# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 50 #b referenced loci : 48 #c annotated loci : 42 #d hyper-geometric : n 42 hgN 14129 #e k hgK Exp k p-value term description 16 2064 6.1 0.000154068 GO:0005515 protein binding 3 49 0.1 0.000409169 GO:0005789 endoplasmic reticulum membrane 3 50 0.1 0.000434389 GO:0042175 nuclear envelope-endoplasmic reticulum network 4 157 0.4 0.00118242 GO:0012505 endomembrane system 31 7041 20.9 0.00132728 GO:0005488 binding 3 74 0.2 0.00136729 GO:0005516 calmodulin binding 8 749 2.2 0.00142363 GO:0016301 kinase activity 1 1 0 0.00297261 GO:0005955 calcineurin complex 1 1 0 0.00297261 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00297261 GO:0008089 anterograde axon cargo transport 1 1 0 0.00297261 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00297261 GO:0030325 adrenal gland development 3 102 0.3 0.00341879 GO:0045202 synapse 6 514 1.5 0.00387879 GO:0005856 cytoskeleton 1 2 0 0.00593659 GO:0008250 oligosaccharyl transferase complex 1 2 0 0.00593659 GO:0018196 peptidyl-asparagine modification 1 2 0 0.00593659 GO:0018279 N-linked glycosylation via asparagine 1 2 0 0.00593659 GO:0030517 negative regulation of axon extension 1 3 0 0.00889197 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 1 3 0 0.00889197 GO:0004828 serine-tRNA ligase activity 1 3 0 0.00889197 GO:0006434 seryl-tRNA aminoacylation 1 4 0 0.0118388 GO:0001515 opioid peptide activity 1 4 0 0.0118388 GO:0007435 salivary gland morphogenesis 1 4 0 0.0118388 GO:0008088 axon cargo transport 1 4 0 0.0118388 GO:0045767 regulation of anti-apoptosis 1 5 0 0.014777 GO:0000145 exocyst 1 5 0 0.014777 GO:0004576 oligosaccharyl transferase activity 1 5 0 0.014777 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.014777 GO:0030516 regulation of axon extension 1 5 0 0.014777 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.014777 GO:0030866 cortical actin cytoskeleton organization and biogenesis 5 496 1.4 0.0152455 GO:0004672 protein kinase activity 4 327 0.9 0.0157939 GO:0005783 endoplasmic reticulum 9 1366 4 0.0171077 GO:0017076 purine nucleotide binding 1 6 0 0.0177067 GO:0001658 ureteric bud branching 1 6 0 0.0177067 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0177067 GO:0007431 salivary gland development 1 6 0 0.0177067 GO:0019894 kinesin binding 9 1374 4 0.0177178 GO:0000166 nucleotide binding 4 345 1 0.0188532 GO:0004674 protein serine/threonine kinase activity 2 73 0.2 0.0198421 GO:0005875 microtubule associated complex 14 2707 8 0.020916 GO:0005737 cytoplasm 1 8 0 0.0235407 GO:0030659 cytoplasmic vesicle membrane 1 9 0 0.026445 GO:0017124 SH3 domain binding 3 222 0.6 0.0280307 GO:0008092 cytoskeletal protein binding 5 586 1.7 0.0289597 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 10 0 0.0293408 GO:0001763 branching morphogenesis 1 11 0 0.0322282 GO:0001657 ureteric bud development 1 11 0 0.0322282 GO:0042472 inner ear morphogenesis 1 12 0 0.0351073 GO:0006487 N-linked glycosylation 1 12 0 0.0351073 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0351073 GO:0042471 ear morphogenesis 7 1067 3.1 0.0362224 GO:0005524 ATP binding 1 13 0 0.037978 GO:0005938 cell cortex 1 13 0 0.037978 GO:0007548 sex differentiation 1 13 0 0.037978 GO:0016998 cell wall catabolism 1 13 0 0.037978 GO:0042493 response to drug 7 1078 3.2 0.0379923 GO:0030554 adenyl nucleotide binding 1 14 0 0.0408403 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0408403 GO:0012506 vesicle membrane 1 1597 4.7 0.041013 u GO:0007186 G-protein coupled receptor protein signaling pathway 1 15 0 0.0436944 GO:0004722 protein serine/threonine phosphatase activity 1 15 0 0.0436944 GO:0008207 C21-steroid hormone metabolism 1 15 0 0.0436944 GO:0008286 insulin receptor signaling pathway 3 270 0.8 0.045866 GO:0005578 extracellular matrix 1 16 0 0.0465401 GO:0030176 integral to endoplasmic reticulum membrane 5 669 1.9 0.0470308 GO:0006793 phosphorus metabolism 5 669 1.9 0.0470308 GO:0006796 phosphate metabolism 2 119 0.3 0.0486728 GO:0007243 protein kinase cascade 2 119 0.3 0.0486728 GO:0009790 embryonic development 1 17 0 0.0493776 GO:0016323 basolateral plasma membrane 2 122 0.3 0.0508858 GO:0007268 synaptic transmission 1 18 0 0.0522068 GO:0001656 metanephros development 1 18 0 0.0522068 GO:0001822 kidney development 1 18 0 0.0522068 GO:0042446 hormone biosynthesis 1 19 0 0.0550278 GO:0001655 urogenital system development 1 19 0 0.0550278 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0550278 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0550278 GO:0030286 dynein complex 2 128 0.3 0.0554189 GO:0019226 transmission of nerve impulse 2 128 0.3 0.0554189 GO:0050905 neuromuscular physiological process 2 131 0.3 0.0577374 GO:0003774 motor activity 22 5553 16.5 0.058423 GO:0005622 intracellular 4 500 1.4 0.0602626 GO:0005509 calcium ion binding 1 21 0 0.0606453 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0 0.0606453 GO:0008287 protein serine/threonine phosphatase complex 2 1922 5.7 0.0620554 u GO:0007166 cell surface receptor linked signal transduction 3 2359 7 0.0632361 u GO:0004872 receptor activity 2 138 0.4 0.0632768 GO:0015630 microtubule cytoskeleton 1 22 0 0.0634418 GO:0046982 protein heterodimerization activity 4 509 1.5 0.0635202 GO:0006468 protein amino acid phosphorylation 1 24 0 0.0690104 GO:0003777 microtubule motor activity 1 24 0 0.0690104 GO:0006112 energy reserve metabolism 1 24 0 0.0690104 GO:0019933 cAMP-mediated signaling 3 321 0.9 0.0696735 GO:0046907 intracellular transport 1 25 0 0.0717826 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0717826 GO:0008017 microtubule binding 2 151 0.4 0.0740182 GO:0007267 cell-cell signaling 5 771 2.2 0.0768914 GO:0016772 transferase activity, transferring phosphorus-containing groups 1 27 0 0.0773028 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.0773028 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 1 28 0 0.0800509 GO:0019935 cyclic-nucleotide-mediated signaling 2 160 0.4 0.0817753 GO:0003779 actin binding 4 559 1.6 0.0832874 GO:0016310 phosphorylation 2 162 0.4 0.0835325 GO:0004713 protein-tyrosine kinase activity 1 30 0 0.085523 GO:0015631 tubulin binding 2 165 0.4 0.0861902 GO:0005624 membrane fraction 3 358 1 0.0898297 GO:0015031 protein transport 1 32 0 0.0909635 GO:0018193 peptidyl-amino acid modification 1 32 0 0.0909635 GO:0019904 protein domain specific binding 1 34 0.1 0.0963723 GO:0006887 exocytosis 2 180 0.5 0.0998519 GO:0000267 cell fraction 5 2958 8.7 0.100518 u GO:0004871 signal transducer activity 2 183 0.5 0.102654 GO:0050879 organismal movement 1 37 0.1 0.104427 GO:0007411 axon guidance 1 37 0.1 0.104427 GO:0019932 second-messenger-mediated signaling 1 38 0.1 0.107096 GO:0007018 microtubule-based movement 1 38 0.1 0.107096 GO:0030705 cytoskeleton-dependent intracellular transport 3 390 1.1 0.109026 GO:0007155 cell adhesion 1 39 0.1 0.109757 GO:0006418 tRNA aminoacylation for protein translation 1 39 0.1 0.109757 GO:0042445 hormone metabolism 1 39 0.1 0.109757 GO:0043038 amino acid activation 1 39 0.1 0.109757 GO:0043039 tRNA aminoacylation 1 40 0.1 0.112411 GO:0000165 MAPKKK cascade 1 41 0.1 0.115057 GO:0004812 tRNA ligase activity 1 41 0.1 0.115057 GO:0006694 steroid biosynthesis 1 41 0.1 0.115057 GO:0008452 RNA ligase activity 1 41 0.1 0.115057 GO:0016875 ligase activity, forming carbon-oxygen bonds 1 41 0.1 0.115057 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 1 42 0.1 0.117695 GO:0006400 tRNA modification 2 200 0.5 0.118935 GO:0005829 cytosol 2 204 0.6 0.122856 GO:0007010 cytoskeleton organization and biogenesis 1 44 0.1 0.122949 GO:0007420 brain development 6 1161 3.4 0.126908 GO:0006464 protein modification 1 46 0.1 0.128172 GO:0006606 protein-nucleus import 1 46 0.1 0.128172 GO:0009795 embryonic morphogenesis 1 47 0.1 0.130772 GO:0016886 ligase activity, forming phosphoric ester bonds 1 47 0.1 0.130772 GO:0045211 postsynaptic membrane 4 660 1.9 0.131309 GO:0007242 intracellular signaling cascade 1 49 0.1 0.135949 GO:0009451 RNA modification 7 3552 10.5 0.136269 u GO:0016021 integral to membrane 2 218 0.6 0.136828 GO:0006886 intracellular protein transport 1 51 0.1 0.141096 GO:0005941 unlocalized 5 2750 8.1 0.146792 u GO:0008151 cell growth and/or maintenance 6 3131 9.3 0.146916 u GO:0050875 cellular physiological process 1 56 0.1 0.153834 GO:0016563 transcriptional activator activity 1 58 0.1 0.158877 GO:0005730 nucleolus 1 58 0.1 0.158877 GO:0006916 anti-apoptosis 1 59 0.1 0.161388 GO:0005635 nuclear membrane 1 59 0.1 0.161388 GO:0008081 phosphoric diester hydrolase activity 2 243 0.7 0.162592 GO:0042578 phosphoric ester hydrolase activity 2 244 0.7 0.163641 GO:0006996 organelle organization and biogenesis 1 60 0.1 0.163891 GO:0046983 protein dimerization activity 1 62 0.1 0.168876 GO:0007417 central nervous system development 1 63 0.1 0.171358 GO:0006486 protein amino acid glycosylation 1 63 0.1 0.171358 GO:0007409 axonogenesis 1 63 0.1 0.171358 GO:0030036 actin cytoskeleton organization and biogenesis 1 65 0.1 0.176299 GO:0006399 tRNA metabolism 1 66 0.1 0.178759 GO:0043066 negative regulation of apoptosis 1 66 0.1 0.178759 GO:0043069 negative regulation of programmed cell death 2 259 0.7 0.179525 GO:0007399 neurogenesis 1 67 0.1 0.181212 GO:0030029 actin filament-based process 1 69 0.2 0.186095 GO:0009101 glycoprotein biosynthesis 1 69 0.2 0.186095 GO:0045045 secretory pathway 14 5831 17.3 0.18754 u GO:0009987 cellular process 1 70 0.2 0.188527 GO:0006816 calcium ion transport 1 75 0.2 0.200577 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 1 77 0.2 0.205348 GO:0009100 glycoprotein metabolism 2 286 0.8 0.208675 GO:0005525 GTP binding 2 286 0.8 0.208675 GO:0007028 cytoplasm organization and biogenesis 22 8414 25 0.213589 u GO:0007582 physiological process 1 82 0.2 0.217155 GO:0008202 steroid metabolism 2 294 0.8 0.217418 GO:0019001 guanyl nucleotide binding 6 1372 4 0.219162 GO:0016740 transferase activity 1 83 0.2 0.219496 GO:0007156 homophilic cell adhesion 1 84 0.2 0.221829 GO:0007017 microtubule-based process 1 85 0.2 0.224157 GO:0006913 nucleocytoplasmic transport 1 91 0.2 0.237977 GO:0004867 serine-type endopeptidase inhibitor activity 1 92 0.2 0.240257 GO:0005083 small GTPase regulatory/interacting protein activity 1 93 0.2 0.24253 GO:0006605 protein targeting 2 319 0.9 0.24494 GO:0050877 neurophysiological process 16 4537 13.4 0.249292 GO:0003824 catalytic activity 1 879 2.6 0.254583 u GO:0009605 response to external stimulus 10 2670 7.9 0.26045 GO:0005634 nucleus 1 106 0.3 0.271484 GO:0016477 cell migration 6 2728 8.1 0.272812 u GO:0007165 signal transduction 1 110 0.3 0.280174 GO:0015674 di-, tri-valent inorganic cation transport 1 110 0.3 0.280174 GO:0016758 transferase activity, transferring hexosyl groups 1 112 0.3 0.284481 GO:0006357 regulation of transcription from Pol II promoter 1 112 0.3 0.284481 GO:0016311 dephosphorylation 1 113 0.3 0.286625 GO:0016337 cell-cell adhesion 1 114 0.3 0.288762 GO:0015980 energy derivation by oxidation of organic compounds 1 118 0.3 0.297251 GO:0000278 mitotic cell cycle 1 118 0.3 0.297251 GO:0007167 enzyme linked receptor protein signaling pathway 1 120 0.3 0.301458 GO:0006091 energy pathways 1 797 2.3 0.305986 u GO:0009056 catabolism 1 123 0.3 0.307722 GO:0042221 response to chemical substance 1 127 0.3 0.31599 GO:0043037 translation 2 384 1.1 0.316885 GO:0030234 enzyme regulator activity 1 128 0.3 0.318041 GO:0004721 phosphoprotein phosphatase activity 7 1874 5.5 0.31967 GO:0046872 metal ion binding 1 131 0.3 0.324161 GO:0004866 endopeptidase inhibitor activity 1 132 0.3 0.326188 GO:0006520 amino acid metabolism 1 132 0.3 0.326188 GO:0030414 protease inhibitor activity 1 139 0.4 0.340218 GO:0016023 cytoplasmic vesicle 1 139 0.4 0.340218 GO:0030695 GTPase regulator activity 6 1604 4.7 0.340586 GO:0003677 DNA binding 3 698 2 0.344056 GO:0009887 organogenesis 1 141 0.4 0.344173 GO:0008610 lipid biosynthesis 1 146 0.4 0.353962 GO:0006366 transcription from Pol II promoter 3 723 2.1 0.364686 GO:0005576 extracellular 3 724 2.1 0.36551 GO:0009059 macromolecule biosynthesis 4 1795 5.3 0.368485 u GO:0016787 hydrolase activity 1 158 0.4 0.376875 GO:0006928 cell motility 2 444 1.3 0.382133 GO:0006412 protein biosynthesis 1 167 0.4 0.393538 GO:0006519 amino acid and derivative metabolism 2 460 1.3 0.399147 GO:0016874 ligase activity 5 1393 4.1 0.399963 GO:0006355 regulation of transcription, DNA-dependent 1 172 0.5 0.402606 GO:0042981 regulation of apoptosis 1 174 0.5 0.406196 GO:0043067 regulation of programmed cell death 3 776 2.3 0.408116 GO:0030528 transcription regulator activity 1 176 0.5 0.409765 GO:0004857 enzyme inhibitor activity 5 1415 4.2 0.413418 GO:0007275 development 5 1417 4.2 0.41464 GO:0006351 transcription, DNA-dependent 8 2384 7 0.415014 GO:0019538 protein metabolism 1 181 0.5 0.418597 GO:0009308 amine metabolism 6 2374 7 0.426496 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 187 0.5 0.429024 GO:0016757 transferase activity, transferring glycosyl groups 1 187 0.5 0.429024 GO:0016791 phosphoric monoester hydrolase activity 1 634 1.8 0.43195 u GO:0005886 plasma membrane 1 632 1.8 0.433697 u GO:0005739 mitochondrion 5 1452 4.3 0.435984 GO:0045449 regulation of transcription 5 1458 4.3 0.439633 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 622 1.8 0.442506 u GO:0008233 peptidase activity 4 1656 4.9 0.443638 u GO:0006810 transport 1 620 1.8 0.444283 u GO:0006811 ion transport 1 619 1.8 0.445173 u GO:0008283 cell proliferation 3 822 2.4 0.445192 GO:0009653 morphogenesis 7 2672 7.9 0.446722 u GO:0003676 nucleic acid binding 1 204 0.6 0.457587 GO:0007264 small GTPase mediated signal transduction 1 204 0.6 0.457587 GO:0009628 response to abiotic stimulus 2 517 1.5 0.457983 GO:0006950 response to stress 1 599 1.7 0.463222 u GO:0016491 oxidoreductase activity 1 212 0.6 0.470541 GO:0016192 vesicle-mediated transport 5 1516 4.5 0.474659 GO:0006350 transcription 10 3170 9.4 0.475007 GO:0007154 cell communication 3 872 2.5 0.484533 GO:0009058 biosynthesis 13 4555 13.5 0.502562 u GO:0016020 membrane 3 1221 3.6 0.502762 u GO:0046914 transition metal ion binding 5 1564 4.6 0.503207 GO:0019222 regulation of metabolism 2 884 2.6 0.506203 u GO:0050874 organismal physiological process 1 238 0.7 0.51059 GO:0016070 RNA metabolism 2 582 1.7 0.521064 GO:0016043 cell organization and biogenesis 17 5837 17.3 0.522225 u GO:0008152 metabolism 27 9173 27.2 0.523495 u GO:0005623 cell 5 1606 4.7 0.527758 GO:0050791 regulation of physiological process 1 250 0.7 0.528061 GO:0016887 ATPase activity 2 594 1.7 0.532191 GO:0016788 hydrolase activity, acting on ester bonds 2 596 1.7 0.534029 GO:0003700 transcription factor activity 1 262 0.7 0.544923 GO:0019752 carboxylic acid metabolism 1 264 0.7 0.547676 GO:0016567 protein ubiquitination 1 265 0.7 0.549046 GO:0006082 organic acid metabolism 1 268 0.7 0.553132 GO:0000151 ubiquitin ligase complex 2 625 1.8 0.560149 GO:0005198 structural molecule activity 1 496 1.4 0.563344 u GO:0050794 regulation of cellular process 1 491 1.4 0.568484 u GO:0007049 cell cycle 1 280 0.8 0.569119 GO:0005794 Golgi apparatus 3 1095 3.2 0.588021 u GO:0008270 zinc ion binding 1 297 0.8 0.590815 GO:0030001 metal ion transport 6 2048 6 0.591375 u GO:0050789 regulation of biological process 1 307 0.9 0.603075 GO:0004842 ubiquitin-protein ligase activity 1 456 1.3 0.605088 u GO:0004175 endopeptidase activity 1 309 0.9 0.605484 GO:0006915 apoptosis 1 313 0.9 0.610258 GO:0012501 programmed cell death 3 1058 3.1 0.613577 u GO:0050896 response to stimulus 1 326 0.9 0.625389 GO:0016881 acid-D-amino acid ligase activity 1 433 1.2 0.629672 u GO:0005102 receptor binding 1 399 1.1 0.66663 u GO:0006812 cation transport 1 368 1 0.700781 u GO:0006512 ubiquitin cycle 1 360 1 0.709637 u GO:0016879 ligase activity, forming carbon-nitrogen bonds 1 350 1 0.720718 u GO:0006629 lipid metabolism 1 348 1 0.722935 u GO:0016817 hydrolase activity, acting on acid anhydrides 1 346 1 0.725153 u GO:0016265 death 1 345 1 0.726261 u GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 343 1 0.728479 u GO:0008219 cell death 1 337 1 0.73513 u GO:0006118 electron transport