# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 38 #b referenced loci : 36 #c annotated loci : 33 #d hyper-geometric : n 33 hgN 14129 #e k hgK Exp k p-value term description 14 2064 4.8 0.00010173 GO:0005515 protein binding 8 749 1.7 0.000255372 GO:0016301 kinase activity 26 7041 16.4 0.000609844 GO:0005488 binding 3 74 0.1 0.000672131 GO:0005516 calmodulin binding 3 102 0.2 0.0017029 GO:0045202 synapse 1 1 0 0.00233562 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00233562 GO:0008089 anterograde axon cargo transport 1 1 0 0.00233562 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00233562 GO:0030325 adrenal gland development 1 2 0 0.00466595 GO:0030517 negative regulation of axon extension 5 496 1.1 0.00550009 GO:0004672 protein kinase activity 3 157 0.3 0.00575183 GO:0012505 endomembrane system 2 49 0.1 0.00580881 GO:0005789 endoplasmic reticulum membrane 2 50 0.1 0.00604204 GO:0042175 nuclear envelope-endoplasmic reticulum network 5 509 1.1 0.00612926 GO:0006468 protein amino acid phosphorylation 5 514 1.2 0.00638434 GO:0005856 cytoskeleton 1 3 0 0.00699101 GO:0042147 retrograde transport, endosome to Golgi 4 345 0.8 0.00817547 GO:0004674 protein serine/threonine kinase activity 5 559 1.3 0.0090286 GO:0016310 phosphorylation 1 4 0 0.00931079 GO:0007435 salivary gland morphogenesis 1 4 0 0.00931079 GO:0008088 axon cargo transport 1 4 0 0.00931079 GO:0045767 regulation of anti-apoptosis 5 586 1.3 0.0109385 GO:0016773 phosphotransferase activity, alcohol group as acceptor 8 1366 3.1 0.01154 GO:0017076 purine nucleotide binding 1 5 0 0.0116253 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0116253 GO:0017137 Rab interactor activity 1 5 0 0.0116253 GO:0030516 regulation of axon extension 1 5 0 0.0116253 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0116253 GO:0030866 cortical actin cytoskeleton organization and biogenesis 8 1374 3.2 0.0119338 GO:0000166 nucleotide binding 2 73 0.1 0.0125362 GO:0005875 microtubule associated complex 1 6 0 0.0139346 GO:0001658 ureteric bud branching 1 6 0 0.0139346 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0139346 GO:0007431 salivary gland development 1 6 0 0.0139346 GO:0019894 kinesin binding 3 222 0.5 0.0147599 GO:0008092 cytoskeletal protein binding 5 669 1.5 0.0185241 GO:0006793 phosphorus metabolism 5 669 1.5 0.0185241 GO:0006796 phosphate metabolism 1 8 0 0.0185375 GO:0030659 cytoplasmic vesicle membrane 3 244 0.5 0.0189538 GO:0006996 organelle organization and biogenesis 2 92 0.2 0.0194262 GO:0005083 small GTPase regulatory/interacting protein activity 1 10 0 0.0231195 GO:0001763 branching morphogenesis 1 10 0 0.0231195 GO:0004685 calcium/calmodulin-dependent protein kinase activity 3 270 0.6 0.0246831 GO:0005578 extracellular matrix 1 11 0 0.0254028 GO:0001657 ureteric bud development 1 11 0 0.0254028 GO:0042472 inner ear morphogenesis 1 12 0 0.0276809 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0276809 GO:0042471 ear morphogenesis 4 500 1.1 0.0281618 GO:0005509 calcium ion binding 3 286 0.6 0.0286272 GO:0007028 cytoplasm organization and biogenesis 1 13 0 0.0299538 GO:0007548 sex differentiation 1 13 0 0.0299538 GO:0016197 endosome transport 1 13 0 0.0299538 GO:0016998 cell wall catabolism 1 13 0 0.0299538 GO:0042493 response to drug 2 119 0.2 0.0313371 GO:0007243 protein kinase cascade 2 119 0.2 0.0313371 GO:0009790 embryonic development 5 771 1.8 0.0318648 GO:0016772 transferase activity, transferring phosphorus-containing groups 1 14 0 0.0322215 GO:0004683 calmodulin regulated protein kinase activity 1 14 0 0.0322215 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0322215 GO:0012506 vesicle membrane 1 14 0 0.0322215 GO:0046777 autophosphorylation 2 122 0.2 0.0328019 GO:0007268 synaptic transmission 1 15 0 0.0344841 GO:0008207 C21-steroid hormone metabolism 6 1067 2.4 0.0348875 GO:0005524 ATP binding 2 128 0.2 0.0358109 GO:0019226 transmission of nerve impulse 2 128 0.2 0.0358109 GO:0050905 neuromuscular physiological process 6 1078 2.5 0.0364313 GO:0030554 adenyl nucleotide binding 1 16 0 0.0367416 GO:0005520 insulin-like growth factor binding 1 16 0 0.0367416 GO:0030176 integral to endoplasmic reticulum membrane 2 131 0.3 0.0373544 GO:0003774 motor activity 3 321 0.7 0.0383616 GO:0046907 intracellular transport 11 2707 6.3 0.0383739 GO:0005737 cytoplasm 1 17 0 0.0389939 GO:0007032 endosome organization and biogenesis 1 17 0 0.0389939 GO:0016323 basolateral plasma membrane 2 138 0.3 0.0410541 GO:0015630 microtubule cytoskeleton 1 18 0 0.0412412 GO:0001656 metanephros development 1 18 0 0.0412412 GO:0001822 kidney development 1 18 0 0.0412412 GO:0042446 hormone biosynthesis 2 139 0.3 0.0415936 GO:0030695 GTPase regulator activity 1 19 0 0.0434833 GO:0001655 urogenital system development 1 19 0 0.0434833 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0434833 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0434833 GO:0030286 dynein complex 4 582 1.3 0.0453236 GO:0016043 cell organization and biogenesis 1 21 0 0.0479524 GO:0000082 G1/S transition of mitotic cell cycle 2 151 0.3 0.0482748 GO:0007267 cell-cell signaling 1 1922 4.4 0.0495356 u GO:0007166 cell surface receptor linked signal transduction 2 160 0.3 0.0535263 GO:0003779 actin binding 1 24 0 0.0546181 GO:0003777 microtubule motor activity 1 24 0 0.0546181 GO:0006112 energy reserve metabolism 1 24 0 0.0546181 GO:0019933 cAMP-mediated signaling 2 162 0.3 0.0547201 GO:0004713 protein-tyrosine kinase activity 1 25 0 0.0568299 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0568299 GO:0008017 microtubule binding 3 384 0.8 0.0596152 GO:0030234 enzyme regulator activity 1 27 0 0.0612385 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.0612385 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 1 28 0 0.0634352 GO:0019935 cyclic-nucleotide-mediated signaling 4 660 1.5 0.0661354 GO:0007242 intracellular signaling cascade 2 183 0.4 0.0678095 GO:0050879 organismal movement 1 30 0 0.0678139 GO:0015631 tubulin binding 1 31 0 0.0699957 GO:0019838 growth factor binding 2 204 0.4 0.0818271 GO:0007010 cytoskeleton organization and biogenesis 1 37 0 0.0829833 GO:0007411 axon guidance 1 37 0 0.0829833 GO:0019932 second-messenger-mediated signaling 1 38 0 0.0851308 GO:0007018 microtubule-based movement 1 38 0 0.0851308 GO:0030705 cytoskeleton-dependent intracellular transport 4 723 1.6 0.0860863 GO:0005576 extracellular 1 39 0 0.0872733 GO:0042445 hormone metabolism 1 40 0 0.089411 GO:0000165 MAPKKK cascade 1 41 0 0.0915438 GO:0006694 steroid biosynthesis 1 44 0.1 0.0979133 GO:0007420 brain development 1 1597 3.7 0.0991444 u GO:0007186 G-protein coupled receptor protein signaling pathway 1 46 0.1 0.102136 GO:0009795 embryonic morphogenesis 1 47 0.1 0.104239 GO:0005262 calcium channel activity 1 47 0.1 0.104239 GO:0045211 postsynaptic membrane 6 1415 3.3 0.106437 GO:0007275 development 2 259 0.6 0.122138 GO:0007399 neurogenesis 4 822 1.9 0.122761 GO:0009653 morphogenesis 1 56 0.1 0.122961 GO:0016563 transcriptional activator activity 1 58 0.1 0.127069 GO:0001558 regulation of cell growth 1 58 0.1 0.127069 GO:0005730 nucleolus 1 58 0.1 0.127069 GO:0006916 anti-apoptosis 1 59 0.1 0.129117 GO:0005635 nuclear membrane 1 59 0.1 0.129117 GO:0008081 phosphoric diester hydrolase activity 5 1161 2.7 0.130098 GO:0006464 protein modification 1 62 0.1 0.13523 GO:0007417 central nervous system development 1 63 0.1 0.137259 GO:0007409 axonogenesis 1 63 0.1 0.137259 GO:0030036 actin cytoskeleton organization and biogenesis 1 66 0.1 0.143317 GO:0043066 negative regulation of apoptosis 1 66 0.1 0.143317 GO:0043069 negative regulation of programmed cell death 2 286 0.6 0.143429 GO:0005525 GTP binding 1 67 0.1 0.145328 GO:0030029 actin filament-based process 4 2958 6.9 0.149826 u GO:0004871 signal transducer activity 2 294 0.6 0.149887 GO:0019001 guanyl nucleotide binding 1 70 0.1 0.151331 GO:0006816 calcium ion transport 1 72 0.1 0.155311 GO:0016049 cell growth 1 75 0.1 0.161246 GO:0008361 regulation of cell size 6 1604 3.7 0.164925 GO:0003677 DNA binding 1 78 0.1 0.167141 GO:0040008 regulation of growth 2 319 0.7 0.170439 GO:0050877 neurophysiological process 1 82 0.1 0.174939 GO:0008202 steroid metabolism 3 2359 5.5 0.174984 u GO:0004872 receptor activity 1 83 0.1 0.176877 GO:0007156 homophilic cell adhesion 2 327 0.7 0.17712 GO:0005783 endoplasmic reticulum 1 84 0.1 0.178811 GO:0007017 microtubule-based process 16 5553 12.9 0.182741 GO:0005622 intracellular 1 91 0.2 0.192225 GO:0004867 serine-type endopeptidase inhibitor activity 7 2048 4.7 0.192622 GO:0050789 regulation of biological process 1 1221 2.8 0.208453 u GO:0046914 transition metal ion binding 5 1372 3.2 0.212389 GO:0016740 transferase activity 1 106 0.2 0.220258 GO:0016477 cell migration 5 1393 3.2 0.221443 GO:0006355 regulation of transcription, DNA-dependent 3 698 1.6 0.221824 GO:0009887 organogenesis 1 110 0.2 0.227573 GO:0015674 di-, tri-valent inorganic cation transport 2 390 0.9 0.230968 GO:0007155 cell adhesion 1 112 0.2 0.231205 GO:0006357 regulation of transcription from Pol II promoter 5 1417 3.3 0.231948 GO:0006351 transcription, DNA-dependent 1 113 0.2 0.233015 GO:0016337 cell-cell adhesion 1 113 0.2 0.233015 GO:0040007 growth 1 114 0.2 0.234821 GO:0015980 energy derivation by oxidation of organic compounds 1 1147 2.6 0.239201 u GO:0005215 transporter activity 1 118 0.2 0.242003 GO:0000278 mitotic cell cycle 1 120 0.2 0.24557 GO:0006091 energy pathways 5 1452 3.3 0.247548 GO:0045449 regulation of transcription 5 1458 3.4 0.250253 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 123 0.2 0.250889 GO:0042221 response to chemical substance 1 1095 2.5 0.262979 u GO:0008270 zinc ion binding 1 131 0.3 0.264896 GO:0004866 endopeptidase inhibitor activity 1 132 0.3 0.266629 GO:0030414 protease inhibitor activity 1 135 0.3 0.271805 GO:0000902 cellular morphogenesis 5 1516 3.5 0.276829 GO:0006350 transcription 1 139 0.3 0.27865 GO:0016023 cytoplasmic vesicle 1 140 0.3 0.280352 GO:0005244 voltage-gated ion channel activity 1 141 0.3 0.282049 GO:0008610 lipid biosynthesis 1 144 0.3 0.287119 GO:0050793 regulation of development 1 146 0.3 0.290479 GO:0006366 transcription from Pol II promoter 5 1564 3.6 0.299326 GO:0019222 regulation of metabolism 1 158 0.3 0.310322 GO:0006928 cell motility 5 1606 3.7 0.319308 GO:0050791 regulation of physiological process 1 165 0.3 0.321647 GO:0005624 membrane fraction 2 496 1.1 0.323371 GO:0050794 regulation of cellular process 1 172 0.4 0.332792 GO:0042981 regulation of apoptosis 1 174 0.4 0.335943 GO:0043067 regulation of programmed cell death 1 176 0.4 0.339081 GO:0004857 enzyme inhibitor activity 5 1656 3.8 0.343373 GO:0006810 transport 1 180 0.4 0.345312 GO:0000267 cell fraction 12 4537 10.5 0.360832 GO:0003824 catalytic activity 5 2728 6.3 0.365442 u GO:0007165 signal transduction 12 4555 10.6 0.366812 GO:0016020 membrane 1 200 0.4 0.375622 GO:0005829 cytosol 3 1795 4.1 0.381439 u GO:0016787 hydrolase activity 1 204 0.4 0.381519 GO:0007264 small GTPase mediated signal transduction 1 204 0.4 0.381519 GO:0009628 response to abiotic stimulus 1 879 2 0.382624 u GO:0009605 response to external stimulus 7 3552 8.2 0.386529 u GO:0016021 integral to membrane 1 872 2 0.387089 u GO:0009058 biosynthesis 1 212 0.4 0.39315 GO:0016192 vesicle-mediated transport 1 218 0.5 0.401735 GO:0006886 intracellular protein transport 1 221 0.5 0.405983 GO:0005261 cation channel activity 2 620 1.4 0.428228 GO:0006811 ion transport 7 2670 6.2 0.435177 GO:0005634 nucleus 1 243 0.5 0.436252 GO:0042578 phosphoric ester hydrolase activity 1 797 1.8 0.437271 u GO:0009056 catabolism 1 250 0.5 0.445566 GO:0016887 ATPase activity 5 1874 4.3 0.449486 GO:0046872 metal ion binding 8 3131 7.3 0.45324 GO:0050875 cellular physiological process 7 2750 6.4 0.468418 GO:0008151 cell growth and/or maintenance 8 3170 7.4 0.468576 GO:0007154 cell communication 1 280 0.6 0.483819 GO:0005794 Golgi apparatus 13 5837 13.6 0.485388 u GO:0008152 metabolism 1 724 1.6 0.490142 u GO:0009059 macromolecule biosynthesis 22 9173 21.4 0.49637 GO:0005623 cell 1 297 0.6 0.504346 GO:0030001 metal ion transport 5 2384 5.5 0.5083 u GO:0019538 protein metabolism 1 301 0.7 0.50906 GO:0005216 ion channel activity 14 5831 13.6 0.512619 GO:0009987 cellular process 5 2374 5.5 0.512688 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 309 0.7 0.518357 GO:0006915 apoptosis 1 313 0.7 0.522942 GO:0012501 programmed cell death 20 8414 19.6 0.525983 GO:0007582 physiological process 1 325 0.7 0.536442 GO:0015268 alpha-type channel activity 1 333 0.7 0.545236 GO:0015267 channel/pore class transporter activity 2 1058 2.4 0.546423 u GO:0050896 response to stimulus 2 776 1.8 0.547918 GO:0030528 transcription regulator activity 1 343 0.8 0.556001 GO:0008219 cell death 1 345 0.8 0.558125 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 346 0.8 0.559182 GO:0016265 death 1 634 1.4 0.560392 u GO:0005886 plasma membrane 1 348 0.8 0.561291 GO:0016817 hydrolase activity, acting on acid anhydrides 1 632 1.4 0.562011 u GO:0005739 mitochondrion 1 350 0.8 0.563389 GO:0006629 lipid metabolism 6 2672 6.2 0.56399 u GO:0003676 nucleic acid binding 1 625 1.4 0.567695 u GO:0005198 structural molecule activity 1 622 1.4 0.570139 u GO:0008233 peptidase activity 1 358 0.8 0.571687 GO:0015031 protein transport 1 619 1.4 0.572589 u GO:0008283 cell proliferation 1 599 1.3 0.589045 u GO:0016491 oxidoreductase activity 1 596 1.3 0.591532 u GO:0003700 transcription factor activity 1 594 1.3 0.593192 u GO:0016788 hydrolase activity, acting on ester bonds 1 399 0.9 0.611869 GO:0006812 cation transport 1 517 1.2 0.658465 u GO:0006950 response to stress 2 884 2 0.658689 u GO:0050874 organismal physiological process 1 491 1.1 0.680969 u GO:0007049 cell cycle 1 456 1 0.711469 u GO:0004175 endopeptidase activity