:0015674 di-, tri-valent inorganic cation transport 1 110 0.2 0.196722 GO:0016758 transferase activity, transferring hexosyl groups 1 112 0.2 0.199928 GO:0016311 dephosphorylation 1 113 0.2 0.201526 GO:0016337 cell-cell adhesion 1 114 0.2 0.203121 GO:0015980 energy derivation by oxidation of organic compounds 1 118 0.2 0.209471 GO:0000278 mitotic cell cycle 1 119 0.2 0.211051 GO:0007243 protein kinase cascade 1 120 0.2 0.212628 GO:0006091 energy pathways 1 123 0.2 0.21734 GO:0042221 response to chemical substance 3 822 1.6 0.221014 GO:0009653 morphogenesis 1 128 0.2 0.225133 GO:0004721 phosphoprotein phosphatase activity 1 131 0.2 0.229773 GO:0004866 endopeptidase inhibitor activity 1 132 0.2 0.231313 GO:0030414 protease inhibitor activity 1 139 0.2 0.242015 GO:0016023 cytoplasmic vesicle 1 141 0.2 0.245046 GO:0008610 lipid biosynthesis 2 500 0.9 0.260764 GO:0005509 calcium ion binding 1 158 0.3 0.270344 GO:0006928 cell motility 1 165 0.3 0.280521 GO:0005624 membrane fraction 3 2374 4.7 0.284068 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 4 1372 2.7 0.286536 GO:0016740 transferase activity 1 1221 2.4 0.290145 u GO:0046914 transition metal ion binding 1 172 0.3 0.290561 GO:0042981 regulation of apoptosis 1 174 0.3 0.293405 GO:0043067 regulation of programmed cell death 1 176 0.3 0.296238 GO:0004857 enzyme inhibitor activity 1 180 0.3 0.30187 GO:0000267 cell fraction 4 1415 2.8 0.306336 GO:0007275 development 1 187 0.3 0.311623 GO:0016757 transferase activity, transferring glycosyl groups 1 187 0.3 0.311623 GO:0016791 phosphoric monoester hydrolase activity 2 582 1.1 0.321639 GO:0016043 cell organization and biogenesis 1 200 0.3 0.329388 GO:0005829 cytosol 2 594 1.1 0.330496 GO:0016788 hydrolase activity, acting on ester bonds 6 2384 4.7 0.330563 GO:0019538 protein metabolism 2 596 1.1 0.33197 GO:0003700 transcription factor activity 1 204 0.4 0.334765 GO:0007264 small GTPase mediated signal transduction 1 204 0.4 0.334765 GO:0009628 response to abiotic stimulus 4 2750 5.4 0.340147 u GO:0008151 cell growth and/or maintenance 10 5831 11.5 0.346433 u GO:0009987 cellular process 4 2728 5.4 0.347758 u GO:0007165 signal transduction 1 1095 2.1 0.349989 u GO:0008270 zinc ion binding 4 2672 5.2 0.367546 u GO:0003676 nucleic acid binding 5 3131 6.2 0.389438 u GO:0050875 cellular physiological process 1 250 0.4 0.393683 GO:0016887 ATPase activity 4 1604 3.1 0.394971 GO:0003677 DNA binding 1 264 0.5 0.410593 GO:0016567 protein ubiquitination 1 268 0.5 0.415341 GO:0000151 ubiquitin ligase complex 6 3552 7 0.421018 u GO:0016021 integral to membrane 2 724 1.4 0.424141 GO:0009059 macromolecule biosynthesis 1 280 0.5 0.429362 GO:0005794 Golgi apparatus 6 2670 5.2 0.440011 GO:0005634 nucleus 7 3170 6.2 0.444196 GO:0007154 cell communication 1 297 0.5 0.448672 GO:0030001 metal ion transport 1 307 0.6 0.459735 GO:0004842 ubiquitin-protein ligase activity 2 776 1.5 0.459931 GO:0030528 transcription regulator activity 1 309 0.6 0.461922 GO:0006915 apoptosis 1 313 0.6 0.46627 GO:0012501 programmed cell death 16 8414 16.6 0.468376 u GO:0007582 physiological process 1 879 1.7 0.472843 u GO:0009605 response to external stimulus 1 326 0.6 0.480168 GO:0016881 acid-D-amino acid ligase activity 3 1874 3.7 0.480555 u GO:0046872 metal ion binding 4 1795 3.5 0.483826 GO:0016787 hydrolase activity 1 343 0.6 0.497817 GO:0008219 cell death 1 345 0.6 0.499855 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 346 0.6 0.500871 GO:0016265 death 1 348 0.6 0.502896 GO:0016817 hydrolase activity, acting on acid anhydrides 1 350 0.6 0.504915 GO:0006629 lipid metabolism 12 5837 11.5 0.505809 GO:0008152 metabolism 1 360 0.7 0.514887 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1 368 0.7 0.522725 GO:0006512 ubiquitin cycle 2 872 1.7 0.522755 GO:0009058 biosynthesis 1 797 1.5 0.52595 u GO:0009056 catabolism 2 884 1.7 0.530286 GO:0050874 organismal physiological process 3 1393 2.7 0.530793 GO:0006355 regulation of transcription, DNA-dependent 1 384 0.7 0.538036 GO:0030234 enzyme regulator activity 3 1417 2.8 0.542839 GO:0006351 transcription, DNA-dependent 1 399 0.7 0.55196 GO:0006812 cation transport 3 1452 2.8 0.560117 GO:0045449 regulation of transcription 3 1458 2.8 0.563044 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 3 1656 3.2 0.58059 u GO:0006810 transport 1 444 0.8 0.591345 GO:0006412 protein biosynthesis 1 456 0.9 0.60127 GO:0004175 endopeptidase activity 3 1606 3.1 0.604087 u GO:0050791 regulation of physiological process 1 460 0.9 0.604526 GO:0016874 ligase activity 4 2048 4 0.616869 u GO:0050789 regulation of biological process 3 1564 3 0.623872 u GO:0019222 regulation of metabolism 1 491 0.9 0.628909 GO:0007049 cell cycle 1 496 0.9 0.632703 GO:0050794 regulation of cellular process 1 634 1.2 0.640183 u GO:0005886 plasma membrane 1 632 1.2 0.64164 u GO:0005739 mitochondrion 3 1516 3 0.646473 u GO:0006350 transcription 1 625 1.2 0.646749 u GO:0005198 structural molecule activity 1 622 1.2 0.648942 u GO:0008233 peptidase activity 2 1058 2 0.649616 u GO:0050896 response to stimulus 1 620 1.2 0.650405 u GO:0006811 ion transport 1 619 1.2 0.651137 u GO:0008283 cell proliferation 1 599 1.1 0.665821 u GO:0016491 oxidoreductase activity 1 517 1 0.726601 u GO:0006950 response to stress