# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 43 #b referenced loci : 41 #c annotated loci : 37 #d hyper-geometric : n 37 hgN 14129 #e k hgK Exp k p-value term description 3 49 0.1 0.000280331 GO:0005789 endoplasmic reticulum membrane 3 50 0.1 0.000297688 GO:0042175 nuclear envelope-endoplasmic reticulum network 14 2064 5.4 0.000427909 GO:0005515 protein binding 8 749 1.9 0.000588488 GO:0016301 kinase activity 4 157 0.4 0.000728369 GO:0012505 endomembrane system 3 74 0.1 0.000942934 GO:0005516 calmodulin binding 28 7041 18.4 0.00118453 GO:0005488 binding 3 102 0.2 0.00237503 GO:0045202 synapse 1 1 0 0.00261873 GO:0005955 calcineurin complex 1 1 0 0.00261873 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00261873 GO:0008089 anterograde axon cargo transport 1 1 0 0.00261873 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00261873 GO:0030325 adrenal gland development 1 2 0 0.00523078 GO:0008250 oligosaccharyl transferase complex 1 2 0 0.00523078 GO:0018196 peptidyl-asparagine modification 1 2 0 0.00523078 GO:0018279 N-linked glycosylation via asparagine 1 2 0 0.00523078 GO:0030517 negative regulation of axon extension 1 3 0 0.00783618 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 5 496 1.2 0.00900851 GO:0004672 protein kinase activity 5 514 1.3 0.0104138 GO:0005856 cytoskeleton 1 4 0 0.0104349 GO:0001515 opioid peptide activity 1 4 0 0.0104349 GO:0007435 salivary gland morphogenesis 1 4 0 0.0104349 GO:0008088 axon cargo transport 1 4 0 0.0104349 GO:0045767 regulation of anti-apoptosis 4 345 0.9 0.012229 GO:0004674 protein serine/threonine kinase activity 1 5 0 0.0130271 GO:0004576 oligosaccharyl transferase activity 1 5 0 0.0130271 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0130271 GO:0030516 regulation of axon extension 1 5 0 0.0130271 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0130271 GO:0030866 cortical actin cytoskeleton organization and biogenesis 2 73 0.1 0.0156043 GO:0005875 microtubule associated complex 1 6 0 0.0156126 GO:0001658 ureteric bud branching 1 6 0 0.0156126 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0156126 GO:0007431 salivary gland development 1 6 0 0.0156126 GO:0019894 kinesin binding 5 586 1.5 0.0175518 GO:0016773 phosphotransferase activity, alcohol group as acceptor 3 222 0.5 0.0200819 GO:0008092 cytoskeletal protein binding 1 8 0 0.0207639 GO:0030659 cytoplasmic vesicle membrane 8 1366 3.5 0.0227497 GO:0017076 purine nucleotide binding 1 9 0 0.0233297 GO:0017124 SH3 domain binding 8 1374 3.5 0.0234789 GO:0000166 nucleotide binding 1 10 0 0.025889 GO:0001763 branching morphogenesis 1 11 0 0.0284417 GO:0001657 ureteric bud development 1 11 0 0.0284417 GO:0042472 inner ear morphogenesis 5 669 1.7 0.0291707 GO:0006793 phosphorus metabolism 5 669 1.7 0.0291707 GO:0006796 phosphate metabolism 1 12 0 0.0309879 GO:0006487 N-linked glycosylation 1 12 0 0.0309879 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0309879 GO:0042471 ear morphogenesis 3 270 0.7 0.0332578 GO:0005578 extracellular matrix 1 13 0 0.0335277 GO:0007548 sex differentiation 1 13 0 0.0335277 GO:0016998 cell wall catabolism 1 13 0 0.0335277 GO:0042493 response to drug 1 14 0 0.0360609 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0360609 GO:0012506 vesicle membrane 12 2707 7 0.03846 GO:0005737 cytoplasm 1 15 0 0.0385877 GO:0004722 protein serine/threonine phosphatase activity 1 15 0 0.0385877 GO:0008207 C21-steroid hormone metabolism 1 15 0 0.0385877 GO:0008286 insulin receptor signaling pathway 2 119 0.3 0.03868 GO:0007243 protein kinase cascade 2 119 0.3 0.03868 GO:0009790 embryonic development 2 122 0.3 0.040466 GO:0007268 synaptic transmission 4 500 1.3 0.040738 GO:0005509 calcium ion binding 1 16 0 0.0411081 GO:0030176 integral to endoplasmic reticulum membrane 4 509 1.3 0.0430417 GO:0006468 protein amino acid phosphorylation 1 17 0 0.043622 GO:0016323 basolateral plasma membrane 2 128 0.3 0.0441302 GO:0019226 transmission of nerve impulse 2 128 0.3 0.0441302 GO:0050905 neuromuscular physiological process 2 131 0.3 0.0460073 GO:0003774 motor activity 1 18 0 0.0461295 GO:0001656 metanephros development 1 18 0 0.0461295 GO:0001822 kidney development 1 18 0 0.0461295 GO:0042446 hormone biosynthesis 1 19 0 0.0486306 GO:0001655 urogenital system development 1 19 0 0.0486306 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0486306 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0486306 GO:0030286 dynein complex 5 771 2 0.0490461 GO:0016772 transferase activity, transferring phosphorus-containing groups 2 138 0.3 0.0505003 GO:0015630 microtubule cytoskeleton 3 321 0.8 0.0511625 GO:0046907 intracellular transport 3 327 0.8 0.0535257 GO:0005783 endoplasmic reticulum 1 21 0 0.0536137 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0 0.0536137 GO:0008287 protein serine/threonine phosphatase complex 1 22 0 0.0560957 GO:0046982 protein heterodimerization activity 6 1067 2.7 0.0568437 GO:0005524 ATP binding 4 559 1.4 0.0571761 GO:0016310 phosphorylation 6 1078 2.8 0.0592087 GO:0030554 adenyl nucleotide binding 2 151 0.3 0.059244 GO:0007267 cell-cell signaling 1 24 0 0.0610408 GO:0003777 microtubule motor activity 1 24 0 0.0610408 GO:0006112 energy reserve metabolism 1 24 0 0.0610408 GO:0019933 cAMP-mediated signaling 1 25 0 0.0635039 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0635039 GO:0008017 microtubule binding 2 160 0.4 0.0655832 GO:0003779 actin binding 2 162 0.4 0.0670221 GO:0004713 protein-tyrosine kinase activity 1 1597 4.1 0.0673084 u GO:0007186 G-protein coupled receptor protein signaling pathway 1 27 0 0.0684111 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.0684111 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 2 165 0.4 0.0692002 GO:0005624 membrane fraction 1 28 0 0.0708554 GO:0019935 cyclic-nucleotide-mediated signaling 1 30 0 0.0757252 GO:0015631 tubulin binding 6 1161 3 0.0789917 GO:0006464 protein modification 2 180 0.4 0.0804333 GO:0000267 cell fraction 1 32 0 0.0805701 GO:0018193 peptidyl-amino acid modification 1 32 0 0.0805701 GO:0019904 protein domain specific binding 2 183 0.4 0.0827451 GO:0050879 organismal movement 19 5553 14.5 0.0921851 GO:0005622 intracellular 4 660 1.7 0.0925031 GO:0007242 intracellular signaling cascade 1 37 0 0.0925747 GO:0007411 axon guidance 1 37 0 0.0925747 GO:0019932 second-messenger-mediated signaling 1 38 0 0.0949572 GO:0007018 microtubule-based movement 1 38 0 0.0949572 GO:0030705 cytoskeleton-dependent intracellular transport 2 200 0.5 0.0962228 GO:0005829 cytosol 1 39 0.1 0.0973336 GO:0042445 hormone metabolism 2 204 0.5 0.099482 GO:0007010 cytoskeleton organization and biogenesis 1 40 0.1 0.099704 GO:0000165 MAPKKK cascade 1 41 0.1 0.102068 GO:0006694 steroid biosynthesis 2 1922 5 0.104031 u GO:0007166 cell surface receptor linked signal transduction 1 44 0.1 0.109125 GO:0007420 brain development 2 218 0.5 0.11113 GO:0006886 intracellular protein transport 3 2359 6.1 0.113085 u GO:0004872 receptor activity 1 46 0.1 0.1138 GO:0006606 protein-nucleus import 1 46 0.1 0.1138 GO:0009795 embryonic morphogenesis 1 47 0.1 0.116128 GO:0045211 postsynaptic membrane 1 51 0.1 0.125382 GO:0005941 unlocalized 4 2750 7.2 0.127272 u GO:0008151 cell growth and/or maintenance 2 243 0.6 0.132761 GO:0042578 phosphoric ester hydrolase activity 2 244 0.6 0.133646 GO:0006996 organelle organization and biogenesis 1 56 0.1 0.136817 GO:0016563 transcriptional activator activity 5 3131 8.1 0.140519 u GO:0050875 cellular physiological process 1 58 0.1 0.14135 GO:0005730 nucleolus 1 58 0.1 0.14135 GO:0006916 anti-apoptosis 6 3552 9.3 0.142483 u GO:0016021 integral to membrane 1 59 0.1 0.143607 GO:0005635 nuclear membrane 1 59 0.1 0.143607 GO:0008081 phosphoric diester hydrolase activity 6 1372 3.5 0.144458 GO:0016740 transferase activity 1 60 0.1 0.14586 GO:0046983 protein dimerization activity 2 259 0.6 0.147083 GO:0007399 neurogenesis 1 62 0.1 0.150346 GO:0007417 central nervous system development 1 63 0.1 0.152581 GO:0006486 protein amino acid glycosylation 1 63 0.1 0.152581 GO:0007409 axonogenesis 1 63 0.1 0.152581 GO:0030036 actin cytoskeleton organization and biogenesis 1 66 0.1 0.159251 GO:0043066 negative regulation of apoptosis 1 66 0.1 0.159251 GO:0043069 negative regulation of programmed cell death 1 67 0.1 0.161463 GO:0030029 actin filament-based process 1 69 0.1 0.16587 GO:0009101 glycoprotein biosynthesis 1 70 0.1 0.168066 GO:0006816 calcium ion transport 2 286 0.7 0.171931 GO:0005525 GTP binding 2 286 0.7 0.171931 GO:0007028 cytoplasm organization and biogenesis 15 4537 11.8 0.177062 GO:0003824 catalytic activity 12 5831 15.2 0.177644 u GO:0009987 cellular process 1 75 0.1 0.178957 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 2 294 0.7 0.179431 GO:0019001 guanyl nucleotide binding 1 77 0.2 0.183274 GO:0009100 glycoprotein metabolism 5 2958 7.7 0.183413 u GO:0004871 signal transducer activity 1 82 0.2 0.193972 GO:0008202 steroid metabolism 1 83 0.2 0.196095 GO:0007156 homophilic cell adhesion 1 84 0.2 0.198213 GO:0007017 microtubule-based process 1 85 0.2 0.200325 GO:0006913 nucleocytoplasmic transport 2 319 0.8 0.203182 GO:0050877 neurophysiological process 7 1874 4.9 0.212405 GO:0046872 metal ion binding 1 91 0.2 0.212885 GO:0004867 serine-type endopeptidase inhibitor activity 1 92 0.2 0.21496 GO:0005083 small GTPase regulatory/interacting protein activity 1 93 0.2 0.217029 GO:0006605 protein targeting 6 1604 4.2 0.238402 GO:0003677 DNA binding 2 358 0.9 0.240905 GO:0015031 protein transport 1 106 0.2 0.243451 GO:0016477 cell migration 1 110 0.2 0.251405 GO:0015674 di-, tri-valent inorganic cation transport 1 110 0.2 0.251405 GO:0016758 transferase activity, transferring hexosyl groups 9 2670 6.9 0.254687 GO:0005634 nucleus 1 112 0.2 0.255352 GO:0006357 regulation of transcription from Pol II promoter 1 112 0.2 0.255352 GO:0016311 dephosphorylation 1 113 0.2 0.257317 GO:0016337 cell-cell adhesion 1 114 0.2 0.259278 GO:0015980 energy derivation by oxidation of organic compounds 2 384 1 0.266293 GO:0030234 enzyme regulator activity 1 118 0.3 0.26707 GO:0000278 mitotic cell cycle 1 118 0.3 0.26707 GO:0007167 enzyme linked receptor protein signaling pathway 1 120 0.3 0.270936 GO:0006091 energy pathways 2 390 1 0.272161 GO:0007155 cell adhesion 3 698 1.8 0.275524 GO:0009887 organogenesis 1 123 0.3 0.276698 GO:0042221 response to chemical substance 1 128 0.3 0.286203 GO:0004721 phosphoprotein phosphatase activity 1 131 0.3 0.291847 GO:0004866 endopeptidase inhibitor activity 3 723 1.8 0.293593 GO:0005576 extracellular 1 132 0.3 0.293719 GO:0030414 protease inhibitor activity 5 1393 3.6 0.298829 GO:0006355 regulation of transcription, DNA-dependent 20 8414 22 0.300996 u GO:0007582 physiological process 1 139 0.3 0.306688 GO:0016023 cytoplasmic vesicle 1 139 0.3 0.306688 GO:0030695 GTPase regulator activity 1 141 0.3 0.31035 GO:0008610 lipid biosynthesis 5 1415 3.7 0.310461 GO:0007275 development 5 1417 3.7 0.311523 GO:0006351 transcription, DNA-dependent 1 146 0.3 0.319424 GO:0006366 transcription from Pol II promoter 1 879 2.3 0.320433 u GO:0009605 response to external stimulus 5 1452 3.8 0.330199 GO:0045449 regulation of transcription 3 776 2 0.33219 GO:0030528 transcription regulator activity 5 1458 3.8 0.333417 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 158 0.4 0.340731 GO:0006928 cell motility 3 1656 4.3 0.355429 u GO:0006810 transport 5 1516 3.9 0.364709 GO:0006350 transcription 1 172 0.4 0.364769 GO:0042981 regulation of apoptosis 3 822 2.1 0.365758 GO:0009653 morphogenesis 1 174 0.4 0.368133 GO:0043067 regulation of programmed cell death 1 176 0.4 0.371479 GO:0004857 enzyme inhibitor activity 1 797 2 0.374411 u GO:0009056 catabolism 1 187 0.4 0.389578 GO:0016757 transferase activity, transferring glycosyl groups 1 187 0.4 0.389578 GO:0016791 phosphoric monoester hydrolase activity 5 1564 4 0.390756 GO:0019222 regulation of metabolism 5 2374 6.2 0.393777 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 2 517 1.3 0.394586 GO:0006950 response to stress 6 2728 7.1 0.410128 u GO:0007165 signal transduction 5 1606 4.2 0.413562 GO:0050791 regulation of physiological process 1 204 0.5 0.416556 GO:0007264 small GTPase mediated signal transduction 1 204 0.5 0.416556 GO:0009628 response to abiotic stimulus 7 2384 6.2 0.436012 GO:0019538 protein metabolism 6 2048 5.3 0.452332 GO:0050789 regulation of biological process 2 582 1.5 0.454078 GO:0016043 cell organization and biogenesis 9 3170 8.3 0.454399 GO:0007154 cell communication 2 594 1.5 0.464723 GO:0016788 hydrolase activity, acting on ester bonds 2 596 1.5 0.466487 GO:0003700 transcription factor activity 16 5837 15.2 0.467628 GO:0008152 metabolism 1 250 0.6 0.483868 GO:0016887 ATPase activity 4 1795 4.7 0.485527 u GO:0016787 hydrolase activity 1 634 1.6 0.500639 u GO:0005886 plasma membrane 1 632 1.6 0.502338 u GO:0005739 mitochondrion 1 264 0.6 0.50281 GO:0016567 protein ubiquitination 1 268 0.7 0.508097 GO:0000151 ubiquitin ligase complex 1 625 1.6 0.508315 u GO:0005198 structural molecule activity 1 622 1.6 0.510889 u GO:0008233 peptidase activity 1 620 1.6 0.51261 u GO:0006811 ion transport 1 619 1.6 0.513471 u GO:0008283 cell proliferation 1 280 0.7 0.52363 GO:0005794 Golgi apparatus 1 599 1.5 0.530875 u GO:0016491 oxidoreductase activity 3 1058 2.7 0.53096 GO:0050896 response to stimulus 1 297 0.7 0.544822 GO:0030001 metal ion transport 12 4555 11.9 0.551667 GO:0016020 membrane 3 1095 2.8 0.554928 GO:0008270 zinc ion binding 1 307 0.8 0.556856 GO:0004842 ubiquitin-protein ligase activity 24 9173 24 0.558738 u GO:0005623 cell 1 309 0.8 0.559226 GO:0006915 apoptosis 1 313 0.8 0.563928 GO:0012501 programmed cell death 7 2672 6.9 0.565847 GO:0003676 nucleic acid binding 2 724 1.8 0.572137 GO:0009059 macromolecule biosynthesis 1 326 0.8 0.578874 GO:0016881 acid-D-amino acid ligase activity 2 884 2.3 0.589333 u GO:0050874 organismal physiological process 1 337 0.8 0.591131 GO:0006118 electron transport 1 343 0.8 0.597669 GO:0008219 cell death 2 872 2.2 0.597974 u GO:0009058 biosynthesis 1 345 0.9 0.599826 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 346 0.9 0.6009 GO:0016265 death 3 1221 3.1 0.601161 u GO:0046914 transition metal ion binding 1 348 0.9 0.60304 GO:0016817 hydrolase activity, acting on acid anhydrides 1 350 0.9 0.605169 GO:0006629 lipid metabolism 1 360 0.9 0.615647 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1 368 0.9 0.623835 GO:0006512 ubiquitin cycle 1 496 1.2 0.625214 u GO:0050794 regulation of cellular process 1 491 1.2 0.629963 u GO:0007049 cell cycle 1 460 1.2 0.659672 u GO:0016874 ligase activity 1 456 1.1 0.663535 u GO:0004175 endopeptidase activity 1 444 1.1 0.675155 u GO:0006412 protein biosynthesis 1 433 1.1 0.685844 u GO:0005102 receptor binding 1 399 1 0.719035 u GO:0006812 cation transport