# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 97 #b referenced loci : 92 #c annotated loci : 81 #d hyper-geometric : n 81 hgN 14129 #e k hgK Exp k p-value term description 26 2064 11.8 5.21526e-05 GO:0005515 protein binding 11 514 2.9 0.000160516 GO:0005856 cytoskeleton 3 21 0.1 0.000224095 GO:0043087 regulation of GTPase activity 5 2958 16.9 0.000229176 u GO:0004871 signal transducer activity 56 7041 40.3 0.000325869 GO:0005488 binding 2 6 0 0.000479722 GO:0019894 kinesin binding 2 1922 11 0.000659282 u GO:0007166 cell surface receptor linked signal transduction 4 73 0.4 0.000808051 GO:0005875 microtubule associated complex 4 74 0.4 0.000850534 GO:0005516 calmodulin binding 12 749 4.2 0.00109718 GO:0016301 kinase activity 5 138 0.7 0.0011685 GO:0015630 microtubule cytoskeleton 4 2359 13.5 0.00128854 u GO:0004872 receptor activity 9 3552 20.3 0.0013772 u GO:0016021 integral to membrane 17 1366 7.8 0.00165092 GO:0017076 purine nucleotide binding 17 1374 7.8 0.00175864 GO:0000166 nucleotide binding 15 1161 6.6 0.00224587 GO:0006464 protein modification 14 1067 6.1 0.002778 GO:0005524 ATP binding 3 50 0.2 0.00293055 GO:0050790 regulation of enzyme activity 14 1078 6.1 0.00305066 GO:0030554 adenyl nucleotide binding 2 1597 9.1 0.00378805 u GO:0007186 G-protein coupled receptor protein signaling pathway 1 1 0 0.00573289 GO:0004438 phosphatidylinositol-3-phosphatase activity 1 1 0 0.00573289 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00573289 GO:0008089 anterograde axon cargo transport 1 1 0 0.00573289 GO:0016939 kinesin II complex 1 1 0 0.00573289 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00573289 GO:0030325 adrenal gland development 6 286 1.6 0.00595599 GO:0007028 cytoplasm organization and biogenesis 6 307 1.7 0.00832079 GO:0004842 ubiquitin-protein ligase activity 5 222 1.2 0.00892329 GO:0008092 cytoskeletal protein binding 6 326 1.8 0.0109862 GO:0016881 acid-D-amino acid ligase activity 1 2 0 0.0114333 GO:0000209 protein polyubiquitination 1 2 0 0.0114333 GO:0001672 regulation of chromatin assembly/disassembly 1 2 0 0.0114333 GO:0030517 negative regulation of axon extension 1 2 0 0.0114333 GO:0045646 regulation of erythrocyte differentiation 1 2 0 0.0114333 GO:0045648 positive regulation of erythrocyte differentiation 3 84 0.4 0.0123976 GO:0007017 microtubule-based process 5 244 1.3 0.0130438 GO:0006996 organelle organization and biogenesis 9 669 3.8 0.01414 GO:0006793 phosphorus metabolism 9 669 3.8 0.01414 GO:0006796 phosphate metabolism 6 345 1.9 0.0142095 GO:0004674 protein serine/threonine kinase activity 42 5553 31.8 0.0145036 GO:0005622 intracellular 7 460 2.6 0.016259 GO:0016874 ligase activity 1 3 0 0.0171015 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1 3 0 0.0171015 GO:0004828 serine-tRNA ligase activity 1 3 0 0.0171015 GO:0005869 dynactin complex 1 3 0 0.0171015 GO:0006434 seryl-tRNA aminoacylation 1 3 0 0.0171015 GO:0042147 retrograde transport, endosome to Golgi 6 360 2 0.0171834 GO:0016879 ligase activity, forming carbon-nitrogen bonds 17 4555 26.1 0.0173837 u GO:0016020 membrane 8 582 3.3 0.0181844 GO:0016043 cell organization and biogenesis 6 368 2.1 0.0189339 GO:0006512 ubiquitin cycle 2 38 0.2 0.0199697 GO:0007018 microtubule-based movement 2 38 0.2 0.0199697 GO:0030705 cytoskeleton-dependent intracellular transport 3 102 0.5 0.020765 GO:0045202 synapse 1 4 0 0.0227375 GO:0007435 salivary gland morphogenesis 1 4 0 0.0227375 GO:0008088 axon cargo transport 1 4 0 0.0227375 GO:0045639 positive regulation of myeloid blood cell differentiation 1 4 0 0.0227375 GO:0045767 regulation of anti-apoptosis 7 496 2.8 0.023487 GO:0004672 protein kinase activity 7 509 2.9 0.0265723 GO:0006468 protein amino acid phosphorylation 1 5 0 0.0283416 GO:0000145 exocyst 1 5 0 0.0283416 GO:0007044 cell-substrate junction assembly 1 5 0 0.0283416 GO:0008717 D-alanyl-D-alanine endopeptidase activity 1 5 0 0.0283416 GO:0017137 Rab interactor activity 1 5 0 0.0283416 GO:0030516 regulation of axon extension 1 5 0 0.0283416 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0283416 GO:0030866 cortical actin cytoskeleton organization and biogenesis 4 204 1.1 0.0296566 GO:0007010 cytoskeleton organization and biogenesis 2 49 0.2 0.0320842 GO:0005789 endoplasmic reticulum membrane 2 50 0.2 0.033299 GO:0042175 nuclear envelope-endoplasmic reticulum network 1 6 0 0.033914 GO:0001658 ureteric bud branching 1 6 0 0.033914 GO:0003756 protein disulfide isomerase activity 1 6 0 0.033914 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.033914 GO:0007431 salivary gland development 1 6 0 0.033914 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1 6 0 0.033914 GO:0042577 lipid phosphatase activity 9 2728 15.6 0.0354093 u GO:0007165 signal transduction 3 131 0.7 0.0393881 GO:0003774 motor activity 1 7 0 0.0394548 GO:0005388 calcium-transporting ATPase activity 1 7 0 0.0394548 GO:0006564 L-serine biosynthesis 1 7 0 0.0394548 GO:0015085 calcium ion transporter activity 18 2048 11.7 0.0396445 GO:0050789 regulation of biological process 7 559 3.2 0.0410136 GO:0016310 phosphorylation 1 8 0 0.0449643 GO:0005871 kinesin complex 1 8 0 0.0449643 GO:0007595 lactation 1 8 0 0.0449643 GO:0015035 protein disulfide oxidoreductase activity 1 8 0 0.0449643 GO:0030218 erythrocyte differentiation 1 8 0 0.0449643 GO:0030659 cytoplasmic vesicle membrane 3 139 0.7 0.0456266 GO:0030695 GTPase regulator activity 2 62 0.3 0.0492001 GO:0004840 ubiquitin conjugating enzyme activity 2 62 0.3 0.0492001 GO:0008639 small protein conjugating enzyme activity 22 2707 15.5 0.0495076 GO:0005737 cytoplasm 1 9 0 0.0504425 GO:0016581 NuRD complex 7 586 3.3 0.0506194 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 10 0 0.0558897 GO:0001763 branching morphogenesis 1 10 0 0.0558897 GO:0004685 calcium/calmodulin-dependent protein kinase activity 1 10 0 0.0558897 GO:0006563 L-serine metabolism 1 10 0 0.0558897 GO:0009070 serine family amino acid biosynthesis 1 10 0 0.0558897 GO:0042060 wound healing 3 152 0.8 0.0567413 GO:0000067 DNA replication and chromosome cycle 2 70 0.4 0.0610336 GO:0006816 calcium ion transport 1 11 0 0.061306 GO:0001657 ureteric bud development 1 11 0 0.061306 GO:0004550 nucleoside-diphosphate kinase activity 1 11 0 0.061306 GO:0006183 GTP biosynthesis 1 11 0 0.061306 GO:0006228 UTP biosynthesis 1 11 0 0.061306 GO:0006241 CTP biosynthesis 1 11 0 0.061306 GO:0009208 pyrimidine ribonucleoside triphosphate metabolism 1 11 0 0.061306 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthesis 1 11 0 0.061306 GO:0009218 pyrimidine ribonucleotide metabolism 1 11 0 0.061306 GO:0009220 pyrimidine ribonucleotide biosynthesis 1 11 0 0.061306 GO:0042472 inner ear morphogenesis 1 11 0 0.061306 GO:0046036 CTP metabolism 1 11 0 0.061306 GO:0046039 GTP metabolism 1 11 0 0.061306 GO:0046051 UTP metabolism 1 11 0 0.061306 GO:0051052 regulation of DNA metabolism 3 157 0.9 0.0613292 GO:0012505 endomembrane system 4 264 1.5 0.0650134 GO:0016567 protein ubiquitination 1 12 0 0.0666916 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0 0.0666916 GO:0042471 ear morphogenesis 4 268 1.5 0.0679187 GO:0000151 ubiquitin ligase complex 1 13 0 0.0720467 GO:0005938 cell cortex 1 13 0 0.0720467 GO:0006446 regulation of translational initiation 1 13 0 0.0720467 GO:0007548 sex differentiation 1 13 0 0.0720467 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 1 13 0 0.0720467 GO:0016197 endosome transport 1 13 0 0.0720467 GO:0016998 cell wall catabolism 1 13 0 0.0720467 GO:0042493 response to drug 8 771 4.4 0.073871 GO:0016772 transferase activity, transferring phosphorus-containing groups 1 14 0 0.0773714 GO:0004683 calmodulin regulated protein kinase activity 1 14 0 0.0773714 GO:0006700 C21-steroid hormone biosynthesis 1 14 0 0.0773714 GO:0009069 serine family amino acid metabolism 1 14 0 0.0773714 GO:0012506 vesicle membrane 1 14 0 0.0773714 GO:0046777 autophosphorylation 19 2384 13.6 0.0792722 GO:0019538 protein metabolism 1 15 0 0.082666 GO:0008207 C21-steroid hormone metabolism 1 15 0 0.082666 GO:0045637 regulation of myeloid blood cell differentiation 1 16 0 0.0879306 GO:0005520 insulin-like growth factor binding 1 16 0 0.0879306 GO:0007059 chromosome segregation 1 16 0 0.0879306 GO:0030176 integral to endoplasmic reticulum membrane 1 17 0 0.0931653 GO:0000118 histone deacetylase complex 1 17 0 0.0931653 GO:0007032 endosome organization and biogenesis 1 17 0 0.0931653 GO:0016323 basolateral plasma membrane 3 1147 6.5 0.0963612 u GO:0005215 transporter activity 32 4537 26 0.0964945 GO:0003824 catalytic activity 2 92 0.5 0.0977187 GO:0005083 small GTPase regulatory/interacting protein activity 1 18 0.1 0.0983704 GO:0001656 metanephros development 1 18 0.1 0.0983704 GO:0001822 kidney development 1 18 0.1 0.0983704 GO:0004437 inositol/phosphatidylinositol phosphatase activity 1 18 0.1 0.0983704 GO:0042446 hormone biosynthesis 1 19 0.1 0.103546 GO:0001655 urogenital system development 1 19 0.1 0.103546 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0.1 0.103546 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0.1 0.103546 GO:0030286 dynein complex 1 20 0.1 0.108692 GO:0045597 positive regulation of cell differentiation 4 321 1.8 0.112488 GO:0046907 intracellular transport 1 21 0.1 0.113809 GO:0000082 G1/S transition of mitotic cell cycle 1 22 0.1 0.118897 GO:0006221 pyrimidine nucleotide biosynthesis 1 613 3.5 0.127887 u GO:0009057 macromolecule catabolism 1 24 0.1 0.128987 GO:0003777 microtubule motor activity 1 24 0.1 0.128987 GO:0006112 energy reserve metabolism 1 24 0.1 0.128987 GO:0006953 acute-phase response 1 24 0.1 0.128987 GO:0015082 di-, tri-valent inorganic cation transporter activity 1 24 0.1 0.128987 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1 24 0.1 0.128987 GO:0019933 cAMP-mediated signaling 1 610 3.4 0.129689 u GO:0030163 protein catabolism 2 110 0.6 0.131228 GO:0006470 protein amino acid dephosphorylation 2 110 0.6 0.131228 GO:0015674 di-, tri-valent inorganic cation transport 1 25 0.1 0.133989 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1 25 0.1 0.133989 GO:0008017 microtubule binding 2 112 0.6 0.135102 GO:0006357 regulation of transcription from Pol II promoter 2 112 0.6 0.135102 GO:0016311 dephosphorylation 1 590 3.3 0.142304 u GO:0006508 proteolysis and peptidolysis 1 27 0.1 0.143907 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1 27 0.1 0.143907 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 2 118 0.6 0.146871 GO:0000278 mitotic cell cycle 1 28 0.1 0.148825 GO:0019935 cyclic-nucleotide-mediated signaling 2 119 0.6 0.148853 GO:0007243 protein kinase cascade 2 119 0.6 0.148853 GO:0009790 embryonic development 4 358 2 0.149654 GO:0015031 protein transport 5 491 2.8 0.150766 GO:0007049 cell cycle 2 122 0.6 0.154832 GO:0007268 synaptic transmission 2 797 4.5 0.157187 u GO:0009056 catabolism 1 30 0.1 0.158576 GO:0015631 tubulin binding 5 500 2.8 0.158964 GO:0005509 calcium ion binding 3 243 1.3 0.163119 GO:0042578 phosphoric ester hydrolase activity 14 3170 18.1 0.163308 u GO:0007154 cell communication 1 31 0.1 0.16341 GO:0015036 disulfide oxidoreductase activity 1 31 0.1 0.16341 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity 1 31 0.1 0.16341 GO:0019838 growth factor binding 1 31 0.1 0.16341 GO:0050876 reproductive physiological process 2 127 0.7 0.164899 GO:0043037 translation 2 128 0.7 0.166927 GO:0004721 phosphoprotein phosphatase activity 2 128 0.7 0.166927 GO:0019226 transmission of nerve impulse 2 128 0.7 0.166927 GO:0050905 neuromuscular physiological process 2 129 0.7 0.168958 GO:0006260 DNA replication 1 33 0.1 0.172996 GO:0003702 RNA polymerase II transcription factor activity 1 33 0.1 0.172996 GO:0005200 structural constituent of cytoskeleton 1 33 0.1 0.172996 GO:0016860 intramolecular oxidoreductase activity 5 517 2.9 0.174939 GO:0006950 response to stress 2 132 0.7 0.17508 GO:0006520 amino acid metabolism 6 660 3.7 0.177157 GO:0007242 intracellular signaling cascade 1 34 0.1 0.177748 GO:0006887 exocytosis 1 34 0.1 0.177748 GO:0008652 amino acid biosynthesis 4 384 2.2 0.178264 GO:0030234 enzyme regulator activity 12 1564 8.9 0.181301 GO:0019222 regulation of metabolism 4 390 2.2 0.185121 GO:0007155 cell adhesion 29 5831 33.4 0.187376 u GO:0009987 cellular process 1 37 0.2 0.191843 GO:0007411 axon guidance 1 37 0.2 0.191843 GO:0019932 second-messenger-mediated signaling 2 144 0.8 0.199893 GO:0050793 regulation of development 1 39 0.2 0.201108 GO:0006418 tRNA aminoacylation for protein translation 1 39 0.2 0.201108 GO:0030099 myeloid blood cell differentiation 1 39 0.2 0.201108 GO:0042445 hormone metabolism 1 39 0.2 0.201108 GO:0043038 amino acid activation 1 39 0.2 0.201108 GO:0043039 tRNA aminoacylation 3 270 1.5 0.201789 GO:0005578 extracellular matrix 2 146 0.8 0.204071 GO:0006366 transcription from Pol II promoter 12 1606 9.2 0.205617 GO:0050791 regulation of physiological process 1 40 0.2 0.2057 GO:0000165 MAPKKK cascade 1 40 0.2 0.2057 GO:0006445 regulation of translation 1 41 0.2 0.210267 GO:0004812 tRNA ligase activity 1 41 0.2 0.210267 GO:0006694 steroid biosynthesis 1 41 0.2 0.210267 GO:0008201 heparin binding 1 41 0.2 0.210267 GO:0008452 RNA ligase activity 1 41 0.2 0.210267 GO:0016875 ligase activity, forming carbon-oxygen bonds 1 41 0.2 0.210267 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 2 149 0.8 0.210358 GO:0006974 response to DNA damage stimulus 11 1458 8.3 0.210739 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 12 2672 15.3 0.214362 u GO:0003676 nucleic acid binding 2 151 0.8 0.21456 GO:0007267 cell-cell signaling 1 42 0.2 0.214807 GO:0006400 tRNA modification 1 42 0.2 0.214807 GO:0006413 translational initiation 1 42 0.2 0.214807 GO:0006986 response to unfolded protein 3 280 1.6 0.216639 GO:0005794 Golgi apparatus 1 44 0.2 0.223811 GO:0007420 brain development 3 286 1.6 0.22566 GO:0005525 GTP binding 2 157 0.9 0.227213 GO:0009719 response to endogenous stimulus 52 8414 48.2 0.230457 GO:0007582 physiological process 1 46 0.2 0.232714 GO:0009795 embryonic morphogenesis 2 160 0.9 0.233561 GO:0003779 actin binding 49 9173 52.5 0.233841 u GO:0005623 cell 1 47 0.2 0.237127 GO:0005262 calcium channel activity 1 47 0.2 0.237127 GO:0009145 purine nucleoside triphosphate biosynthesis 1 47 0.2 0.237127 GO:0009201 ribonucleoside triphosphate biosynthesis 1 47 0.2 0.237127 GO:0009206 purine ribonucleoside triphosphate biosynthesis 1 47 0.2 0.237127 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1 47 0.2 0.237127 GO:0016886 ligase activity, forming phosphoric ester bonds 1 47 0.2 0.237127 GO:0045211 postsynaptic membrane 2 162 0.9 0.2378 GO:0004713 protein-tyrosine kinase activity 3 294 1.6 0.237802 GO:0019001 guanyl nucleotide binding 1 49 0.2 0.245878 GO:0009451 RNA modification 2 167 0.9 0.248415 GO:0006519 amino acid and derivative metabolism 1 51 0.2 0.25453 GO:0009142 nucleoside triphosphate biosynthesis 1 51 0.2 0.25453 GO:0009199 ribonucleoside triphosphate metabolism 1 51 0.2 0.25453 GO:0009205 purine ribonucleoside triphosphate metabolism 1 51 0.2 0.25453 GO:0046873 metal ion transporter activity 1 456 2.6 0.258723 u GO:0004175 endopeptidase activity 8 1058 6 0.259425 GO:0050896 response to stimulus 18 2670 15.3 0.260477 GO:0005634 nucleus 1 53 0.3 0.263084 GO:0009144 purine nucleoside triphosphate metabolism 1 53 0.3 0.263084 GO:0009309 amine biosynthesis 1 55 0.3 0.271541 GO:0004221 ubiquitin thiolesterase activity 1 55 0.3 0.271541 GO:0004725 protein tyrosine phosphatase activity 10 1393 7.9 0.274417 GO:0006355 regulation of transcription, DNA-dependent 1 56 0.3 0.275733 GO:0005539 glycosaminoglycan binding 1 56 0.3 0.275733 GO:0009152 purine ribonucleotide biosynthesis 1 56 0.3 0.275733 GO:0016563 transcriptional activator activity 3 319 1.8 0.276408 GO:0050877 neurophysiological process 2 181 1 0.2782 GO:0009308 amine metabolism 1 57 0.3 0.279902 GO:0004843 ubiquitin-specific protease activity 1 57 0.3 0.279902 GO:0015992 proton transport 5 619 3.5 0.281518 GO:0008283 cell proliferation 2 183 1 0.282454 GO:0050879 organismal movement 1 58 0.3 0.284047 GO:0001558 regulation of cell growth 1 58 0.3 0.284047 GO:0005730 nucleolus 1 58 0.3 0.284047 GO:0006818 hydrogen transport 1 58 0.3 0.284047 GO:0006916 anti-apoptosis 1 59 0.3 0.288168 GO:0005635 nuclear membrane 1 59 0.3 0.288168 GO:0008081 phosphoric diester hydrolase activity 1 59 0.3 0.288168 GO:0009260 ribonucleotide biosynthesis 5 625 3.5 0.288209 GO:0005198 structural molecule activity 3 327 1.8 0.288914 GO:0005783 endoplasmic reticulum 2 634 3.6 0.289316 u GO:0005886 plasma membrane 2 187 1 0.290958 GO:0016791 phosphoric monoester hydrolase activity 2 632 3.6 0.291354 u GO:0005739 mitochondrion 10 1417 8.1 0.292337 GO:0006351 transcription, DNA-dependent 1 61 0.3 0.296341 GO:0006164 purine nucleotide biosynthesis 1 62 0.3 0.300393 GO:0005096 GTPase activator activity 1 62 0.3 0.300393 GO:0007417 central nervous system development 1 62 0.3 0.300393 GO:0009150 purine ribonucleotide metabolism 1 63 0.3 0.304421 GO:0007409 axonogenesis 1 63 0.3 0.304421 GO:0016568 chromatin modification 1 63 0.3 0.304421 GO:0030036 actin cytoskeleton organization and biogenesis 18 2750 15.7 0.305219 GO:0008151 cell growth and/or maintenance 1 64 0.3 0.308427 GO:0003743 translation initiation factor activity 1 65 0.3 0.312409 GO:0006399 tRNA metabolism 1 66 0.3 0.316369 GO:0009259 ribonucleotide metabolism 1 66 0.3 0.316369 GO:0043066 negative regulation of apoptosis 1 66 0.3 0.316369 GO:0043069 negative regulation of programmed cell death 4 496 2.8 0.316977 GO:0050794 regulation of cellular process 3 345 1.9 0.317202 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 10 1452 8.3 0.319058 GO:0045449 regulation of transcription 1 67 0.3 0.320307 GO:0030029 actin filament-based process 36 5837 33.4 0.320693 GO:0008152 metabolism 3 348 1.9 0.321928 GO:0016817 hydrolase activity, acting on acid anhydrides 1 68 0.3 0.324222 GO:0003924 GTPase activity 1 69 0.3 0.328115 GO:0006163 purine nucleotide metabolism 1 69 0.3 0.328115 GO:0016790 thiolester hydrolase activity 1 69 0.3 0.328115 GO:0045045 secretory pathway 2 596 3.4 0.329891 u GO:0003700 transcription factor activity 1 70 0.4 0.331986 GO:0045595 regulation of cell differentiation 1 71 0.4 0.335834 GO:0042625 ATPase activity, coupled to transmembrane movement of ions 1 72 0.4 0.339661 GO:0016049 cell growth 2 212 1.2 0.343714 GO:0016192 vesicle-mediated transport 1 75 0.4 0.351012 GO:0008361 regulation of cell size 1 78 0.4 0.362169 GO:0040008 regulation of growth 1 375 2.1 0.362276 u GO:0003723 RNA binding 1 79 0.4 0.365846 GO:0009966 regulation of signal transduction 10 1516 8.6 0.369284 GO:0006350 transcription 1 81 0.4 0.373137 GO:0000087 M phase of mitotic cell cycle 1 81 0.4 0.373137 GO:0007067 mitosis 1 82 0.4 0.376752 GO:0008202 steroid metabolism 1 83 0.4 0.380346 GO:0007156 homophilic cell adhesion 1 85 0.4 0.387472 GO:0015405 P-P-bond-hydrolysis-driven transporter activity 12 1874 10.7 0.387535 GO:0046872 metal ion binding 1 87 0.4 0.394517 GO:0009147 pyrimidine nucleoside triphosphate metabolism 6 884 5 0.39628 GO:0050874 organismal physiological process 1 88 0.5 0.39801 GO:0006417 regulation of protein biosynthesis 1 350 2 0.40007 u GO:0006629 lipid metabolism 5 723 4.1 0.400205 GO:0005576 extracellular 1 90 0.5 0.404936 GO:0008047 enzyme activator activity 1 346 1.9 0.406379 u GO:0016265 death 1 91 0.5 0.408369 GO:0004867 serine-type endopeptidase inhibitor activity 9 1795 10.2 0.410972 u GO:0016787 hydrolase activity 1 343 1.9 0.411159 u GO:0008219 cell death 1 92 0.5 0.411783 GO:0009889 regulation of biosynthesis 1 94 0.5 0.418552 GO:0006220 pyrimidine nucleotide metabolism 1 337 1.9 0.42084 u GO:0006118 electron transport 2 250 1.4 0.421314 GO:0016887 ATPase activity 1 96 0.5 0.425244 GO:0008135 translation factor activity, nucleic acid binding 1 333 1.9 0.427385 u GO:0015267 channel/pore class transporter activity 1 97 0.5 0.428562 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7 1415 8.1 0.428879 u GO:0007275 development 19 3131 17.9 0.431842 GO:0050875 cellular physiological process 1 99 0.5 0.43514 GO:0045182 translation regulator activity 2 259 1.4 0.439044 GO:0007399 neurogenesis 10 1604 9.1 0.439813 GO:0003677 DNA binding 1 325 1.8 0.44069 u GO:0015268 alpha-type channel activity 6 1221 6.9 0.442552 u GO:0046914 transition metal ion binding 1 102 0.5 0.444868 GO:0006511 ubiquitin-dependent protein catabolism 1 102 0.5 0.444868 GO:0009165 nucleotide biosynthesis 1 102 0.5 0.444868 GO:0019941 modification-dependent protein catabolism 2 262 1.5 0.44489 GO:0019752 carboxylic acid metabolism 4 594 3.4 0.444934 GO:0016788 hydrolase activity, acting on ester bonds 1 103 0.5 0.448074 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2 265 1.5 0.450702 GO:0006082 organic acid metabolism 1 106 0.6 0.457581 GO:0005667 transcription factor complex 1 106 0.6 0.457581 GO:0016477 cell migration 1 107 0.6 0.460715 GO:0030097 hemopoiesis 1 313 1.7 0.461182 u GO:0012501 programmed cell death 1 108 0.6 0.46383 GO:0006333 chromatin assembly/disassembly 1 311 1.7 0.464659 u GO:0005386 carrier activity 1 309 1.7 0.468154 u GO:0006915 apoptosis 1 110 0.6 0.470007 GO:0000280 nuclear division 2 480 2.7 0.477376 u GO:0006952 defense response 1 113 0.6 0.479141 GO:0016337 cell-cell adhesion 1 113 0.6 0.479141 GO:0040007 growth 10 1656 9.4 0.481464 GO:0006810 transport 1 114 0.6 0.482152 GO:0015980 energy derivation by oxidation of organic compounds 1 301 1.7 0.482307 u GO:0005216 ion channel activity 1 115 0.6 0.485145 GO:0000279 M phase 1 117 0.6 0.491079 GO:0008234 cysteine-type peptidase activity 1 294 1.6 0.494916 u GO:0030154 cell differentiation 1 120 0.6 0.499855 GO:0006091 energy pathways 13 2374 13.6 0.500088 u GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 121 0.6 0.502747 GO:0016853 isomerase activity 1 123 0.7 0.508481 GO:0005489 electron transporter activity 1 123 0.7 0.508481 GO:0042221 response to chemical substance 2 297 1.7 0.510514 GO:0030001 metal ion transport 1 124 0.7 0.511323 GO:0019028 viral capsid 5 822 4.7 0.511991 GO:0009653 morphogenesis 1 125 0.7 0.51415 GO:0006281 DNA repair 1 125 0.7 0.51415 GO:0019012 virion 3 622 3.5 0.519445 u GO:0008233 peptidase activity 1 127 0.7 0.519754 GO:0042626 ATPase activity, coupled to transmembrane movement of substances 3 620 3.5 0.521963 u GO:0006811 ion transport 1 129 0.7 0.525294 GO:0009141 nucleoside triphosphate metabolism 1 130 0.7 0.528041 GO:0015629 actin cytoskeleton 1 130 0.7 0.528041 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2 444 2.5 0.529628 u GO:0006412 protein biosynthesis 1 131 0.7 0.530772 GO:0004866 endopeptidase inhibitor activity 1 131 0.7 0.530772 GO:0015399 primary active transporter activity 1 132 0.7 0.533487 GO:0030414 protease inhibitor activity 8 1372 7.8 0.534746 GO:0016740 transferase activity 4 776 4.4 0.539236 u GO:0030528 transcription regulator activity 1 135 0.7 0.54154 GO:0000902 cellular morphogenesis 3 599 3.4 0.548651 u GO:0016491 oxidoreductase activity 1 139 0.7 0.552064 GO:0016023 cytoplasmic vesicle 1 140 0.8 0.554657 GO:0005244 voltage-gated ion channel activity 1 141 0.8 0.557236 GO:0000287 magnesium ion binding 1 141 0.8 0.557236 GO:0008610 lipid biosynthesis 3 505 2.8 0.557266 GO:0006259 DNA metabolism 6 1095 6.2 0.559985 u GO:0008270 zinc ion binding 5 872 4.9 0.565437 GO:0009058 biosynthesis 2 420 2.4 0.565781 u GO:0006955 immune response 1 146 0.8 0.56991 GO:0009611 response to wounding 3 578 3.3 0.575727 u GO:0009607 response to biotic stimulus 2 399 2.2 0.598091 u GO:0006812 cation transport 4 724 4.1 0.598644 u GO:0009059 macromolecule biosynthesis 1 158 0.9 0.598883 GO:0006323 DNA packaging 1 158 0.9 0.598883 GO:0006325 establishment and/or maintenance of chromatin architecture 1 158 0.9 0.598883 GO:0006928 cell motility 1 238 1.3 0.602746 u GO:0016070 RNA metabolism 1 238 1.3 0.602746 u GO:0042623 ATPase activity, coupled 1 235 1.3 0.608832 u GO:0009613 response to pest/pathogen/parasite 5 879 5 0.608929 u GO:0009605 response to external stimulus 1 165 0.9 0.614885 GO:0005624 membrane fraction 1 166 0.9 0.617119 GO:0006457 protein folding 1 230 1.3 0.619032 u GO:0015672 monovalent inorganic cation transport 1 170 0.9 0.625927 GO:0008324 cation transporter activity 1 171 0.9 0.628098 GO:0005654 nucleoplasm 4 698 4 0.628595 u GO:0009887 organogenesis 1 172 0.9 0.630256 GO:0042981 regulation of apoptosis 1 224 1.2 0.631362 u GO:0015075 ion transporter activity 1 174 0.9 0.634536 GO:0043067 regulation of programmed cell death 1 221 1.2 0.637562 u GO:0005261 cation channel activity 1 218 1.2 0.643783 u GO:0006886 intracellular protein transport 1 214 1.2 0.65211 u GO:0009117 nucleotide metabolism 1 211 1.2 0.658377 u GO:0009581 detection of external stimulus 1 204 1.1 0.673068 u GO:0007264 small GTPase mediated signal transduction 1 204 1.1 0.673068 u GO:0009628 response to abiotic stimulus 1 200 1.1 0.6815 u GO:0005829 cytosol 1 197 1.1 0.687839 u GO:0007600 sensory perception 1 187 1 0.709042 u GO:0006997 nuclear organization and biogenesis 1 181 1 0.7218 u GO:0007001 chromosome organization and biogenesis (sensu Eukarya) 1 180 1 0.723928 u GO:0000267 cell fraction 1 176 1 0.732441 u GO:0004857 enzyme inhibitor activity