# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 51 #b referenced loci : 49 #c annotated loci : 43 #d hyper-geometric : n 43 hgN 14129 #e k hgK Exp k p-value term description 16 2064 6.2 0.000212389 GO:0005515 protein binding 3 74 0.2 0.00146434 GO:0005516 calmodulin binding 8 749 2.2 0.00166922 GO:0016301 kinase activity 31 7041 21.4 0.00249369 GO:0005488 binding 1 1 0 0.00304339 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00304339 GO:0008089 anterograde axon cargo transport 1 1 0 0.00304339 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00304339 GO:0030325 adrenal gland development 3 102 0.3 0.00365611 GO:0045202 synapse 6 514 1.5 0.00437219 GO:0005856 cytoskeleton 4 222 0.6 0.00453117 GO:0008092 cytoskeletal protein binding 1 2 0 0.00607772 GO:0030517 negative regulation of axon extension 1 2 0 0.00607772 GO:0045646 regulation of erythrocyte differentiation 1 2 0 0.00607772 GO:0045648 positive regulation of erythrocyte differentiation 10 1366 4.1 0.00680155 GO:0017076 purine nucleotide binding 10 1374 4.1 0.00708327 GO:0000166 nucleotide binding 1 3 0 0.00910304 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1 3 0 0.00910304 GO:0004828 serine-tRNA ligase activity 1 3 0 0.00910304 GO:0006434 seryl-tRNA aminoacylation 1 3 0 0.00910304 GO:0042147 retrograde transport, endosome to Golgi 2 49 0.1 0.00971797 GO:0005789 endoplasmic reticulum membrane 2 50 0.1 0.0101035 GO:0042175 nuclear envelope-endoplasmic reticulum network 3 157 0.4 0.0120022 GO:0012505 endomembrane system 1 4 0 0.0121194 GO:0007435 salivary gland morphogenesis 1 4 0 0.0121194 GO:0008088 axon cargo transport 1 4 0 0.0121194 GO:0045639 positive regulation of myeloid blood cell differentiation 1 4 0 0.0121194 GO:0045767 regulation of anti-apoptosis 8 1067 3.2 0.0139393 GO:0005524 ATP binding 1 1922 5.8 0.014347 u GO:0007166 cell surface receptor linked signal transduction 8 1078 3.2 0.014762 GO:0030554 adenyl nucleotide binding 6 669 2 0.0150871 GO:0006793 phosphorus metabolism 6 669 2 0.0150871 GO:0006796 phosphate metabolism 1 5 0 0.0151267 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0151267 GO:0017137 Rab interactor activity 1 5 0 0.0151267 GO:0030516 regulation of axon extension 1 5 0 0.0151267 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0151267 GO:0030866 cortical actin cytoskeleton organization and biogenesis 5 496 1.5 0.0167682 GO:0004672 protein kinase activity 1 6 0 0.0181251 GO:0001658 ureteric bud branching 1 6 0 0.0181251 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0181251 GO:0007431 salivary gland development 1 6 0 0.0181251 GO:0019894 kinesin binding 5 509 1.5 0.0185488 GO:0006468 protein amino acid phosphorylation 4 345 1 0.0203981 GO:0004674 protein serine/threonine kinase activity 2 73 0.2 0.0207413 GO:0005875 microtubule associated complex 1 8 0 0.0240952 GO:0030218 erythrocyte differentiation 1 8 0 0.0240952 GO:0030659 cytoplasmic vesicle membrane 14 2707 8.2 0.0256928 GO:0005737 cytoplasm 5 559 1.7 0.0265601 GO:0016310 phosphorylation 1 10 0 0.0300299 GO:0001763 branching morphogenesis 1 10 0 0.0300299 GO:0004685 calcium/calmodulin-dependent protein kinase activity 5 586 1.7 0.0316925 GO:0016773 phosphotransferase activity, alcohol group as acceptor 2 92 0.2 0.0318624 GO:0005083 small GTPase regulatory/interacting protein activity 1 11 0 0.0329839 GO:0001657 ureteric bud development 1 11 0 0.0329839 GO:0042472 inner ear morphogenesis 1 12 0 0.0359292 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0359292 GO:0042471 ear morphogenesis 1 1597 4.8 0.0370959 u GO:0007186 G-protein coupled receptor protein signaling pathway 3 244 0.7 0.0378356 GO:0006996 organelle organization and biogenesis 1 13 0 0.0388658 GO:0007548 sex differentiation 1 13 0 0.0388658 GO:0016197 endosome transport 1 13 0 0.0388658 GO:0016998 cell wall catabolism 1 13 0 0.0388658 GO:0042493 response to drug 1 14 0 0.0417936 GO:0004683 calmodulin regulated protein kinase activity 1 14 0 0.0417936 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0417936 GO:0012506 vesicle membrane 1 14 0 0.0417936 GO:0046777 autophosphorylation 1 15 0 0.0447127 GO:0008207 C21-steroid hormone metabolism 1 15 0 0.0447127 GO:0045637 regulation of myeloid blood cell differentiation 1 16 0 0.0476231 GO:0005520 insulin-like growth factor binding 1 16 0 0.0476231 GO:0030176 integral to endoplasmic reticulum membrane 3 270 0.8 0.0486333 GO:0005578 extracellular matrix 1 17 0 0.0505248 GO:0007032 endosome organization and biogenesis 1 17 0 0.0505248 GO:0016323 basolateral plasma membrane 2 119 0.3 0.0507727 GO:0007243 protein kinase cascade 2 119 0.3 0.0507727 GO:0009790 embryonic development 2 122 0.3 0.053074 GO:0007268 synaptic transmission 1 18 0 0.0534179 GO:0001656 metanephros development 1 18 0 0.0534179 GO:0001822 kidney development 1 18 0 0.0534179 GO:0042446 hormone biosynthesis 3 286 0.8 0.0559556 GO:0007028 cytoplasm organization and biogenesis 1 19 0 0.0563024 GO:0001655 urogenital system development 1 19 0 0.0563024 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0 0.0563024 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0 0.0563024 GO:0030286 dynein complex 2 128 0.3 0.0577865 GO:0019226 transmission of nerve impulse 2 128 0.3 0.0577865 GO:0050905 neuromuscular physiological process 1 20 0 0.0591783 GO:0045597 positive regulation of cell differentiation 7 1161 3.5 0.059276 GO:0006464 protein modification 2 131 0.3 0.060196 GO:0003774 motor activity 1 21 0 0.0620456 GO:0000082 G1/S transition of mitotic cell cycle 1 21 0 0.0620456 GO:0043087 regulation of GTPase activity 4 500 1.5 0.0646686 GO:0005509 calcium ion binding 2 138 0.4 0.0659508 GO:0015630 microtubule cytoskeleton 2 139 0.4 0.0667876 GO:0030695 GTPase regulator activity 1 24 0 0.0705965 GO:0003777 microtubule motor activity 1 24 0 0.0705965 GO:0006112 energy reserve metabolism 1 24 0 0.0705965 GO:0019933 cAMP-mediated signaling 2 144 0.4 0.0710251 GO:0050793 regulation of development 1 25 0 0.0734299 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0 0.0734299 GO:0008017 microtubule binding 3 321 0.9 0.0736925 GO:0046907 intracellular transport 3 327 0.9 0.0769605 GO:0005783 endoplasmic reticulum 2 151 0.4 0.0771018 GO:0007267 cell-cell signaling 1 27 0 0.0790713 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0 0.0790713 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 1 28 0 0.0818794 GO:0019935 cyclic-nucleotide-mediated signaling 5 771 2.3 0.0833015 GO:0016772 transferase activity, transferring phosphorus-containing groups 2 160 0.4 0.0851483 GO:0003779 actin binding 2 162 0.4 0.0869704 GO:0004713 protein-tyrosine kinase activity 1 30 0 0.0874705 GO:0015631 tubulin binding 5 2958 9 0.0884948 u GO:0004871 signal transducer activity 1 31 0 0.0902536 GO:0019838 growth factor binding 4 582 1.7 0.0997055 GO:0016043 cell organization and biogenesis 5 822 2.5 0.102638 GO:0009653 morphogenesis 1 37 0.1 0.106779 GO:0007411 axon guidance 1 37 0.1 0.106779 GO:0019932 second-messenger-mediated signaling 2 183 0.5 0.106782 GO:0050879 organismal movement 1 38 0.1 0.109504 GO:0007018 microtubule-based movement 1 38 0.1 0.109504 GO:0030705 cytoskeleton-dependent intracellular transport 3 384 1.1 0.111047 GO:0030234 enzyme regulator activity 1 39 0.1 0.112222 GO:0006418 tRNA aminoacylation for protein translation 1 39 0.1 0.112222 GO:0030099 myeloid blood cell differentiation 1 39 0.1 0.112222 GO:0042445 hormone metabolism 1 39 0.1 0.112222 GO:0043038 amino acid activation 1 39 0.1 0.112222 GO:0043039 tRNA aminoacylation 1 40 0.1 0.114931 GO:0000165 MAPKKK cascade 1 41 0.1 0.117632 GO:0004812 tRNA ligase activity 1 41 0.1 0.117632 GO:0006694 steroid biosynthesis 1 41 0.1 0.117632 GO:0008452 RNA ligase activity 1 41 0.1 0.117632 GO:0016875 ligase activity, forming carbon-oxygen bonds 1 41 0.1 0.117632 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 1 42 0.1 0.120326 GO:0006400 tRNA modification 1 1147 3.4 0.125523 u GO:0005215 transporter activity 1 44 0.1 0.125688 GO:0007420 brain development 2 204 0.6 0.12768 GO:0007010 cytoskeleton organization and biogenesis 21 5553 16.8 0.130592 GO:0005622 intracellular 1 46 0.1 0.131018 GO:0009795 embryonic morphogenesis 4 2359 7.1 0.133165 u GO:0004872 receptor activity 1 47 0.1 0.133672 GO:0005262 calcium channel activity 1 47 0.1 0.133672 GO:0016886 ligase activity, forming phosphoric ester bonds 1 47 0.1 0.133672 GO:0045211 postsynaptic membrane 7 1415 4.3 0.133697 GO:0007275 development 5 2728 8.3 0.136787 u GO:0007165 signal transduction 1 49 0.1 0.138955 GO:0009451 RNA modification 4 660 2 0.139768 GO:0007242 intracellular signaling cascade 1 50 0.1 0.141584 GO:0050790 regulation of enzyme activity 1 55 0.1 0.154615 GO:0004725 protein tyrosine phosphatase activity 1 56 0.1 0.157198 GO:0016563 transcriptional activator activity 4 698 2.1 0.161364 GO:0009887 organogenesis 1 58 0.1 0.162341 GO:0001558 regulation of cell growth 1 58 0.1 0.162341 GO:0005730 nucleolus 1 58 0.1 0.162341 GO:0006916 anti-apoptosis 1 59 0.1 0.1649 GO:0005635 nuclear membrane 1 59 0.1 0.1649 GO:0008081 phosphoric diester hydrolase activity 2 243 0.7 0.168697 GO:0042578 phosphoric ester hydrolase activity 1 62 0.1 0.172534 GO:0007417 central nervous system development 1 63 0.1 0.175064 GO:0007409 axonogenesis 1 63 0.1 0.175064 GO:0030036 actin cytoskeleton organization and biogenesis 4 723 2.2 0.176225 GO:0005576 extracellular 1 65 0.1 0.1801 GO:0006399 tRNA metabolism 1 66 0.2 0.182606 GO:0043066 negative regulation of apoptosis 1 66 0.2 0.182606 GO:0043069 negative regulation of programmed cell death 1 67 0.2 0.185106 GO:0030029 actin filament-based process 2 259 0.7 0.186141 GO:0007399 neurogenesis 3 496 1.5 0.191081 GO:0050794 regulation of cellular process 1 70 0.2 0.192559 GO:0006816 calcium ion transport 1 70 0.2 0.192559 GO:0045595 regulation of cell differentiation 1 72 0.2 0.197491 GO:0016049 cell growth 1 75 0.2 0.204833 GO:0008361 regulation of cell size 8 3552 10.8 0.211012 u GO:0016021 integral to membrane 1 78 0.2 0.21211 GO:0040008 regulation of growth 2 286 0.8 0.216125 GO:0005525 GTP binding 1 82 0.2 0.221712 GO:0008202 steroid metabolism 1 83 0.2 0.224094 GO:0007156 homophilic cell adhesion 2 294 0.8 0.225106 GO:0019001 guanyl nucleotide binding 1 84 0.2 0.22647 GO:0007017 microtubule-based process 1 879 2.6 0.242897 u GO:0009605 response to external stimulus 1 91 0.2 0.242899 GO:0004867 serine-type endopeptidase inhibitor activity 15 5831 17.7 0.244683 u GO:0009987 cellular process 2 319 0.9 0.253346 GO:0050877 neurophysiological process 23 8414 25.6 0.254415 u GO:0007582 physiological process 2 1221 3.7 0.269332 u GO:0046914 transition metal ion binding 6 2672 8.1 0.270625 u GO:0003676 nucleic acid binding 1 106 0.3 0.276966 GO:0016477 cell migration 1 107 0.3 0.279183 GO:0030097 hemopoiesis 8 2048 6.2 0.279237 GO:0050789 regulation of biological process 16 4537 13.8 0.285569 GO:0003824 catalytic activity 1 110 0.3 0.285795 GO:0006470 protein amino acid dephosphorylation 1 110 0.3 0.285795 GO:0015674 di-, tri-valent inorganic cation transport 1 112 0.3 0.29017 GO:0006357 regulation of transcription from Pol II promoter 1 112 0.3 0.29017 GO:0016311 dephosphorylation 1 113 0.3 0.292347 GO:0016337 cell-cell adhesion 1 113 0.3 0.292347 GO:0040007 growth 1 797 2.4 0.293609 u GO:0009056 catabolism 1 114 0.3 0.294518 GO:0015980 energy derivation by oxidation of organic compounds 1 118 0.3 0.303137 GO:0000278 mitotic cell cycle 1 120 0.3 0.307408 GO:0006091 energy pathways 1 123 0.3 0.313767 GO:0042221 response to chemical substance 1 127 0.3 0.322156 GO:0043037 translation 1 128 0.3 0.324238 GO:0004721 phosphoprotein phosphatase activity 1 131 0.3 0.330445 GO:0004866 endopeptidase inhibitor activity 1 132 0.4 0.332502 GO:0006520 amino acid metabolism 1 132 0.4 0.332502 GO:0030414 protease inhibitor activity 2 390 1.1 0.333663 GO:0007155 cell adhesion 1 135 0.4 0.338636 GO:0000902 cellular morphogenesis 2 1095 3.3 0.341885 u GO:0008270 zinc ion binding 1 139 0.4 0.346728 GO:0016023 cytoplasmic vesicle 8 3170 9.6 0.347888 u GO:0007154 cell communication 1 140 0.4 0.348736 GO:0005244 voltage-gated ion channel activity 16 5837 17.7 0.350564 u GO:0008152 metabolism 1 141 0.4 0.350738 GO:0008610 lipid biosynthesis 1 146 0.4 0.360657 GO:0006366 transcription from Pol II promoter 6 1604 4.8 0.3617 GO:0003677 DNA binding 8 3131 9.5 0.36402 u GO:0050875 cellular physiological process 2 1058 3.2 0.365543 u GO:0050896 response to stimulus 7 2750 8.3 0.382482 u GO:0008151 cell growth and/or maintenance 1 158 0.4 0.383864 GO:0006928 cell motility 1 165 0.5 0.39702 GO:0005624 membrane fraction 6 2374 7.2 0.400069 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 167 0.5 0.400728 GO:0006519 amino acid and derivative metabolism 5 1372 4.1 0.407064 GO:0016740 transferase activity 1 172 0.5 0.4099 GO:0042981 regulation of apoptosis 2 460 1.3 0.410627 GO:0016874 ligase activity 1 174 0.5 0.413531 GO:0043067 regulation of programmed cell death 1 176 0.5 0.41714 GO:0004857 enzyme inhibitor activity 1 634 1.9 0.419056 u GO:0005886 plasma membrane 5 1393 4.2 0.420185 GO:0006355 regulation of transcription, DNA-dependent 1 180 0.5 0.424292 GO:0000267 cell fraction 1 181 0.5 0.426067 GO:0009308 amine metabolism 1 625 1.9 0.426973 u GO:0005198 structural molecule activity 1 619 1.8 0.432308 u GO:0008283 cell proliferation 5 1417 4.3 0.435143 GO:0006351 transcription, DNA-dependent 1 187 0.5 0.436604 GO:0016791 phosphoric monoester hydrolase activity 27 9173 27.9 0.440824 u GO:0005623 cell 8 2384 7.2 0.442568 GO:0019538 protein metabolism 1 599 1.8 0.450422 u GO:0016491 oxidoreductase activity 1 596 1.8 0.453182 u GO:0003700 transcription factor activity 5 1452 4.4 0.456843 GO:0045449 regulation of transcription 1 200 0.6 0.458789 GO:0005829 cytosol 5 1458 4.4 0.460547 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 204 0.6 0.465442 GO:0007264 small GTPase mediated signal transduction 1 204 0.6 0.465442 GO:0009628 response to abiotic stimulus 1 212 0.6 0.478509 GO:0016192 vesicle-mediated transport 1 218 0.6 0.488104 GO:0006886 intracellular protein transport 2 884 2.6 0.490268 u GO:0050874 organismal physiological process 1 221 0.6 0.492836 GO:0005261 cation channel activity 5 1516 4.6 0.496011 GO:0006350 transcription 2 872 2.6 0.499608 u GO:0009058 biosynthesis 6 1874 5.7 0.514137 GO:0046872 metal ion binding 1 238 0.7 0.518858 GO:0016070 RNA metabolism 5 1564 4.7 0.524794 GO:0019222 regulation of metabolism 1 517 1.5 0.529799 u GO:0006950 response to stress 5 1795 5.4 0.529856 u GO:0016787 hydrolase activity 1 250 0.7 0.536436 GO:0016887 ATPase activity 14 4555 13.8 0.539441 GO:0016020 membrane 2 594 1.8 0.544971 GO:0016788 hydrolase activity, acting on ester bonds 5 1606 4.8 0.549459 GO:0050791 regulation of physiological process 1 262 0.7 0.553387 GO:0019752 carboxylic acid metabolism 1 264 0.8 0.556153 GO:0016567 protein ubiquitination 1 491 1.4 0.556567 u GO:0007049 cell cycle 1 265 0.8 0.557529 GO:0006082 organic acid metabolism 1 268 0.8 0.561634 GO:0000151 ubiquitin ligase complex 2 620 1.8 0.568585 GO:0006811 ion transport 2 622 1.8 0.570366 GO:0008233 peptidase activity 8 2670 8.1 0.573567 u GO:0005634 nucleus 2 776 2.3 0.576968 u GO:0030528 transcription regulator activity 1 280 0.8 0.577683 GO:0005794 Golgi apparatus 2 632 1.9 0.579194 GO:0005739 mitochondrion 1 456 1.3 0.59367 u GO:0004175 endopeptidase activity 1 294 0.8 0.595683 GO:0030154 cell differentiation 1 297 0.9 0.599442 GO:0030001 metal ion transport 1 301 0.9 0.6044 GO:0005216 ion channel activity 1 444 1.3 0.606646 u GO:0006412 protein biosynthesis 5 1656 5 0.608767 u GO:0006810 transport 1 307 0.9 0.611725 GO:0004842 ubiquitin-protein ligase activity 1 309 0.9 0.614137 GO:0006915 apoptosis 1 313 0.9 0.618918 GO:0012501 programmed cell death 2 724 2.2 0.620339 u GO:0009059 macromolecule biosynthesis 1 325 0.9 0.632915 GO:0015268 alpha-type channel activity 1 326 0.9 0.634058 GO:0016881 acid-D-amino acid ligase activity 1 399 1.2 0.656264 u GO:0006812 cation transport 1 368 1.1 0.691109 u GO:0006512 ubiquitin cycle 1 360 1 0.700158 u GO:0016879 ligase activity, forming carbon-nitrogen bonds 1 358 1 0.702423 u GO:0015031 protein transport 1 350 1 0.711488 u GO:0006629 lipid metabolism 1 348 1 0.713756 u GO:0016817 hydrolase activity, acting on acid anhydrides 1 346 1 0.716025 u GO:0016265 death 1 345 1 0.717159 u GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 343 1 0.719428 u GO:0008219 cell death 1 333 1 0.730776 u GO:0015267 channel/pore class transporter activity