# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 53 #b referenced loci : 50 #c annotated loci : 36 #d hyper-geometric : n 36 hgN 14129 #e k hgK Exp k p-value term description 28 7041 17.9 0.000549086 GO:0005488 binding 2 24 0 0.00168178 GO:0030100 regulation of endocytosis 4 212 0.5 0.00199225 GO:0016192 vesicle-mediated transport 3 117 0.2 0.00323807 GO:0006897 endocytosis 12 2064 5.2 0.00378201 GO:0005515 protein binding 1 2 0 0.00508959 GO:0000209 protein polyubiquitination 1 2 0 0.00508959 GO:0001786 phosphatidylserine binding 1 2 0 0.00508959 GO:0004020 adenylyl-sulfate kinase activity 1 2 0 0.00508959 GO:0004779 sulfate adenylyltransferase activity 1 2 0 0.00508959 GO:0004781 sulfate adenylyltransferase (ATP) activity 1 2 0 0.00508959 GO:0008429 phosphatidylethanolamine binding 2 49 0.1 0.00688528 GO:0051049 regulation of transport 1 3 0 0.00762493 GO:0004652 polynucleotide adenylyltransferase activity 1 3 0 0.00762493 GO:0042147 retrograde transport, endosome to Golgi 1 3 0 0.00762493 GO:0043149 stress fiber formation 1 3 0 0.00762493 GO:0045806 negative regulation of endocytosis 1 3 0 0.00762493 GO:0048041 focal adhesion formation 1 4 0 0.010154 GO:0000103 sulfate assimilation 1 4 0 0.010154 GO:0003997 acyl-CoA oxidase activity 1 4 0 0.010154 GO:0006791 sulfur utilization 1 4 0 0.010154 GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors 3 3552 9 0.0104645 u GO:0016021 integral to membrane 6 749 1.9 0.0108476 GO:0016301 kinase activity 4 350 0.8 0.0116721 GO:0006629 lipid metabolism 1 5 0 0.0126768 GO:0004287 prolyl oligopeptidase activity 1 5 0 0.0126768 GO:0006910 phagocytosis, recognition 1 5 0 0.0126768 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0126768 GO:0017137 Rab interactor activity 1 6 0 0.0151933 GO:0001725 stress fiber 1 6 0 0.0151933 GO:0051051 negative regulation of transport 7 1067 2.7 0.0165623 GO:0005524 ATP binding 28 8414 21.4 0.0171167 GO:0007582 physiological process 7 1078 2.7 0.0174403 GO:0030554 adenyl nucleotide binding 1 7 0 0.0177036 GO:0045444 adipocyte differentiation 1 7 0 0.0177036 GO:0051017 actin filament bundle formation 18 4537 11.5 0.0191965 GO:0003824 catalytic activity 1 8 0 0.0202077 GO:0006635 fatty acid beta-oxidation 1 8 0 0.0202077 GO:0006911 phagocytosis, engulfment 1 8 0 0.0202077 GO:0019905 syntaxin binding 9 1656 4.2 0.0203688 GO:0006810 transport 1 9 0 0.0227056 GO:0000086 G2/M transition of mitotic cell cycle 1 9 0 0.0227056 GO:0009618 response to pathogenic bacteria 1 9 0 0.0227056 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2 92 0.2 0.0228895 GO:0005083 small GTPase regulatory/interacting protein activity 8 1415 3.6 0.0235408 GO:0007275 development 7 1161 2.9 0.0251738 GO:0006464 protein modification 1 10 0 0.0251973 GO:0005178 integrin binding 1 10 0 0.0251973 GO:0005913 cell-cell adherens junction 1 10 0 0.0251973 GO:0016358 dendrite morphogenesis 2 97 0.2 0.0252587 GO:0006397 mRNA processing 1 11 0 0.0276828 GO:0000149 SNARE binding 1 11 0 0.0276828 GO:0005158 insulin receptor binding 1 11 0 0.0276828 GO:0005802 Golgi trans face 1 11 0 0.0276828 GO:0008645 hexose transport 1 11 0 0.0276828 GO:0015749 monosaccharide transport 1 11 0 0.0276828 GO:0015758 glucose transport 21 5837 14.8 0.0291518 GO:0008152 metabolism 3 264 0.6 0.0292597 GO:0016567 protein ubiquitination 2 106 0.2 0.0297634 GO:0016071 mRNA metabolism 1 12 0 0.0301621 GO:0004179 membrane alanyl aminopeptidase activity 1 12 0 0.0301621 GO:0016284 alanine aminopeptidase activity 1 12 0 0.0301621 GO:0050764 regulation of phagocytosis 1 12 0 0.0301621 GO:0050766 positive regulation of phagocytosis 3 268 0.6 0.0304051 GO:0000151 ubiquitin ligase complex 11 2384 6 0.0307487 GO:0019538 protein metabolism 1 13 0 0.0326353 GO:0016197 endosome transport 1 13 0 0.0326353 GO:0019395 fatty acid oxidation 1 13 0 0.0326353 GO:0045121 lipid raft 1 1922 4.8 0.03435 u GO:0007166 cell surface receptor linked signal transduction 1 14 0 0.0351024 GO:0005924 cell-substrate adherens junction 1 14 0 0.0351024 GO:0045807 positive regulation of endocytosis 1 14 0 0.0351024 GO:0046777 autophosphorylation 20 5553 14.1 0.0351091 GO:0005622 intracellular 2 118 0.3 0.0362266 GO:0000278 mitotic cell cycle 2 119 0.3 0.0367878 GO:0007243 protein kinase cascade 1 15 0 0.0375634 GO:0004722 protein serine/threonine phosphatase activity 1 15 0 0.0375634 GO:0008286 insulin receptor signaling pathway 1 16 0 0.0400182 GO:0006289 nucleotide-excision repair 1 16 0 0.0400182 GO:0030055 cell-matrix junction 4 514 1.3 0.0406841 GO:0005856 cytoskeleton 1 17 0 0.042467 GO:0007032 endosome organization and biogenesis 3 307 0.7 0.0428031 GO:0004842 ubiquitin-protein ligase activity 5 771 1.9 0.0443283 GO:0016772 transferase activity, transferring phosphorus-containing groups 1 18 0 0.0449096 GO:0007015 actin filament organization 1 18 0 0.0449096 GO:0051050 positive regulation of transport 2 136 0.3 0.0468297 GO:0016779 nucleotidyltransferase activity 2 139 0.3 0.0486961 GO:0030695 GTPase regulator activity 3 326 0.8 0.0496385 GO:0016881 acid-D-amino acid ligase activity 1 20 0 0.0497769 GO:0006909 phagocytosis 2 141 0.3 0.0499554 GO:0000287 magnesium ion binding 1 21 0 0.0522014 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0 0.0522014 GO:0008287 protein serine/threonine phosphatase complex 7 1366 3.4 0.053879 GO:0017076 purine nucleotide binding 1 22 0 0.0546199 GO:0019901 protein kinase binding 7 1374 3.5 0.0553049 GO:0000166 nucleotide binding 3 345 0.8 0.0569803 GO:0004674 protein serine/threonine kinase activity 1 23 0 0.0570325 GO:0005905 coated pit 1 24 0 0.059439 GO:0007338 fertilization (sensu Animalia) 1 24 0 0.059439 GO:0009566 fertilization 1 24 0 0.059439 GO:0019900 kinase binding 4 586 1.4 0.060535 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 25 0 0.0618396 GO:0007249 I-kappaB kinase/NF-kappaB cascade 1 25 0 0.0618396 GO:0009617 response to bacteria 3 360 0.9 0.0631251 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 368 0.9 0.0665254 GO:0006512 ubiquitin cycle 1 27 0 0.0666229 GO:0008643 carbohydrate transport 7 4555 11.6 0.0670582 u GO:0016020 membrane 11 2707 6.8 0.0688384 GO:0005737 cytoplasm 1 28 0 0.0690057 GO:0004177 aminopeptidase activity 1 28 0 0.0690057 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1 32 0 0.0784777 GO:0005912 adherens junction 2 185 0.4 0.0804103 GO:0006396 RNA processing 1 34 0 0.0831785 GO:0008203 cholesterol metabolism 4 669 1.7 0.088841 GO:0006793 phosphorus metabolism 4 669 1.7 0.088841 GO:0006796 phosphate metabolism 1 37 0 0.090186 GO:0005319 lipid transporter activity 1 38 0 0.0925103 GO:0016125 sterol metabolism 2 203 0.5 0.0941884 GO:0000003 reproduction 2 203 0.5 0.0941884 GO:0019953 sexual reproduction 1 39 0 0.0948287 GO:0005543 phospholipid binding 8 1874 4.7 0.0954032 GO:0046872 metal ion binding 1 42 0.1 0.10175 GO:0030145 manganese ion binding 1 43 0.1 0.104045 GO:0006790 sulfur metabolism 2 222 0.5 0.109418 GO:0008092 cytoskeletal protein binding 3 460 1.1 0.111314 GO:0016874 ligase activity 1 48 0.1 0.115438 GO:0008235 metalloexopeptidase activity 1 48 0.1 0.115438 GO:0009897 external side of plasma membrane 1 48 0.1 0.115438 GO:0019897 extrinsic to plasma membrane 1 49 0.1 0.117699 GO:0019898 extrinsic to membrane 1 51 0.1 0.122205 GO:0005615 extracellular space 1 51 0.1 0.122205 GO:0005941 unlocalized 1 51 0.1 0.122205 GO:0016042 lipid catabolism 2 238 0.6 0.122721 GO:0016070 RNA metabolism 3 2359 6 0.126451 u GO:0004872 receptor activity 1 53 0.1 0.126689 GO:0006869 lipid transport 1 53 0.1 0.126689 GO:0019899 enzyme binding 2 244 0.6 0.12781 GO:0006996 organelle organization and biogenesis 1 54 0.1 0.128922 GO:0000375 RNA splicing, via transesterification reactions 1 54 0.1 0.128922 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 54 0.1 0.128922 GO:0000398 nuclear mRNA splicing, via spliceosome 1 54 0.1 0.128922 GO:0005777 peroxisome 1 54 0.1 0.128922 GO:0042579 microbody 1 55 0.1 0.13115 GO:0007160 cell-matrix adhesion 3 496 1.2 0.131381 GO:0004672 protein kinase activity 3 509 1.2 0.138932 GO:0006468 protein amino acid phosphorylation 4 797 2 0.142939 GO:0009056 catabolism 3 517 1.3 0.143653 GO:0006950 response to stress 10 2750 7 0.146912 GO:0008151 cell growth and/or maintenance 4 2728 6.9 0.148616 u GO:0007165 signal transduction 1 63 0.1 0.148776 GO:0030036 actin cytoskeleton organization and biogenesis 5 3170 8 0.150266 u GO:0007154 cell communication 1 65 0.1 0.153128 GO:0015293 symporter activity 1 67 0.1 0.157458 GO:0008380 RNA splicing 1 67 0.1 0.157458 GO:0030029 actin filament-based process 2 280 0.7 0.159324 GO:0005794 Golgi apparatus 4 2672 6.8 0.162517 u GO:0003676 nucleic acid binding 1 70 0.1 0.163913 GO:0006816 calcium ion transport 2 286 0.7 0.164716 GO:0007028 cytoplasm organization and biogenesis 7 1795 4.5 0.164968 GO:0016787 hydrolase activity 3 559 1.4 0.169303 GO:0016310 phosphorylation 1 73 0.1 0.170319 GO:0005875 microtubule associated complex 2 294 0.7 0.171958 GO:0030154 cell differentiation 1 74 0.1 0.172444 GO:0001501 skeletal development 1 74 0.1 0.172444 GO:0005516 calmodulin binding 1 75 0.1 0.174564 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 1 79 0.2 0.18299 GO:0007517 muscle development 3 590 1.5 0.189065 GO:0006508 proteolysis and peptidolysis 1 82 0.2 0.189255 GO:0008202 steroid metabolism 1 82 0.2 0.189255 GO:0009986 cell surface 1 83 0.2 0.191333 GO:0008238 exopeptidase activity 5 1221 3.1 0.196235 GO:0046914 transition metal ion binding 3 610 1.5 0.202136 GO:0030163 protein catabolism 3 613 1.5 0.204117 GO:0009057 macromolecule catabolism 5 2958 7.5 0.205252 u GO:0004871 signal transducer activity 2 1606 4 0.207137 u GO:0050791 regulation of physiological process 1 92 0.2 0.209801 GO:0006631 fatty acid metabolism 3 622 1.5 0.210087 GO:0008233 peptidase activity 2 337 0.8 0.211708 GO:0006118 electron transport 1 95 0.2 0.215866 GO:0007283 spermatogenesis 1 95 0.2 0.215866 GO:0048232 male gamete generation 3 632 1.6 0.216769 GO:0005739 mitochondrion 1 96 0.2 0.217877 GO:0005911 intercellular junction 3 634 1.6 0.218112 GO:0005886 plasma membrane 2 1564 3.9 0.222931 u GO:0019222 regulation of metabolism 1 102 0.2 0.229841 GO:0019866 inner membrane 2 358 0.9 0.231481 GO:0015031 protein transport 1 110 0.2 0.245516 GO:0006470 protein amino acid dephosphorylation 1 110 0.2 0.245516 GO:0015674 di-, tri-valent inorganic cation transport 1 111 0.2 0.247454 GO:0016327 apicolateral plasma membrane 1 112 0.2 0.249387 GO:0016311 dephosphorylation 2 384 0.9 0.256143 GO:0030234 enzyme regulator activity 1 118 0.3 0.260881 GO:0007167 enzyme linked receptor protein signaling pathway 2 390 0.9 0.261851 GO:0007155 cell adhesion 3 698 1.7 0.261943 GO:0009887 organogenesis 1 119 0.3 0.262781 GO:0030054 cell junction 10 3131 7.9 0.26288 GO:0050875 cellular physiological process 2 1458 3.7 0.266936 u GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 5 1372 3.4 0.268438 GO:0016740 transferase activity 2 1452 3.6 0.269609 u GO:0045449 regulation of transcription 1 125 0.3 0.274076 GO:0006281 DNA repair 1 128 0.3 0.27966 GO:0004721 phosphoprotein phosphatase activity 1 130 0.3 0.28336 GO:0015629 actin cytoskeleton 1 131 0.3 0.285203 GO:0003774 motor activity 2 1417 3.6 0.285594 u GO:0006351 transcription, DNA-dependent 2 1393 3.5 0.296947 u GO:0006355 regulation of transcription, DNA-dependent 1 138 0.3 0.297975 GO:0015630 microtubule cytoskeleton 2 433 1.1 0.302766 GO:0005102 receptor binding 4 1095 2.7 0.303703 GO:0008270 zinc ion binding 1 148 0.3 0.315837 GO:0008289 lipid binding 1 149 0.3 0.317598 GO:0006974 response to DNA damage stimulus 2 456 1.1 0.324554 GO:0004175 endopeptidase activity 1 157 0.4 0.331534 GO:0004252 serine-type endopeptidase activity 1 157 0.4 0.331534 GO:0009719 response to endogenous stimulus 1 158 0.4 0.333256 GO:0008237 metallopeptidase activity 1 159 0.4 0.334974 GO:0006066 alcohol metabolism 1 879 2.2 0.335163 u GO:0009605 response to external stimulus 1 160 0.4 0.336688 GO:0003779 actin binding 1 161 0.4 0.338397 GO:0015291 porter activity 1 162 0.4 0.340102 GO:0015290 electrochemical potential-driven transporter activity 1 166 0.4 0.34688 GO:0006457 protein folding 3 822 2 0.349572 GO:0009653 morphogenesis 1 169 0.4 0.35192 GO:0008236 serine-type peptidase activity 2 491 1.2 0.357411 GO:0007049 cell cycle 2 496 1.2 0.362066 GO:0050794 regulation of cellular process 1 178 0.4 0.366811 GO:0007276 gametogenesis 1 187 0.4 0.381369 GO:0016791 phosphoric monoester hydrolase activity 4 2048 5.2 0.386725 u GO:0050789 regulation of biological process 1 200 0.5 0.401825 GO:0005829 cytosol 3 1604 4 0.403848 u GO:0003677 DNA binding 1 204 0.5 0.407986 GO:0007010 cytoskeleton organization and biogenesis 1 211 0.5 0.418619 GO:0004518 nuclease activity 5 2374 6 0.422126 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 2 1147 2.9 0.431524 u GO:0005215 transporter activity 2 582 1.4 0.440044 GO:0016043 cell organization and biogenesis 1 723 1.8 0.443645 u GO:0005576 extracellular 2 594 1.5 0.450551 GO:0016788 hydrolase activity, acting on ester bonds 3 1516 3.8 0.450616 u GO:0006350 transcription 1 235 0.5 0.453685 GO:0009613 response to pest/pathogen/parasite 2 599 1.5 0.454899 GO:0016491 oxidoreductase activity 1 243 0.6 0.46491 GO:0042578 phosphoric ester hydrolase activity 6 2670 6.8 0.466351 u GO:0005634 nucleus 2 619 1.5 0.472103 GO:0008283 cell proliferation 1 259 0.6 0.486691 GO:0007399 neurogenesis 24 9173 23.3 0.489226 GO:0005623 cell 1 262 0.6 0.490678 GO:0019752 carboxylic acid metabolism 1 265 0.6 0.494634 GO:0006082 organic acid metabolism 2 660 1.6 0.506396 GO:0007242 intracellular signaling cascade 3 1058 2.6 0.512176 GO:0050896 response to stimulus 1 625 1.5 0.522795 u GO:0005198 structural molecule activity 1 620 1.5 0.527045 u GO:0006811 ion transport 1 297 0.7 0.535023 GO:0030001 metal ion transport 15 5831 14.8 0.544172 GO:0009987 cellular process 1 311 0.7 0.55169 GO:0005386 carrier activity 1 321 0.8 0.563237 GO:0046907 intracellular transport 1 578 1.4 0.563481 u GO:0009607 response to biotic stimulus 1 327 0.8 0.570026 GO:0005783 endoplasmic reticulum 1 375 0.9 0.620768 GO:0003723 RNA binding 1 505 1.2 0.629582 u GO:0006259 DNA metabolism 1 500 1.2 0.634217 u GO:0005509 calcium ion binding 1 399 1 0.729583 u GO:0006812 cation transport