# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 44 #b referenced loci : 42 #c annotated loci : 38 #d hyper-geometric : n 38 hgN 14129 #e k hgK Exp k p-value term description 15 2064 5.5 0.000154579 GO:0005515 protein binding 8 749 2 0.000711276 GO:0016301 kinase activity 29 7041 18.9 0.000762717 GO:0005488 binding 3 74 0.1 0.00101992 GO:0005516 calmodulin binding 3 102 0.2 0.00256519 GO:0045202 synapse 1 1 0 0.0026895 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.0026895 GO:0008089 anterograde axon cargo transport 1 1 0 0.0026895 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.0026895 GO:0030325 adrenal gland development 1 2 0 0.00537196 GO:0030517 negative regulation of axon extension 2 49 0.1 0.00764932 GO:0005789 endoplasmic reticulum membrane 2 50 0.1 0.00795461 GO:0042175 nuclear envelope-endoplasmic reticulum network 1 3 0 0.0080474 GO:0042147 retrograde transport, endosome to Golgi 3 157 0.4 0.00854148 GO:0012505 endomembrane system 9 1366 3.6 0.00886527 GO:0017076 purine nucleotide binding 9 1374 3.6 0.00920017 GO:0000166 nucleotide binding 5 496 1.3 0.0100814 GO:0004672 protein kinase activity 1 4 0 0.0107158 GO:0007435 salivary gland morphogenesis 1 4 0 0.0107158 GO:0008088 axon cargo transport 1 4 0 0.0107158 GO:0045767 regulation of anti-apoptosis 5 509 1.3 0.0111929 GO:0006468 protein amino acid phosphorylation 5 514 1.3 0.0116421 GO:0005856 cytoskeleton 1 5 0 0.0133773 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0133773 GO:0017137 Rab interactor activity 1 5 0 0.0133773 GO:0030516 regulation of axon extension 1 5 0 0.0133773 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0133773 GO:0030866 cortical actin cytoskeleton organization and biogenesis 4 345 0.9 0.0134109 GO:0004674 protein serine/threonine kinase activity 1 6 0 0.0160317 GO:0001658 ureteric bud branching 1 6 0 0.0160317 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0160317 GO:0007431 salivary gland development 1 6 0 0.0160317 GO:0019894 kinesin binding 5 559 1.5 0.0162542 GO:0016310 phosphorylation 2 73 0.1 0.0164168 GO:0005875 microtubule associated complex 5 586 1.5 0.0195421 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 8 0 0.0213198 GO:0030659 cytoplasmic vesicle membrane 3 222 0.5 0.0215563 GO:0008092 cytoskeletal protein binding 7 1067 2.8 0.0219737 GO:0005524 ATP binding 7 1078 2.8 0.0231078 GO:0030554 adenyl nucleotide binding 2 92 0.2 0.0253289 GO:0005083 small GTPase regulatory/interacting protein activity 1 10 0 0.0265802 GO:0001763 branching morphogenesis 1 10 0 0.0265802 GO:0004685 calcium/calmodulin-dependent protein kinase activity 1 1922 5.1 0.0268335 u GO:0007166 cell surface receptor linked signal transduction 3 244 0.6 0.027527 GO:0006996 organelle organization and biogenesis 1 11 0 0.0292001 GO:0001657 ureteric bud development 1 11 0 0.0292001 GO:0042472 inner ear morphogenesis 1 12 0 0.0318131 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0318131 GO:0042471 ear morphogenesis 5 669 1.7 0.0323278 GO:0006793 phosphorus metabolism 5 669 1.7 0.0323278 GO:0006796 phosphate metabolism 1 13 0 0.0344193 GO:0007548 sex differentiation 1 13 0 0.0344193 GO:0016197 endosome transport 1 13 0 0.0344193 GO:0016998 cell wall catabolism 1 13 0 0.0344193 GO:0042493 response to drug 3 270 0.7 0.0356133 GO:0005578 extracellular matrix 1 14 0 0.0370186 GO:0004683 calmodulin regulated protein kinase activity 1 14 0 0.0370186 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0370186 GO:0012506 vesicle membrane 1 14 0 0.0370186 GO:0046777 autophosphorylation 1 15 0 0.0396111 GO:0008207 C21-steroid hormone metabolism 2 119 0.3 0.0406087 GO:0007243 protein kinase cascade 2 119 0.3 0.0406087 GO:0009790 embryonic development 3 286 0.7 0.0411382 GO:0007028 cytoplasm organization and biogenesis 1 16 0 0.0421968 GO:0005520 insulin-like growth factor binding 1 16 0 0.0421968 GO:0030176 integral to endoplasmic reticulum membrane 2 122 0.3 0.0424779 GO:0007268 synaptic transmission 4 500 1.3 0.0443054 GO:0005509 calcium ion binding 1 17 0 0.0447757 GO:0007032 endosome organization and biogenesis 1 17 0 0.0447757 GO:0016323 basolateral plasma membrane 2 128 0.3 0.0463118 GO:0019226 transmission of nerve impulse 2 128 0.3 0.0463118 GO:0050905 neuromuscular physiological process 12 2707 7.2 0.0467307 GO:0005737 cytoplasm 1 18 0 0.0473479 GO:0001656 metanephros development 1 18 0 0.0473479 GO:0001822 kidney development 1 18 0 0.0473479 GO:0042446 hormone biosynthesis 2 131 0.3 0.0482752 GO:0003774 motor activity 1 19 0 0.0499133 GO:0001655 urogenital system development 1 19 0 0.0499133 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0499133 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0499133 GO:0030286 dynein complex 2 138 0.3 0.052973 GO:0015630 microtubule cytoskeleton 2 139 0.3 0.0536571 GO:0030695 GTPase regulator activity 5 771 2 0.0540481 GO:0016772 transferase activity, transferring phosphorus-containing groups 3 321 0.8 0.0546472 GO:0046907 intracellular transport 1 21 0 0.055024 GO:0000082 G1/S transition of mitotic cell cycle 1 1597 4.2 0.061016 u GO:0007186 G-protein coupled receptor protein signaling pathway 2 151 0.4 0.0621088 GO:0007267 cell-cell signaling 1 24 0 0.0626399 GO:0003777 microtubule motor activity 1 24 0 0.0626399 GO:0006112 energy reserve metabolism 1 24 0 0.0626399 GO:0019933 cAMP-mediated signaling 1 25 0 0.0651652 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0651652 GO:0008017 microtubule binding 2 160 0.4 0.0687271 GO:0003779 actin binding 4 582 1.5 0.0697763 GO:0016043 cell organization and biogenesis 1 27 0 0.070196 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.070196 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 2 162 0.4 0.0702286 GO:0004713 protein-tyrosine kinase activity 1 28 0 0.0727015 GO:0019935 cyclic-nucleotide-mediated signaling 4 2958 7.9 0.0767423 u GO:0004871 signal transducer activity 1 30 0 0.0776928 GO:0015631 tubulin binding 1 31 0 0.0801787 GO:0019838 growth factor binding 3 384 1 0.0836149 GO:0030234 enzyme regulator activity 2 183 0.4 0.0866237 GO:0050879 organismal movement 6 1161 3.1 0.0876108 GO:0006464 protein modification 1 37 0 0.0949572 GO:0007411 axon guidance 1 37 0 0.0949572 GO:0019932 second-messenger-mediated signaling 1 38 0.1 0.0973977 GO:0007018 microtubule-based movement 1 38 0.1 0.0973977 GO:0030705 cytoskeleton-dependent intracellular transport 4 660 1.7 0.0997697 GO:0007242 intracellular signaling cascade 1 39 0.1 0.0998318 GO:0042445 hormone metabolism 3 2359 6.3 0.100971 u GO:0004872 receptor activity 1 40 0.1 0.10226 GO:0000165 MAPKKK cascade 2 204 0.5 0.10405 GO:0007010 cytoskeleton organization and biogenesis 1 41 0.1 0.104681 GO:0006694 steroid biosynthesis 1 44 0.1 0.111907 GO:0007420 brain development 1 46 0.1 0.116692 GO:0009795 embryonic morphogenesis 19 5553 14.9 0.118553 GO:0005622 intracellular 1 47 0.1 0.119076 GO:0005262 calcium channel activity 1 47 0.1 0.119076 GO:0045211 postsynaptic membrane 4 723 1.9 0.127785 GO:0005576 extracellular 1 56 0.1 0.140247 GO:0016563 transcriptional activator activity 1 58 0.1 0.144884 GO:0001558 regulation of cell growth 1 58 0.1 0.144884 GO:0005730 nucleolus 1 58 0.1 0.144884 GO:0006916 anti-apoptosis 1 59 0.1 0.147193 GO:0005635 nuclear membrane 1 59 0.1 0.147193 GO:0008081 phosphoric diester hydrolase activity 2 259 0.6 0.153473 GO:0007399 neurogenesis 1 62 0.1 0.154085 GO:0007417 central nervous system development 1 63 0.1 0.15637 GO:0007409 axonogenesis 1 63 0.1 0.15637 GO:0030036 actin cytoskeleton organization and biogenesis 1 66 0.1 0.163189 GO:0043066 negative regulation of apoptosis 1 66 0.1 0.163189 GO:0043069 negative regulation of programmed cell death 1 67 0.1 0.16545 GO:0030029 actin filament-based process 1 70 0.1 0.172198 GO:0006816 calcium ion transport 1 1147 3 0.174188 u GO:0005215 transporter activity 6 1415 3.8 0.175332 GO:0007275 development 1 72 0.1 0.176667 GO:0016049 cell growth 4 822 2.2 0.177734 GO:0009653 morphogenesis 2 286 0.7 0.179198 GO:0005525 GTP binding 1 75 0.2 0.183327 GO:0008361 regulation of cell size 2 294 0.7 0.186952 GO:0019001 guanyl nucleotide binding 1 78 0.2 0.189934 GO:0040008 regulation of growth 1 82 0.2 0.198662 GO:0008202 steroid metabolism 1 83 0.2 0.20083 GO:0007156 homophilic cell adhesion 1 84 0.2 0.202992 GO:0007017 microtubule-based process 2 319 0.8 0.21148 GO:0050877 neurophysiological process 1 91 0.2 0.217968 GO:0004867 serine-type endopeptidase inhibitor activity 2 327 0.8 0.219405 GO:0005783 endoplasmic reticulum 7 3552 9.5 0.225069 u GO:0016021 integral to membrane 5 2728 7.3 0.230609 u GO:0007165 signal transduction 1 106 0.2 0.249142 GO:0016477 cell migration 1 110 0.2 0.257249 GO:0015674 di-, tri-valent inorganic cation transport 6 1604 4.3 0.258154 GO:0003677 DNA binding 1 112 0.3 0.26127 GO:0006357 regulation of transcription from Pol II promoter 1 113 0.3 0.263273 GO:0016337 cell-cell adhesion 1 113 0.3 0.263273 GO:0040007 growth 1 114 0.3 0.26527 GO:0015980 energy derivation by oxidation of organic compounds 3 1795 4.8 0.271096 u GO:0016787 hydrolase activity 1 118 0.3 0.273207 GO:0000278 mitotic cell cycle 1 120 0.3 0.277144 GO:0006091 energy pathways 2 390 1 0.282467 GO:0007155 cell adhesion 1 123 0.3 0.283011 GO:0042221 response to chemical substance 3 698 1.8 0.289173 GO:0009887 organogenesis 1 131 0.3 0.29843 GO:0004866 endopeptidase inhibitor activity 1 132 0.3 0.300335 GO:0030414 protease inhibitor activity 1 135 0.3 0.306018 GO:0000902 cellular morphogenesis 1 879 2.3 0.306237 u GO:0009605 response to external stimulus 5 1372 3.6 0.307424 GO:0016740 transferase activity 7 2048 5.5 0.308446 GO:0050789 regulation of biological process 1 872 2.3 0.310553 u GO:0009058 biosynthesis 1 139 0.3 0.313526 GO:0016023 cytoplasmic vesicle 1 140 0.3 0.315391 GO:0005244 voltage-gated ion channel activity 1 141 0.3 0.317251 GO:0008610 lipid biosynthesis 5 1393 3.7 0.318871 GO:0006355 regulation of transcription, DNA-dependent 1 144 0.3 0.3228 GO:0050793 regulation of development 1 146 0.3 0.326475 GO:0006366 transcription from Pol II promoter 5 1417 3.8 0.332035 GO:0006351 transcription, DNA-dependent 1 158 0.4 0.348123 GO:0006928 cell motility 14 5837 15.6 0.349563 u GO:0008152 metabolism 2 1221 3.2 0.350595 u GO:0046914 transition metal ion binding 21 8414 22.6 0.351149 u GO:0007582 physiological process 5 1452 3.9 0.351359 GO:0045449 regulation of transcription 14 5831 15.6 0.351541 u GO:0009987 cellular process 5 1458 3.9 0.354683 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 797 2.1 0.359834 u GO:0009056 catabolism 1 165 0.4 0.360436 GO:0005624 membrane fraction 5 2374 6.3 0.366506 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 172 0.4 0.372523 GO:0042981 regulation of apoptosis 1 174 0.4 0.375935 GO:0043067 regulation of programmed cell death 1 176 0.4 0.379329 GO:0004857 enzyme inhibitor activity 1 180 0.4 0.386064 GO:0000267 cell fraction 5 1516 4 0.386926 GO:0006350 transcription 2 496 1.3 0.387401 GO:0050794 regulation of cellular process 6 1874 5 0.391282 GO:0046872 metal ion binding 6 2672 7.1 0.40383 u GO:0003676 nucleic acid binding 1 724 1.9 0.413219 u GO:0009059 macromolecule biosynthesis 5 1564 4.2 0.413651 GO:0019222 regulation of metabolism 1 200 0.5 0.418683 GO:0005829 cytosol 1 204 0.5 0.425002 GO:0007264 small GTPase mediated signal transduction 1 204 0.5 0.425002 GO:0009628 response to abiotic stimulus 2 1095 2.9 0.42663 u GO:0008270 zinc ion binding 8 2670 7.1 0.430669 GO:0005634 nucleus 5 1606 4.3 0.436967 GO:0050791 regulation of physiological process 1 212 0.5 0.437439 GO:0016192 vesicle-mediated transport 1 218 0.5 0.446594 GO:0006886 intracellular protein transport 13 4537 12.2 0.450661 GO:0003824 catalytic activity 2 1058 2.8 0.45067 u GO:0050896 response to stimulus 1 221 0.5 0.451117 GO:0005261 cation channel activity 5 1656 4.4 0.464534 GO:0006810 transport 1 243 0.6 0.483204 GO:0042578 phosphoric ester hydrolase activity 1 634 1.7 0.486349 u GO:0005886 plasma membrane 1 250 0.6 0.493025 GO:0016887 ATPase activity 1 625 1.6 0.494091 u GO:0005198 structural molecule activity 1 622 1.6 0.496688 u GO:0008233 peptidase activity 1 619 1.6 0.499294 u GO:0008283 cell proliferation 2 620 1.6 0.501576 GO:0006811 ion transport 8 3170 8.5 0.510452 u GO:0007154 cell communication 2 632 1.6 0.511937 GO:0005739 mitochondrion 1 264 0.7 0.512125 GO:0016567 protein ubiquitination 1 599 1.6 0.516872 u GO:0016491 oxidoreductase activity 1 268 0.7 0.517452 GO:0000151 ubiquitin ligase complex 1 596 1.6 0.51954 u GO:0003700 transcription factor activity 1 594 1.5 0.521322 u GO:0016788 hydrolase activity, acting on ester bonds 8 3131 8.4 0.526919 u GO:0050875 cellular physiological process 25 9173 24.6 0.529892 GO:0005623 cell 1 280 0.7 0.533096 GO:0005794 Golgi apparatus 7 2750 7.3 0.53374 u GO:0008151 cell growth and/or maintenance 6 2384 6.4 0.534522 u GO:0019538 protein metabolism 12 4555 12.2 0.542605 u GO:0016020 membrane 1 297 0.7 0.554415 GO:0030001 metal ion transport 1 301 0.8 0.559292 GO:0005216 ion channel activity 1 307 0.8 0.56651 GO:0004842 ubiquitin-protein ligase activity 1 309 0.8 0.568891 GO:0006915 apoptosis 2 884 2.3 0.572309 u GO:0050874 organismal physiological process 1 313 0.8 0.573613 GO:0012501 programmed cell death 1 325 0.8 0.587481 GO:0015268 alpha-type channel activity 1 326 0.8 0.588616 GO:0016881 acid-D-amino acid ligase activity 1 517 1.3 0.592448 u GO:0006950 response to stress 1 333 0.8 0.596481 GO:0015267 channel/pore class transporter activity 1 343 0.9 0.607462 GO:0008219 cell death 1 345 0.9 0.609623 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 346 0.9 0.610699 GO:0016265 death 1 348 0.9 0.612843 GO:0016817 hydrolase activity, acting on acid anhydrides 1 350 0.9 0.614975 GO:0006629 lipid metabolism 1 491 1.3 0.617437 u GO:0007049 cell cycle 1 358 0.9 0.623391 GO:0015031 protein transport 1 360 0.9 0.625466 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1 368 0.9 0.633658 GO:0006512 ubiquitin cycle 1 460 1.2 0.647742 u GO:0016874 ligase activity 1 456 1.2 0.651687 u GO:0004175 endopeptidase activity 2 776 2 0.652511 u GO:0030528 transcription regulator activity 1 399 1 0.7085 u GO:0006812 cation transport