# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 153 #b referenced loci : 144 #c annotated loci : 120 #d hyper-geometric : n 120 hgN 14129 #e k hgK Exp k p-value term description 9 3552 30.1 5.51752e-07 u GO:0016021 integral to membrane 8 2958 25.1 1.46588e-05 u GO:0004871 signal transducer activity 5 2359 20 2.20614e-05 u GO:0004872 receptor activity 81 7041 59.8 6.40007e-05 GO:0005488 binding 2 1597 13.5 7.07593e-05 u GO:0007186 G-protein coupled receptor protein signaling pathway 68 5553 47.1 8.32475e-05 GO:0005622 intracellular 4 1922 16.3 0.000145127 u GO:0007166 cell surface receptor linked signal transduction 33 2064 17.5 0.000173511 GO:0005515 protein binding 5 73 0.6 0.000385106 GO:0005875 microtubule associated complex 5 74 0.6 0.000410238 GO:0005516 calmodulin binding 13 514 4.3 0.000420568 GO:0005856 cytoskeleton 12 460 3.9 0.000537316 GO:0016874 ligase activity 3 21 0.1 0.000710655 GO:0043087 regulation of GTPase activity 21 1161 9.8 0.000724028 GO:0006464 protein modification 67 5837 49.5 0.000892854 GO:0008152 metabolism 2 6 0 0.00104939 GO:0019894 kinesin binding 55 4537 38.5 0.00111472 GO:0003824 catalytic activity 6 138 1.1 0.00114361 GO:0015630 microtubule cytoskeleton 10 368 3.1 0.0011632 GO:0006512 ubiquitin cycle 37 2707 22.9 0.00142312 GO:0005737 cytoplasm 19 1067 9 0.00160035 GO:0005524 ATP binding 19 1078 9.1 0.00180107 GO:0030554 adenyl nucleotide binding 24 4555 38.6 0.00196538 u GO:0016020 membrane 33 2384 20.2 0.00229886 GO:0019538 protein metabolism 22 1366 11.6 0.00241441 GO:0017076 purine nucleotide binding 22 1374 11.6 0.0025962 GO:0000166 nucleotide binding 14 749 6.3 0.00446779 GO:0016301 kinase activity 8 307 2.6 0.00465749 GO:0004842 ubiquitin-protein ligase activity 8 326 2.7 0.0066314 GO:0016881 acid-D-amino acid ligase activity 2 15 0.1 0.0069875 GO:0004722 protein serine/threonine phosphatase activity 2 15 0.1 0.0069875 GO:0008286 insulin receptor signaling pathway 14 797 6.7 0.00762514 GO:0009056 catabolism 3 49 0.4 0.00828526 GO:0005789 endoplasmic reticulum membrane 1 1 0 0.00849317 GO:0004438 phosphatidylinositol-3-phosphatase activity 1 1 0 0.00849317 GO:0004691 cAMP-dependent protein kinase activity 1 1 0 0.00849317 GO:0005955 calcineurin complex 1 1 0 0.00849317 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00849317 GO:0008089 anterograde axon cargo transport 1 1 0 0.00849317 GO:0016034 maleylacetoacetate isomerase activity 1 1 0 0.00849317 GO:0016939 kinesin II complex 1 1 0 0.00849317 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00849317 GO:0030325 adrenal gland development 1 1 0 0.00849317 GO:0045023 G0 to G1 transition 1 1 0 0.00849317 GO:0046208 spermine catabolism 1 1 0 0.00849317 GO:0047372 acylglycerol lipase activity 3 50 0.4 0.0087603 GO:0042175 nuclear envelope-endoplasmic reticulum network 3 50 0.4 0.0087603 GO:0050790 regulation of enzyme activity 8 345 2.9 0.00918462 GO:0004674 protein serine/threonine kinase activity 5 157 1.3 0.0108922 GO:0012505 endomembrane system 11 586 4.9 0.0111285 GO:0016773 phosphotransferase activity, alcohol group as acceptor 37 5831 49.5 0.0116678 u GO:0009987 cellular process 8 360 3 0.0116716 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2 21 0.1 0.0135191 GO:0006099 tricarboxylic acid cycle 2 21 0.1 0.0135191 GO:0008287 protein serine/threonine phosphatase complex 5 167 1.4 0.0139338 GO:0006519 amino acid and derivative metabolism 3 62 0.5 0.0157093 GO:0004840 ubiquitin conjugating enzyme activity 3 62 0.5 0.0157093 GO:0008639 small protein conjugating enzyme activity 4 114 0.9 0.0161428 GO:0015980 energy derivation by oxidation of organic compounds 1 2 0 0.0169148 GO:0000209 protein polyubiquitination 1 2 0 0.0169148 GO:0001672 regulation of chromatin assembly/disassembly 1 2 0 0.0169148 GO:0004020 adenylyl-sulfate kinase activity 1 2 0 0.0169148 GO:0004776 succinate-CoA ligase (GDP-forming) activity 1 2 0 0.0169148 GO:0004779 sulfate adenylyltransferase activity 1 2 0 0.0169148 GO:0004781 sulfate adenylyltransferase (ATP) activity 1 2 0 0.0169148 GO:0004827 proline-tRNA ligase activity 1 2 0 0.0169148 GO:0006433 prolyl-tRNA aminoacylation 1 2 0 0.0169148 GO:0006598 polyamine catabolism 1 2 0 0.0169148 GO:0008250 oligosaccharyl transferase complex 1 2 0 0.0169148 GO:0018196 peptidyl-asparagine modification 1 2 0 0.0169148 GO:0018279 N-linked glycosylation via asparagine 1 2 0 0.0169148 GO:0030517 negative regulation of axon extension 1 2 0 0.0169148 GO:0042177 negative regulation of protein catabolism 1 2 0 0.0169148 GO:0045646 regulation of erythrocyte differentiation 1 2 0 0.0169148 GO:0045648 positive regulation of erythrocyte differentiation 1 2 0 0.0169148 GO:0046592 polyamine oxidase activity 14 2728 23.1 0.0177308 u GO:0007165 signal transduction 2 25 0.2 0.0188921 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5 181 1.5 0.0190844 GO:0009308 amine metabolism 4 120 1 0.0191227 GO:0006091 energy pathways 2 27 0.2 0.0218621 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2 27 0.2 0.0218621 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 2 29 0.2 0.0250116 GO:0009310 amine catabolism 6 264 2.2 0.0251047 GO:0016567 protein ubiquitination 1 3 0 0.0252655 GO:0000320 re-entry into mitotic cell cycle 1 3 0 0.0252655 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 1 3 0 0.0252655 GO:0004652 polynucleotide adenylyltransferase activity 1 3 0 0.0252655 GO:0004690 cyclic nucleotide-dependent protein kinase activity 1 3 0 0.0252655 GO:0004774 succinate-CoA ligase activity 1 3 0 0.0252655 GO:0004818 glutamate-tRNA ligase activity 1 3 0 0.0252655 GO:0004828 serine-tRNA ligase activity 1 3 0 0.0252655 GO:0005869 dynactin complex 1 3 0 0.0252655 GO:0006424 glutamyl-tRNA aminoacylation 1 3 0 0.0252655 GO:0006434 seryl-tRNA aminoacylation 1 3 0 0.0252655 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor 1 3 0 0.0252655 GO:0043149 stress fiber formation 1 3 0 0.0252655 GO:0048041 focal adhesion formation 9 496 4.2 0.025408 GO:0004672 protein kinase activity 4 131 1.1 0.0254224 GO:0003774 motor activity 4 132 1.1 0.02605 GO:0006520 amino acid metabolism 6 268 2.2 0.0267682 GO:0000151 ubiquitin ligase complex 11 669 5.6 0.0268991 GO:0006793 phosphorus metabolism 11 669 5.6 0.0268991 GO:0006796 phosphate metabolism 4 1147 9.7 0.0289795 u GO:0005215 transporter activity 82 8414 71.4 0.0291215 GO:0007582 physiological process 5 204 1.7 0.0300132 GO:0007010 cytoskeleton organization and biogenesis 12 771 6.5 0.0307349 GO:0016772 transferase activity, transferring phosphorus-containing groups 7 358 3 0.0329753 GO:0015031 protein transport 1 4 0 0.0335458 GO:0000103 sulfate assimilation 1 4 0 0.0335458 GO:0001515 opioid peptide activity 1 4 0 0.0335458 GO:0003997 acyl-CoA oxidase activity 1 4 0 0.0335458 GO:0004449 isocitrate dehydrogenase (NAD+) activity 1 4 0 0.0335458 GO:0006791 sulfur utilization 1 4 0 0.0335458 GO:0007435 salivary gland morphogenesis 1 4 0 0.0335458 GO:0008088 axon cargo transport 1 4 0 0.0335458 GO:0009895 negative regulation of catabolism 1 4 0 0.0335458 GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors 1 4 0 0.0335458 GO:0045639 positive regulation of myeloid blood cell differentiation 1 4 0 0.0335458 GO:0045767 regulation of anti-apoptosis 3 84 0.7 0.0346348 GO:0007017 microtubule-based process 31 2670 22.6 0.037143 GO:0005634 nucleus 3 88 0.7 0.0389372 GO:0006092 main pathways of carbohydrate metabolism 2 38 0.3 0.0412282 GO:0007018 microtubule-based movement 2 38 0.3 0.0412282 GO:0030705 cytoskeleton-dependent intracellular transport 1 5 0 0.0417564 GO:0000145 exocyst 1 5 0 0.0417564 GO:0004287 prolyl oligopeptidase activity 1 5 0 0.0417564 GO:0004396 hexokinase activity 1 5 0 0.0417564 GO:0004576 oligosaccharyl transferase activity 1 5 0 0.0417564 GO:0006572 tyrosine catabolism 1 5 0 0.0417564 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0417564 GO:0030516 regulation of axon extension 1 5 0 0.0417564 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0417564 GO:0030866 cortical actin cytoskeleton organization and biogenesis 23 1874 15.9 0.0425369 GO:0046872 metal ion binding 2 39 0.3 0.0432205 GO:0006418 tRNA aminoacylation for protein translation 2 39 0.3 0.0432205 GO:0043038 amino acid activation 2 39 0.3 0.0432205 GO:0043039 tRNA aminoacylation 2 41 0.3 0.0473104 GO:0004812 tRNA ligase activity 2 41 0.3 0.0473104 GO:0008452 RNA ligase activity 2 41 0.3 0.0473104 GO:0016875 ligase activity, forming carbon-oxygen bonds 2 41 0.3 0.0473104 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 19 3170 26.9 0.0473803 u GO:0007154 cell communication 2 42 0.3 0.0494064 GO:0006400 tRNA modification 1 6 0 0.0498978 GO:0001658 ureteric bud branching 1 6 0 0.0498978 GO:0001704 formation of primary germ layer 1 6 0 0.0498978 GO:0001707 mesoderm formation 1 6 0 0.0498978 GO:0001725 stress fiber 1 6 0 0.0498978 GO:0003756 protein disulfide isomerase activity 1 6 0 0.0498978 GO:0004448 isocitrate dehydrogenase activity 1 6 0 0.0498978 GO:0006559 phenylalanine catabolism 1 6 0 0.0498978 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0498978 GO:0007431 salivary gland development 1 6 0 0.0498978 GO:0008215 spermine metabolism 1 6 0 0.0498978 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1 6 0 0.0498978 GO:0042176 regulation of protein catabolism 1 6 0 0.0498978 GO:0042577 lipid phosphatase activity 1 6 0 0.0498978 GO:0048332 mesoderm morphogenesis 3 102 0.8 0.0560094 GO:0006511 ubiquitin-dependent protein catabolism 3 102 0.8 0.0560094 GO:0019941 modification-dependent protein catabolism 3 102 0.8 0.0560094 GO:0045202 synapse 5 243 2 0.0561965 GO:0042578 phosphoric ester hydrolase activity 5 244 2 0.0569993 GO:0006996 organelle organization and biogenesis 1 7 0 0.0579706 GO:0005388 calcium-transporting ATPase activity 1 7 0 0.0579706 GO:0006558 L-phenylalanine metabolism 1 7 0 0.0579706 GO:0006564 L-serine biosynthesis 1 7 0 0.0579706 GO:0009074 aromatic amino acid family catabolism 1 7 0 0.0579706 GO:0015085 calcium ion transporter activity 1 7 0 0.0579706 GO:0016405 CoA-ligase activity 1 7 0 0.0579706 GO:0016878 acid-thiol ligase activity 1 7 0 0.0579706 GO:0042402 biogenic amine catabolism 1 7 0 0.0579706 GO:0051017 actin filament bundle formation 2 46 0.3 0.0581151 GO:0006606 protein-nucleus import 2 47 0.3 0.0603699 GO:0016886 ligase activity, forming phosphoric ester bonds 2 48 0.4 0.0626544 GO:0006096 glycolysis 2 49 0.4 0.064968 GO:0009451 RNA modification 1 8 0 0.0659754 GO:0005871 kinesin complex 1 8 0 0.0659754 GO:0006635 fatty acid beta-oxidation 1 8 0 0.0659754 GO:0007595 lactation 1 8 0 0.0659754 GO:0015035 protein disulfide oxidoreductase activity 1 8 0 0.0659754 GO:0019905 syntaxin binding 1 8 0 0.0659754 GO:0030218 erythrocyte differentiation 1 8 0 0.0659754 GO:0030659 cytoplasmic vesicle membrane 1 8 0 0.0659754 GO:0042219 amino acid derivative catabolism 9 594 5 0.0659912 GO:0016788 hydrolase activity, acting on ester bonds 6 337 2.8 0.0674751 GO:0006118 electron transport 8 509 4.3 0.0682479 GO:0006468 protein amino acid phosphorylation 9 599 5 0.0687807 GO:0016491 oxidoreductase activity 2 51 0.4 0.0696797 GO:0005941 unlocalized 2 51 0.4 0.0696797 GO:0016042 lipid catabolism 3 112 0.9 0.0700363 GO:0006357 regulation of transcription from Pol II promoter 3 112 0.9 0.0700363 GO:0016311 dephosphorylation 5 262 2.2 0.0725781 GO:0019752 carboxylic acid metabolism 1 9 0 0.0739127 GO:0000086 G2/M transition of mitotic cell cycle 1 9 0 0.0739127 GO:0000781 chromosome, telomeric region 1 9 0 0.0739127 GO:0007004 telomerase-dependent telomere maintenance 1 9 0 0.0739127 GO:0009618 response to pathogenic bacteria 1 9 0 0.0739127 GO:0009894 regulation of catabolism 1 9 0 0.0739127 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1 9 0 0.0739127 GO:0017124 SH3 domain binding 1 9 0 0.0739127 GO:0019439 aromatic compound catabolism 5 265 2.2 0.0753813 GO:0006082 organic acid metabolism 3 118 1 0.079141 GO:0000278 mitotic cell cycle 2 55 0.4 0.0794239 GO:0004221 ubiquitin thiolesterase activity 3 119 1 0.0807066 GO:0007243 protein kinase cascade 3 119 1 0.0807066 GO:0009790 embryonic development 1 480 4 0.0816059 u GO:0006952 defense response 1 10 0 0.0817832 GO:0001763 branching morphogenesis 1 10 0 0.0817832 GO:0005913 cell-cell adherens junction 1 10 0 0.0817832 GO:0006563 L-serine metabolism 1 10 0 0.0817832 GO:0009070 serine family amino acid biosynthesis 1 10 0 0.0817832 GO:0016358 dendrite morphogenesis 2 56 0.4 0.0819232 GO:0006007 glucose catabolism 2 57 0.4 0.0844466 GO:0004843 ubiquitin-specific protease activity 2 57 0.4 0.0844466 GO:0019320 hexose catabolism 2 57 0.4 0.0844466 GO:0046164 alcohol catabolism 2 57 0.4 0.0844466 GO:0046365 monosaccharide catabolism 9 632 5.3 0.0890454 GO:0005739 mitochondrion 2 59 0.5 0.0895634 GO:0005635 nuclear membrane 2 59 0.5 0.0895634 GO:0008081 phosphoric diester hydrolase activity 1 11 0 0.0895873 GO:0000149 SNARE binding 1 11 0 0.0895873 GO:0001657 ureteric bud development 1 11 0 0.0895873 GO:0004602 glutathione peroxidase activity 1 11 0 0.0895873 GO:0005158 insulin receptor binding 1 11 0 0.0895873 GO:0006595 polyamine metabolism 1 11 0 0.0895873 GO:0007586 digestion 1 11 0 0.0895873 GO:0008645 hexose transport 1 11 0 0.0895873 GO:0015749 monosaccharide transport 1 11 0 0.0895873 GO:0015758 glucose transport 1 11 0 0.0895873 GO:0042472 inner ear morphogenesis 1 11 0 0.0895873 GO:0051052 regulation of DNA metabolism 4 200 1.6 0.0907577 GO:0005829 cytosol 3 127 1 0.0937067 GO:0043037 translation 3 128 1 0.0953894 GO:0004721 phosphoprotein phosphatase activity 5 286 2.4 0.0966211 GO:0007028 cytoplasm organization and biogenesis 1 12 0.1 0.0973256 GO:0000315 organellar large ribosomal subunit 1 12 0.1 0.0973256 GO:0004179 membrane alanyl aminopeptidase activity 1 12 0.1 0.0973256 GO:0005762 mitochondrial large ribosomal subunit 1 12 0.1 0.0973256 GO:0006487 N-linked glycosylation 1 12 0.1 0.0973256 GO:0006570 tyrosine metabolism 1 12 0.1 0.0973256 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0.1 0.0973256 GO:0016284 alanine aminopeptidase activity 1 12 0.1 0.0973256 GO:0042471 ear morphogenesis 2 620 5.2 0.097838 u GO:0006811 ion transport 2 63 0.5 0.100061 GO:0030036 actin cytoskeleton organization and biogenesis 2 64 0.5 0.102737 GO:0016052 carbohydrate catabolism 8 559 4.7 0.1032 GO:0016310 phosphorylation 1 13 0.1 0.104999 GO:0005938 cell cortex 1 13 0.1 0.104999 GO:0006446 regulation of translational initiation 1 13 0.1 0.104999 GO:0007498 mesoderm development 1 13 0.1 0.104999 GO:0007548 sex differentiation 1 13 0.1 0.104999 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 1 13 0.1 0.104999 GO:0016877 ligase activity, forming carbon-sulfur bonds 1 13 0.1 0.104999 GO:0016998 cell wall catabolism 1 13 0.1 0.104999 GO:0019395 fatty acid oxidation 1 13 0.1 0.104999 GO:0042493 response to drug 1 13 0.1 0.104999 GO:0045121 lipid raft 2 65 0.5 0.105433 GO:0006399 tRNA metabolism 2 67 0.5 0.110882 GO:0030029 actin filament-based process 1 14 0.1 0.112607 GO:0000723 telomere maintenance 1 14 0.1 0.112607 GO:0005924 cell-substrate adherens junction 1 14 0.1 0.112607 GO:0006700 C21-steroid hormone biosynthesis 1 14 0.1 0.112607 GO:0009069 serine family amino acid metabolism 1 14 0.1 0.112607 GO:0012506 vesicle membrane 3 139 1.1 0.114692 GO:0030695 GTPase regulator activity 2 69 0.5 0.116404 GO:0016790 thiolester hydrolase activity 3 141 1.1 0.118351 GO:0000287 magnesium ion binding 2 70 0.5 0.11919 GO:0006816 calcium ion transport 1 15 0.1 0.120151 GO:0000059 protein-nucleus import, docking 1 15 0.1 0.120151 GO:0004759 serine esterase activity 1 15 0.1 0.120151 GO:0008207 C21-steroid hormone metabolism 1 15 0.1 0.120151 GO:0045637 regulation of myeloid blood cell differentiation 4 222 1.8 0.120503 GO:0008092 cytoskeletal protein binding 1 420 3.5 0.124009 u GO:0006955 immune response 7 491 4.1 0.124571 GO:0007049 cell cycle 4 879 7.4 0.125401 u GO:0009605 response to external stimulus 2 578 4.9 0.126098 u GO:0009607 response to biotic stimulus 1 16 0.1 0.127632 GO:0006289 nucleotide-excision repair 1 16 0.1 0.127632 GO:0007059 chromosome segregation 1 16 0.1 0.127632 GO:0030055 cell-matrix junction 1 16 0.1 0.127632 GO:0030176 integral to endoplasmic reticulum membrane 3 146 1.2 0.127685 GO:0006366 transcription from Pol II promoter 2 75 0.6 0.133364 GO:0006006 glucose metabolism 2 75 0.6 0.133364 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 3 149 1.2 0.133408 GO:0006974 response to DNA damage stimulus 1 17 0.1 0.13505 GO:0016323 basolateral plasma membrane 13 1095 9.3 0.137386 GO:0008270 zinc ion binding 5 321 2.7 0.137975 GO:0046907 intracellular transport 1 18 0.1 0.142405 GO:0001656 metanephros development 1 18 0.1 0.142405 GO:0001822 kidney development 1 18 0.1 0.142405 GO:0004437 inositol/phosphatidylinositol phosphatase activity 1 18 0.1 0.142405 GO:0007015 actin filament organization 1 18 0.1 0.142405 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1 18 0.1 0.142405 GO:0042446 hormone biosynthesis 22 2048 17.3 0.143047 GO:0050789 regulation of biological process 4 238 2 0.14445 GO:0016070 RNA metabolism 5 327 2.7 0.145754 GO:0005783 endoplasmic reticulum 3 157 1.3 0.149094 GO:0009719 response to endogenous stimulus 1 19 0.1 0.149698 GO:0000313 organellar ribosome 1 19 0.1 0.149698 GO:0001655 urogenital system development 1 19 0.1 0.149698 GO:0005761 mitochondrial ribosome 1 19 0.1 0.149698 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0.1 0.149698 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0.1 0.149698 GO:0009072 aromatic amino acid family metabolism 1 19 0.1 0.149698 GO:0030286 dynein complex 7 517 4.3 0.150635 GO:0006950 response to stress 14 1221 10.3 0.153302 GO:0046914 transition metal ion binding 1 20 0.1 0.156929 GO:0004091 carboxylesterase activity 1 20 0.1 0.156929 GO:0007369 gastrulation 1 20 0.1 0.156929 GO:0019200 carbohydrate kinase activity 1 20 0.1 0.156929 GO:0045597 positive regulation of cell differentiation 2 85 0.7 0.162733 GO:0006913 nucleocytoplasmic transport 1 21 0.1 0.1641 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0.1 0.1641 GO:0004129 cytochrome-c oxidase activity 1 21 0.1 0.1641 GO:0015002 heme-copper terminal oxidase activity 1 21 0.1 0.1641 GO:0016675 oxidoreductase activity, acting on heme group of donors 1 21 0.1 0.1641 GO:0016676 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 2 86 0.7 0.165733 GO:0006725 aromatic compound metabolism 1 22 0.1 0.17121 GO:0004364 glutathione transferase activity 1 22 0.1 0.17121 GO:0019901 protein kinase binding 1 22 0.1 0.17121 GO:0046982 protein heterodimerization activity 2 90 0.7 0.177825 GO:0008047 enzyme activator activity 1 23 0.1 0.17826 GO:0009063 amino acid catabolism 2 91 0.7 0.18087 GO:0019318 hexose metabolism 2 92 0.7 0.183923 GO:0005083 small GTPase regulatory/interacting protein activity 22 3131 26.5 0.184127 u GO:0050875 cellular physiological process 1 24 0.2 0.18525 GO:0003777 microtubule motor activity 1 24 0.2 0.18525 GO:0006112 energy reserve metabolism 1 24 0.2 0.18525 GO:0015082 di-, tri-valent inorganic cation transporter activity 1 24 0.2 0.18525 GO:0019900 kinase binding 1 24 0.2 0.18525 GO:0019933 cAMP-mediated signaling 1 24 0.2 0.18525 GO:0030100 regulation of endocytosis 2 93 0.7 0.186983 GO:0005996 monosaccharide metabolism 2 93 0.7 0.186983 GO:0006605 protein targeting 1 25 0.2 0.192182 GO:0008017 microtubule binding 1 25 0.2 0.192182 GO:0009617 response to bacteria 2 97 0.8 0.199293 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 27 0.2 0.20587 GO:0005759 mitochondrial matrix 1 27 0.2 0.20587 GO:0008643 carbohydrate transport 3 634 5.3 0.207409 u GO:0005886 plasma membrane 3 187 1.5 0.212417 GO:0016791 phosphoric monoester hydrolase activity 1 28 0.2 0.212628 GO:0004177 aminopeptidase activity 1 28 0.2 0.212628 GO:0005643 nuclear pore 1 28 0.2 0.212628 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1 28 0.2 0.212628 GO:0019935 cyclic-nucleotide-mediated signaling 1 28 0.2 0.212628 GO:0046930 pore complex 4 280 2.3 0.214827 GO:0005794 Golgi apparatus 2 103 0.8 0.217931 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1 29 0.2 0.219328 GO:0015934 large ribosomal subunit 7 582 4.9 0.22558 GO:0016043 cell organization and biogenesis 1 30 0.2 0.225972 GO:0015631 tubulin binding 5 384 3.2 0.227938 GO:0030234 enzyme regulator activity 1 31 0.2 0.23256 GO:0015036 disulfide oxidoreductase activity 1 31 0.2 0.23256 GO:0050876 reproductive physiological process 5 390 3.3 0.237312 GO:0007155 cell adhesion 1 32 0.2 0.239092 GO:0005912 adherens junction 1 32 0.2 0.239092 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1 32 0.2 0.239092 GO:0018193 peptidyl-amino acid modification 1 32 0.2 0.239092 GO:0019904 protein domain specific binding 2 110 0.9 0.239856 GO:0006470 protein amino acid dephosphorylation 2 110 0.9 0.239856 GO:0015674 di-, tri-valent inorganic cation transport 1 33 0.2 0.24557 GO:0003702 RNA polymerase II transcription factor activity 1 33 0.2 0.24557 GO:0005200 structural constituent of cytoskeleton 1 33 0.2 0.24557 GO:0016860 intramolecular oxidoreductase activity 16 1564 13.2 0.25162 GO:0019222 regulation of metabolism 6 500 4.2 0.25166 GO:0005509 calcium ion binding 1 34 0.2 0.251992 GO:0006887 exocytosis 1 34 0.2 0.251992 GO:0008652 amino acid biosynthesis 1 34 0.2 0.251992 GO:0009888 histogenesis 1 34 0.2 0.251992 GO:0016859 cis-trans isomerase activity 15 1458 12.3 0.254219 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 4 723 6.1 0.258362 u GO:0005576 extracellular 18 1795 15.2 0.260653 GO:0016787 hydrolase activity 7 610 5.1 0.261355 GO:0030163 protein catabolism 2 117 0.9 0.261887 GO:0008234 cysteine-type peptidase activity 2 118 1 0.265038 GO:0007167 enzyme linked receptor protein signaling pathway 7 613 5.2 0.265286 GO:0009057 macromolecule catabolism 1 37 0.3 0.270936 GO:0006576 biogenic amine metabolism 1 37 0.3 0.270936 GO:0007411 axon guidance 1 37 0.3 0.270936 GO:0019932 second-messenger-mediated signaling 7 619 5.2 0.273199 GO:0008283 cell proliferation 14 1372 11.6 0.274453 GO:0016740 transferase activity 2 121 1 0.27449 GO:0016853 isomerase activity 1 38 0.3 0.277144 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2 122 1 0.27764 GO:0007268 synaptic transmission 7 625 5.3 0.281175 GO:0005198 structural molecule activity 3 218 1.8 0.282699 GO:0006886 intracellular protein transport 1 39 0.3 0.2833 GO:0030099 myeloid blood cell differentiation 1 39 0.3 0.2833 GO:0042445 hormone metabolism 2 433 3.6 0.283581 u GO:0005102 receptor binding 16 1604 13.6 0.284987 GO:0003677 DNA binding 16 1606 13.6 0.286696 GO:0050791 regulation of physiological process 1 40 0.3 0.289404 GO:0000165 MAPKKK cascade 1 40 0.3 0.289404 GO:0006445 regulation of translation 14 1393 11.8 0.293606 GO:0006355 regulation of transcription, DNA-dependent 1 41 0.3 0.295457 GO:0003682 chromatin binding 1 41 0.3 0.295457 GO:0006694 steroid biosynthesis 2 128 1 0.296518 GO:0019226 transmission of nerve impulse 2 128 1 0.296518 GO:0050905 neuromuscular physiological process 1 42 0.3 0.301458 GO:0006413 translational initiation 1 42 0.3 0.301458 GO:0030145 manganese ion binding 2 130 1.1 0.302797 GO:0015629 actin cytoskeleton 15 1516 12.8 0.304941 GO:0006350 transcription 2 131 1.1 0.305934 GO:0015399 primary active transporter activity 1 43 0.3 0.307408 GO:0006790 sulfur metabolism 1 44 0.3 0.313309 GO:0000122 negative regulation of transcription from Pol II promoter 1 44 0.3 0.313309 GO:0007420 brain development 14 1417 12 0.315998 GO:0006351 transcription, DNA-dependent 1 45 0.3 0.319159 GO:0006575 amino acid derivative metabolism 2 136 1.1 0.321573 GO:0016779 nucleotidyltransferase activity 1 46 0.3 0.32496 GO:0009795 embryonic morphogenesis 5 444 3.7 0.325565 GO:0006412 protein biosynthesis 7 660 5.6 0.32876 GO:0007242 intracellular signaling cascade 1 47 0.3 0.330712 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1 47 0.3 0.330712 GO:0045211 postsynaptic membrane 1 48 0.4 0.336415 GO:0008235 metalloexopeptidase activity 2 399 3.3 0.336917 u GO:0006812 cation transport 12 1656 14 0.338574 u GO:0006810 transport 21 2750 23.3 0.340759 u GO:0008151 cell growth and/or maintenance 1 49 0.4 0.34207 GO:0051049 regulation of transport 4 350 2.9 0.346491 GO:0006629 lipid metabolism 14 1452 12.3 0.34945 GO:0045449 regulation of transcription 1 51 0.4 0.353238 GO:0046873 metal ion transporter activity 1 52 0.4 0.358751 GO:0045786 negative regulation of cell cycle 1 53 0.4 0.364217 GO:0009309 amine biosynthesis 1 53 0.4 0.364217 GO:0019899 enzyme binding 2 151 1.2 0.367906 GO:0007267 cell-cell signaling 6 884 7.5 0.369521 u GO:0050874 organismal physiological process 1 54 0.4 0.369637 GO:0005777 peroxisome 1 54 0.4 0.369637 GO:0042579 microbody 2 152 1.2 0.370955 GO:0000067 DNA replication and chromosome cycle 3 505 4.2 0.373908 u GO:0006259 DNA metabolism 1 55 0.4 0.375011 GO:0007160 cell-matrix adhesion 3 259 2.1 0.377913 GO:0007399 neurogenesis 1 56 0.4 0.38034 GO:0016563 transcriptional activator activity 7 698 5.9 0.381755 GO:0009887 organogenesis 1 57 0.4 0.385624 GO:0009792 embryonic development (sensu Animalia) 1 57 0.4 0.385624 GO:0015992 proton transport 76 9173 77.9 0.390116 u GO:0005623 cell 1 58 0.4 0.390863 GO:0005730 nucleolus 1 58 0.4 0.390863 GO:0006818 hydrogen transport 1 58 0.4 0.390863 GO:0006916 anti-apoptosis 2 159 1.3 0.392132 GO:0006066 alcohol metabolism 4 375 3.1 0.394823 GO:0003723 RNA binding 2 160 1.3 0.395132 GO:0003779 actin binding 1 238 2 0.396771 u GO:0042623 ATPase activity, coupled 21 2672 22.6 0.398586 u GO:0003676 nucleic acid binding 2 162 1.3 0.401112 GO:0004713 protein-tyrosine kinase activity 1 60 0.5 0.401209 GO:0046983 protein dimerization activity 3 270 2.2 0.403205 GO:0005578 extracellular matrix 1 235 1.9 0.403711 u GO:0009613 response to pest/pathogen/parasite 2 165 1.4 0.410031 GO:0005624 membrane fraction 10 1058 8.9 0.410524 GO:0050896 response to stimulus 1 62 0.5 0.41138 GO:0005096 GTPase activator activity 1 62 0.5 0.41138 GO:0007417 central nervous system development 1 230 1.9 0.415474 u GO:0015672 monovalent inorganic cation transport 1 63 0.5 0.416402 GO:0006486 protein amino acid glycosylation 1 63 0.5 0.416402 GO:0007409 axonogenesis 1 63 0.5 0.416402 GO:0016568 chromatin modification 1 64 0.5 0.421381 GO:0003743 translation initiation factor activity 2 170 1.4 0.424752 GO:0008324 cation transporter activity 2 348 2.9 0.42958 u GO:0016817 hydrolase activity, acting on acid anhydrides 1 66 0.5 0.431212 GO:0043066 negative regulation of apoptosis 1 66 0.5 0.431212 GO:0043069 negative regulation of programmed cell death 2 346 2.9 0.433513 u GO:0016265 death 6 622 5.2 0.434798 GO:0008233 peptidase activity 2 345 2.9 0.435488 u GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 67 0.5 0.436066 GO:0045892 negative regulation of transcription, DNA-dependent 2 343 2.9 0.439453 u GO:0008219 cell death 3 286 2.4 0.439458 GO:0005525 GTP binding 1 69 0.5 0.44565 GO:0009101 glycoprotein biosynthesis 1 69 0.5 0.44565 GO:0045045 secretory pathway 1 70 0.5 0.450381 GO:0045595 regulation of cell differentiation 11 1415 12 0.452906 u GO:0007275 development 2 180 1.5 0.453615 GO:0000267 cell fraction 3 293 2.4 0.455066 GO:0005975 carbohydrate metabolism 3 456 3.8 0.455069 u GO:0004175 endopeptidase activity 1 71 0.6 0.455072 GO:0042625 ATPase activity, coupled to transmembrane movement of ions 2 181 1.5 0.456457 GO:0007001 chromosome organization and biogenesis (sensu Eukarya) 3 294 2.4 0.457282 GO:0019001 guanyl nucleotide binding 2 183 1.5 0.462115 GO:0050879 organismal movement 1 211 1.7 0.462427 u GO:0004518 nuclease activity 1 211 1.7 0.462427 u GO:0009581 detection of external stimulus 1 209 1.7 0.467574 u GO:0005694 chromosome 2 185 1.5 0.467739 GO:0006396 RNA processing 1 74 0.6 0.468909 GO:0001501 skeletal development 2 187 1.5 0.473329 GO:0006997 nuclear organization and biogenesis 1 204 1.7 0.480609 u GO:0007264 small GTPase mediated signal transduction 1 204 1.7 0.480609 u GO:0009628 response to abiotic stimulus 1 77 0.6 0.482397 GO:0009100 glycoprotein metabolism 1 203 1.7 0.483245 u GO:0000003 reproduction 1 203 1.7 0.483245 u GO:0019953 sexual reproduction 7 776 6.5 0.490679 GO:0030528 transcription regulator activity 1 79 0.6 0.4912 GO:0009966 regulation of signal transduction 1 199 1.6 0.493881 u GO:0003735 structural constituent of ribosome 1 197 1.6 0.499255 u GO:0007600 sensory perception 1 81 0.6 0.499855 GO:0000087 M phase of mitotic cell cycle 1 81 0.6 0.499855 GO:0005743 mitochondrial inner membrane 1 81 0.6 0.499855 GO:0007067 mitosis 2 313 2.6 0.501373 u GO:0012501 programmed cell death 2 198 1.6 0.503437 GO:0000074 regulation of cell cycle 1 82 0.6 0.504127 GO:0008202 steroid metabolism 2 311 2.6 0.505654 u GO:0005386 carrier activity 1 83 0.7 0.508363 GO:0007156 homophilic cell adhesion 1 83 0.7 0.508363 GO:0008238 exopeptidase activity 1 83 0.7 0.508363 GO:0016789 carboxylic ester hydrolase activity 2 309 2.6 0.509952 u GO:0006915 apoptosis 3 319 2.7 0.51136 GO:0050877 neurophysiological process 1 85 0.7 0.516728 GO:0015405 P-P-bond-hydrolysis-driven transporter activity 1 187 1.5 0.526671 u GO:0016757 transferase activity, transferring glycosyl groups 1 88 0.7 0.529011 GO:0006417 regulation of protein biosynthesis 2 297 2.5 0.536094 u GO:0030001 metal ion transport 7 872 7.4 0.536331 u GO:0009058 biosynthesis 2 212 1.8 0.540133 GO:0016192 vesicle-mediated transport 1 91 0.7 0.540985 GO:0004867 serine-type endopeptidase inhibitor activity 2 294 2.4 0.542718 u GO:0030154 cell differentiation 20 2374 20.1 0.543494 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 92 0.7 0.544909 GO:0006631 fatty acid metabolism 1 92 0.7 0.544909 GO:0009889 regulation of biosynthesis 1 178 1.5 0.552093 u GO:0007276 gametogenesis 7 822 6.9 0.552528 GO:0009653 morphogenesis 1 95 0.8 0.556482 GO:0007283 spermatogenesis 1 95 0.8 0.556482 GO:0048232 male gamete generation 1 176 1.4 0.557834 u GO:0004857 enzyme inhibitor activity 1 96 0.8 0.560274 GO:0004197 cysteine-type endopeptidase activity 1 96 0.8 0.560274 GO:0005911 intercellular junction 1 96 0.8 0.560274 GO:0008135 translation factor activity, nucleic acid binding 1 174 1.4 0.563608 u GO:0043067 regulation of programmed cell death 1 97 0.8 0.564034 GO:0006397 mRNA processing 1 172 1.4 0.569413 u GO:0042981 regulation of apoptosis 2 224 1.9 0.570082 GO:0015075 ion transporter activity 1 99 0.8 0.571459 GO:0045182 translation regulator activity 1 100 0.8 0.575125 GO:0015078 hydrogen ion transporter activity 1 169 1.4 0.578178 u GO:0008236 serine-type peptidase activity 1 101 0.8 0.578759 GO:0008565 protein transporter activity 6 724 6.1 0.581707 u GO:0009059 macromolecule biosynthesis 1 102 0.8 0.582362 GO:0019866 inner membrane 2 276 2.3 0.583116 u GO:0030529 ribonucleoprotein complex 1 103 0.8 0.585935 GO:0015077 monovalent inorganic cation transporter activity 1 103 0.8 0.585935 GO:0016481 negative regulation of transcription 4 496 4.2 0.586502 u GO:0050794 regulation of cellular process 1 166 1.4 0.58701 u GO:0005840 ribosome 1 166 1.4 0.58701 u GO:0006457 protein folding 1 106 0.9 0.596473 GO:0016071 mRNA metabolism 1 106 0.9 0.596473 GO:0016477 cell migration 1 107 0.9 0.599926 GO:0030097 hemopoiesis 1 107 0.9 0.599926 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 108 0.9 0.60335 GO:0006333 chromatin assembly/disassembly 5 596 5 0.604872 u GO:0003700 transcription factor activity 1 109 0.9 0.606745 GO:0005740 mitochondrial membrane 1 110 0.9 0.610111 GO:0000280 nuclear division 1 110 0.9 0.610111 GO:0016758 transferase activity, transferring hexosyl groups 1 158 1.3 0.610875 u GO:0006323 DNA packaging 1 158 1.3 0.610875 u GO:0006325 establishment and/or maintenance of chromatin architecture 1 158 1.3 0.610875 u GO:0006928 cell motility 1 158 1.3 0.610875 u GO:0008237 metallopeptidase activity 1 111 0.9 0.613448 GO:0016327 apicolateral plasma membrane 1 157 1.3 0.613888 u GO:0004252 serine-type endopeptidase activity 5 590 5 0.614045 u GO:0006508 proteolysis and peptidolysis 1 113 0.9 0.620038 GO:0016337 cell-cell adhesion 1 115 0.9 0.626517 GO:0000279 M phase 1 117 0.9 0.632886 GO:0006897 endocytosis 2 250 2.1 0.642933 u GO:0016887 ATPase activity 1 144 1.2 0.653588 u GO:0050793 regulation of development 1 141 1.1 0.662872 u GO:0008610 lipid biosynthesis 1 139 1.1 0.669082 u GO:0016023 cytoplasmic vesicle 1 132 1.1 0.690933 u GO:0030414 protease inhibitor activity 1 131 1.1 0.694066 u GO:0004866 endopeptidase inhibitor activity 1 130 1.1 0.697203 u GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1 129 1 0.700341 u GO:0006260 DNA replication 1 127 1 0.706624 u GO:0009892 negative regulation of metabolism 1 127 1 0.706624 u GO:0042626 ATPase activity, coupled to transmembrane movement of substances 1 125 1 0.712915 u GO:0006281 DNA repair 1 125 1 0.712915 u GO:0019012 virion 1 124 1 0.716062 u GO:0019028 viral capsid 1 123 1 0.71921 u GO:0005489 electron transporter activity 1 123 1 0.71921 u GO:0042221 response to chemical substance 1 119 1 0.731811 u GO:0030054 cell junction