# /cluster/home/jill/chuck/mm5/pval/go/bg/kgJillIsoforms.tab 41208, /cluster/home/jill/chuck/mm5/pval/go/bg/kgMrnaGo.tab 92287, /cluster/home/jill/chuck/mm5/pval/go/bg/goKgAncestors.tab 3801, /cluster/home/jill/chuck/mm5/pval/go/bg/mm5.knownGene.out 5087 #a instance list : 177 #b referenced loci : 163 #c annotated loci : 133 #d hyper-geometric : n 133 hgN 14129 #e k hgK Exp k p-value term description 3 1922 18 5.80259e-06 u GO:0007166 cell surface receptor linked signal transduction 13 3552 33.4 6.21006e-06 u GO:0016021 integral to membrane 39 2064 19.4 9.30851e-06 GO:0005515 protein binding 91 7041 66.2 1.0014e-05 GO:0005488 binding 2 1597 15 1.78292e-05 u GO:0007186 G-protein coupled receptor protein signaling pathway 20 749 7 2.25943e-05 GO:0016301 kinase activity 4 21 0.1 3.96654e-05 GO:0043087 regulation of GTPase activity 11 2958 27.8 6.34649e-05 u GO:0004871 signal transducer activity 15 514 4.8 9.85519e-05 GO:0005856 cytoskeleton 24 1161 10.9 0.000193975 GO:0006464 protein modification 8 2359 22.2 0.000194234 u GO:0004872 receptor activity 22 1067 10 0.000385525 GO:0005524 ATP binding 22 1078 10.1 0.000443737 GO:0030554 adenyl nucleotide binding 5 73 0.6 0.000616638 GO:0005875 microtubule associated complex 5 74 0.6 0.000656385 GO:0005516 calmodulin binding 71 5553 52.2 0.000658951 GO:0005622 intracellular 26 4555 42.8 0.000756064 u GO:0016020 membrane 2 5 0 0.000863296 GO:0008717 D-alanyl-D-alanine endopeptidase activity 25 1366 12.8 0.000876576 GO:0017076 purine nucleotide binding 25 1374 12.9 0.000953344 GO:0000166 nucleotide binding 4 50 0.4 0.00123602 GO:0050790 regulation of enzyme activity 2 6 0 0.00128696 GO:0019894 kinesin binding 10 345 3.2 0.00156747 GO:0004674 protein serine/threonine kinase activity 6 138 1.2 0.0019366 GO:0015630 microtubule cytoskeleton 9 307 2.8 0.00248432 GO:0004842 ubiquitin-protein ligase activity 10 368 3.4 0.00251324 GO:0006512 ubiquitin cycle 9 326 3 0.00370014 GO:0016881 acid-D-amino acid ligase activity 11 460 4.3 0.00412556 GO:0016874 ligase activity 14 669 6.2 0.00417847 GO:0006793 phosphorus metabolism 14 669 6.2 0.00417847 GO:0006796 phosphate metabolism 7 222 2 0.0050345 GO:0008092 cytoskeletal protein binding 34 2384 22.4 0.00697964 GO:0019538 protein metabolism 9 360 3.3 0.00699792 GO:0016879 ligase activity, forming carbon-nitrogen bonds 11 496 4.6 0.00717176 GO:0004672 protein kinase activity 2 14 0.1 0.00743168 GO:0046777 autophosphorylation 11 509 4.7 0.00862714 GO:0006468 protein amino acid phosphorylation 15 2728 25.6 0.0091266 u GO:0007165 signal transduction 12 586 5.5 0.00927416 GO:0016773 phosphotransferase activity, alcohol group as acceptor 1 1 0 0.00941326 GO:0004438 phosphatidylinositol-3-phosphatase activity 1 1 0 0.00941326 GO:0007274 neuromuscular synaptic transmission 1 1 0 0.00941326 GO:0008089 anterograde axon cargo transport 1 1 0 0.00941326 GO:0016034 maleylacetoacetate isomerase activity 1 1 0 0.00941326 GO:0016939 kinesin II complex 1 1 0 0.00941326 GO:0019987 negative regulation of anti-apoptosis 1 1 0 0.00941326 GO:0030325 adrenal gland development 1 1 0 0.00941326 GO:0045023 G0 to G1 transition 56 4537 42.7 0.00951181 GO:0003824 catalytic activity 7 264 2.4 0.0124574 GO:0016567 protein ubiquitination 7 268 2.5 0.0134394 GO:0000151 ubiquitin ligase complex 68 5837 54.9 0.0136475 GO:0008152 metabolism 14 771 7.2 0.0137666 GO:0016772 transferase activity, transferring phosphorus-containing groups 2 21 0.1 0.0164294 GO:0000082 G1/S transition of mitotic cell cycle 2 21 0.1 0.0164294 GO:0008287 protein serine/threonine phosphatase complex 11 559 5.2 0.0164609 GO:0016310 phosphorylation 7 286 2.6 0.0185551 GO:0007028 cytoplasm organization and biogenesis 1 2 0 0.0187386 GO:0000209 protein polyubiquitination 1 2 0 0.0187386 GO:0001672 regulation of chromatin assembly/disassembly 1 2 0 0.0187386 GO:0001786 phosphatidylserine binding 1 2 0 0.0187386 GO:0004020 adenylyl-sulfate kinase activity 1 2 0 0.0187386 GO:0004779 sulfate adenylyltransferase activity 1 2 0 0.0187386 GO:0004781 sulfate adenylyltransferase (ATP) activity 1 2 0 0.0187386 GO:0008429 phosphatidylethanolamine binding 1 2 0 0.0187386 GO:0030517 negative regulation of axon extension 1 2 0 0.0187386 GO:0042177 negative regulation of protein catabolism 1 2 0 0.0187386 GO:0045646 regulation of erythrocyte differentiation 1 2 0 0.0187386 GO:0045648 positive regulation of erythrocyte differentiation 3 62 0.5 0.0206011 GO:0004840 ubiquitin conjugating enzyme activity 3 62 0.5 0.0206011 GO:0008639 small protein conjugating enzyme activity 2 24 0.2 0.0212007 GO:0030100 regulation of endocytosis 91 8414 79.2 0.0213451 GO:0007582 physiological process 2 25 0.2 0.0229041 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 28 2048 19.2 0.0249694 GO:0050789 regulation of biological process 4 118 1.1 0.0252866 GO:0000278 mitotic cell cycle 35 2707 25.4 0.0261658 GO:0005737 cytoplasm 2 27 0.2 0.0264732 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2 27 0.2 0.0264732 GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity 6 243 2.2 0.0274034 GO:0042578 phosphoric ester hydrolase activity 6 244 2.2 0.0278848 GO:0006996 organelle organization and biogenesis 1 3 0 0.0279768 GO:0000320 re-entry into mitotic cell cycle 1 3 0 0.0279768 GO:0004652 polynucleotide adenylyltransferase activity 1 3 0 0.0279768 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1 3 0 0.0279768 GO:0004828 serine-tRNA ligase activity 1 3 0 0.0279768 GO:0005869 dynactin complex 1 3 0 0.0279768 GO:0006434 seryl-tRNA aminoacylation 1 3 0 0.0279768 GO:0042147 retrograde transport, endosome to Golgi 1 3 0 0.0279768 GO:0043149 stress fiber formation 1 3 0 0.0279768 GO:0045806 negative regulation of endocytosis 1 3 0 0.0279768 GO:0048041 focal adhesion formation 3 70 0.6 0.0282529 GO:0006816 calcium ion transport 4 128 1.2 0.032748 GO:0004721 phosphoprotein phosphatase activity 4 131 1.2 0.0352121 GO:0003774 motor activity 5 1147 10.7 0.0358654 u GO:0005215 transporter activity 1 4 0 0.0371286 GO:0000103 sulfate assimilation 1 4 0 0.0371286 GO:0003997 acyl-CoA oxidase activity 1 4 0 0.0371286 GO:0006791 sulfur utilization 1 4 0 0.0371286 GO:0007435 salivary gland morphogenesis 1 4 0 0.0371286 GO:0008088 axon cargo transport 1 4 0 0.0371286 GO:0009895 negative regulation of catabolism 1 4 0 0.0371286 GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors 1 4 0 0.0371286 GO:0045639 positive regulation of myeloid blood cell differentiation 1 4 0 0.0371286 GO:0045767 regulation of anti-apoptosis 4 139 1.3 0.0422969 GO:0030695 GTPase regulator activity 5 204 1.9 0.0436868 GO:0007010 cytoskeleton organization and biogenesis 3 84 0.7 0.044774 GO:0007017 microtubule-based process 1 5 0 0.0461949 GO:0000145 exocyst 1 5 0 0.0461949 GO:0004287 prolyl oligopeptidase activity 1 5 0 0.0461949 GO:0006572 tyrosine catabolism 1 5 0 0.0461949 GO:0006910 phagocytosis, recognition 1 5 0 0.0461949 GO:0007044 cell-substrate junction assembly 1 5 0 0.0461949 GO:0017137 Rab interactor activity 1 5 0 0.0461949 GO:0030516 regulation of axon extension 1 5 0 0.0461949 GO:0030865 cortical cytoskeleton organization and biogenesis 1 5 0 0.0461949 GO:0030866 cortical actin cytoskeleton organization and biogenesis 10 582 5.4 0.0480885 GO:0016043 cell organization and biogenesis 2 38 0.3 0.049601 GO:0007018 microtubule-based movement 2 38 0.3 0.049601 GO:0030705 cytoskeleton-dependent intracellular transport 5 212 1.9 0.0500528 GO:0016192 vesicle-mediated transport 4 149 1.4 0.0522055 GO:0006974 response to DNA damage stimulus 1 6 0 0.0551765 GO:0001658 ureteric bud branching 1 6 0 0.0551765 GO:0001725 stress fiber 1 6 0 0.0551765 GO:0003756 protein disulfide isomerase activity 1 6 0 0.0551765 GO:0006559 phenylalanine catabolism 1 6 0 0.0551765 GO:0007270 nerve-nerve synaptic transmission 1 6 0 0.0551765 GO:0007431 salivary gland development 1 6 0 0.0551765 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1 6 0 0.0551765 GO:0042176 regulation of protein catabolism 1 6 0 0.0551765 GO:0042577 lipid phosphatase activity 1 6 0 0.0551765 GO:0051051 negative regulation of transport 22 3170 29.8 0.0590446 u GO:0007154 cell communication 4 157 1.4 0.0609687 GO:0009719 response to endogenous stimulus 3 97 0.9 0.0635375 GO:0006397 mRNA processing 1 7 0 0.0640742 GO:0005388 calcium-transporting ATPase activity 1 7 0 0.0640742 GO:0006558 L-phenylalanine metabolism 1 7 0 0.0640742 GO:0006564 L-serine biosynthesis 1 7 0 0.0640742 GO:0009074 aromatic amino acid family catabolism 1 7 0 0.0640742 GO:0015085 calcium ion transporter activity 1 7 0 0.0640742 GO:0045444 adipocyte differentiation 1 7 0 0.0640742 GO:0051017 actin filament bundle formation 3 102 0.9 0.0715802 GO:0045202 synapse 1 8 0 0.0728887 GO:0005871 kinesin complex 1 8 0 0.0728887 GO:0006635 fatty acid beta-oxidation 1 8 0 0.0728887 GO:0006911 phagocytosis, engulfment 1 8 0 0.0728887 GO:0007595 lactation 1 8 0 0.0728887 GO:0008601 protein phosphatase type 2A regulator activity 1 8 0 0.0728887 GO:0015035 protein disulfide oxidoreductase activity 1 8 0 0.0728887 GO:0019905 syntaxin binding 1 8 0 0.0728887 GO:0030218 erythrocyte differentiation 1 8 0 0.0728887 GO:0030659 cytoplasmic vesicle membrane 5 238 2.2 0.0743294 GO:0016070 RNA metabolism 7 390 3.6 0.0755198 GO:0007155 cell adhesion 2 49 0.4 0.0776655 GO:0005789 endoplasmic reticulum membrane 2 49 0.4 0.0776655 GO:0051049 regulation of transport 3 106 0.9 0.0783273 GO:0016071 mRNA metabolism 2 50 0.4 0.0804191 GO:0042175 nuclear envelope-endoplasmic reticulum network 1 9 0 0.0816208 GO:0000086 G2/M transition of mitotic cell cycle 1 9 0 0.0816208 GO:0000781 chromosome, telomeric region 1 9 0 0.0816208 GO:0007004 telomerase-dependent telomere maintenance 1 9 0 0.0816208 GO:0009618 response to pathogenic bacteria 1 9 0 0.0816208 GO:0009894 regulation of catabolism 1 9 0 0.0816208 GO:0016581 NuRD complex 1 9 0 0.0816208 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1 9 0 0.0816208 GO:0019439 aromatic compound catabolism 2 51 0.4 0.0832027 GO:0005941 unlocalized 3 110 1 0.0853422 GO:0006470 protein amino acid dephosphorylation 3 110 1 0.0853422 GO:0015674 di-, tri-valent inorganic cation transport 3 112 1 0.0889472 GO:0006357 regulation of transcription from Pol II promoter 3 112 1 0.0889472 GO:0016311 dephosphorylation 1 10 0 0.0902712 GO:0000159 protein phosphatase type 2A complex 1 10 0 0.0902712 GO:0001763 branching morphogenesis 1 10 0 0.0902712 GO:0004685 calcium/calmodulin-dependent protein kinase activity 1 10 0 0.0902712 GO:0005178 integrin binding 1 10 0 0.0902712 GO:0005913 cell-cell adherens junction 1 10 0 0.0902712 GO:0006563 L-serine metabolism 1 10 0 0.0902712 GO:0009070 serine family amino acid biosynthesis 1 10 0 0.0902712 GO:0016358 dendrite morphogenesis 1 10 0 0.0902712 GO:0042060 wound healing 2 54 0.5 0.0917259 GO:0000375 RNA splicing, via transesterification reactions 2 54 0.5 0.0917259 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2 54 0.5 0.0917259 GO:0000398 nuclear mRNA splicing, via spliceosome 8 491 4.6 0.0922679 GO:0007049 cell cycle 4 185 1.7 0.0972769 GO:0006396 RNA processing 3 117 1.1 0.0982335 GO:0006897 endocytosis 1 11 0.1 0.0988408 GO:0000149 SNARE binding 1 11 0.1 0.0988408 GO:0001657 ureteric bud development 1 11 0.1 0.0988408 GO:0004550 nucleoside-diphosphate kinase activity 1 11 0.1 0.0988408 GO:0004602 glutathione peroxidase activity 1 11 0.1 0.0988408 GO:0005158 insulin receptor binding 1 11 0.1 0.0988408 GO:0005802 Golgi trans face 1 11 0.1 0.0988408 GO:0006183 GTP biosynthesis 1 11 0.1 0.0988408 GO:0006228 UTP biosynthesis 1 11 0.1 0.0988408 GO:0006241 CTP biosynthesis 1 11 0.1 0.0988408 GO:0008645 hexose transport 1 11 0.1 0.0988408 GO:0009208 pyrimidine ribonucleoside triphosphate metabolism 1 11 0.1 0.0988408 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthesis 1 11 0.1 0.0988408 GO:0009218 pyrimidine ribonucleotide metabolism 1 11 0.1 0.0988408 GO:0009220 pyrimidine ribonucleotide biosynthesis 1 11 0.1 0.0988408 GO:0015749 monosaccharide transport 1 11 0.1 0.0988408 GO:0015758 glucose transport 1 11 0.1 0.0988408 GO:0042472 inner ear morphogenesis 1 11 0.1 0.0988408 GO:0046036 CTP metabolism 1 11 0.1 0.0988408 GO:0046039 GTP metabolism 1 11 0.1 0.0988408 GO:0046051 UTP metabolism 1 11 0.1 0.0988408 GO:0051052 regulation of DNA metabolism 4 187 1.7 0.10019 GO:0016791 phosphoric monoester hydrolase activity 3 119 1.1 0.102054 GO:0007243 protein kinase cascade 2 59 0.5 0.10646 GO:0008081 phosphoric diester hydrolase activity 1 12 0.1 0.10733 GO:0004179 membrane alanyl aminopeptidase activity 1 12 0.1 0.10733 GO:0006570 tyrosine metabolism 1 12 0.1 0.10733 GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1 12 0.1 0.10733 GO:0016284 alanine aminopeptidase activity 1 12 0.1 0.10733 GO:0042471 ear morphogenesis 1 12 0.1 0.10733 GO:0050764 regulation of phagocytosis 1 12 0.1 0.10733 GO:0050766 positive regulation of phagocytosis 8 517 4.8 0.114863 GO:0006950 response to stress 2 62 0.5 0.115586 GO:0005096 GTPase activator activity 1 13 0.1 0.11574 GO:0005938 cell cortex 1 13 0.1 0.11574 GO:0006446 regulation of translational initiation 1 13 0.1 0.11574 GO:0007548 sex differentiation 1 13 0.1 0.11574 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 1 13 0.1 0.11574 GO:0016197 endosome transport 1 13 0.1 0.11574 GO:0016998 cell wall catabolism 1 13 0.1 0.11574 GO:0019395 fatty acid oxidation 1 13 0.1 0.11574 GO:0042493 response to drug 1 13 0.1 0.11574 GO:0045121 lipid raft 2 63 0.5 0.118671 GO:0030036 actin cytoskeleton organization and biogenesis 6 358 3.3 0.122092 GO:0015031 protein transport 1 14 0.1 0.124072 GO:0000723 telomere maintenance 1 14 0.1 0.124072 GO:0004683 calmodulin regulated protein kinase activity 1 14 0.1 0.124072 GO:0005924 cell-substrate adherens junction 1 14 0.1 0.124072 GO:0006700 C21-steroid hormone biosynthesis 1 14 0.1 0.124072 GO:0009069 serine family amino acid metabolism 1 14 0.1 0.124072 GO:0012506 vesicle membrane 1 14 0.1 0.124072 GO:0045807 positive regulation of endocytosis 5 280 2.6 0.124752 GO:0005794 Golgi apparatus 3 132 1.2 0.128261 GO:0006520 amino acid metabolism 48 5831 54.8 0.12877 u GO:0009987 cellular process 2 67 0.6 0.131211 GO:0008380 RNA splicing 2 67 0.6 0.131211 GO:0030029 actin filament-based process 1 15 0.1 0.132325 GO:0004722 protein serine/threonine phosphatase activity 1 15 0.1 0.132325 GO:0008207 C21-steroid hormone metabolism 1 15 0.1 0.132325 GO:0008286 insulin receptor signaling pathway 1 15 0.1 0.132325 GO:0045637 regulation of myeloid blood cell differentiation 1 16 0.1 0.140502 GO:0005520 insulin-like growth factor binding 1 16 0.1 0.140502 GO:0006289 nucleotide-excision repair 1 16 0.1 0.140502 GO:0007059 chromosome segregation 1 16 0.1 0.140502 GO:0030055 cell-matrix junction 1 16 0.1 0.140502 GO:0030176 integral to endoplasmic reticulum membrane 18 1458 13.7 0.140573 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 19 1564 14.7 0.147397 GO:0019222 regulation of metabolism 3 141 1.3 0.147662 GO:0000287 magnesium ion binding 1 17 0.1 0.148601 GO:0000118 histone deacetylase complex 1 17 0.1 0.148601 GO:0007032 endosome organization and biogenesis 1 17 0.1 0.148601 GO:0016323 basolateral plasma membrane 6 384 3.6 0.154316 GO:0030234 enzyme regulator activity 1 18 0.1 0.156626 GO:0001656 metanephros development 1 18 0.1 0.156626 GO:0001822 kidney development 1 18 0.1 0.156626 GO:0004437 inositol/phosphatidylinositol phosphatase activity 1 18 0.1 0.156626 GO:0007015 actin filament organization 1 18 0.1 0.156626 GO:0042446 hormone biosynthesis 1 18 0.1 0.156626 GO:0051050 positive regulation of transport 3 146 1.3 0.15883 GO:0006366 transcription from Pol II promoter 22 1874 17.6 0.160294 GO:0046872 metal ion binding 17 1393 13.1 0.160415 GO:0006355 regulation of transcription, DNA-dependent 1 19 0.1 0.164575 GO:0001655 urogenital system development 1 19 0.1 0.164575 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1 19 0.1 0.164575 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1 19 0.1 0.164575 GO:0009072 aromatic amino acid family metabolism 1 19 0.1 0.164575 GO:0030286 dynein complex 30 2670 25.1 0.165111 GO:0005634 nucleus 1 20 0.1 0.172449 GO:0006909 phagocytosis 1 20 0.1 0.172449 GO:0045597 positive regulation of cell differentiation 3 152 1.4 0.172562 GO:0000067 DNA replication and chromosome cycle 19 1606 15.1 0.175043 GO:0050791 regulation of physiological process 1 333 3.1 0.175105 u GO:0015267 channel/pore class transporter activity 17 1417 13.3 0.177646 GO:0006351 transcription, DNA-dependent 18 1516 14.2 0.179672 GO:0006350 transcription 2 82 0.7 0.180502 GO:0008202 steroid metabolism 3 157 1.4 0.184256 GO:0012505 endomembrane system 1 325 3 0.185654 u GO:0015268 alpha-type channel activity 1 22 0.2 0.187978 GO:0004364 glutathione transferase activity 1 22 0.2 0.187978 GO:0006221 pyrimidine nucleotide biosynthesis 1 22 0.2 0.187978 GO:0019901 protein kinase binding 3 160 1.5 0.191372 GO:0003779 actin binding 5 327 3 0.195378 GO:0005783 endoplasmic reticulum 1 23 0.2 0.195634 GO:0005905 coated pit 1 23 0.2 0.195634 GO:0009063 amino acid catabolism 8 594 5.5 0.19719 GO:0016788 hydrolase activity, acting on ester bonds 1 24 0.2 0.203218 GO:0003777 microtubule motor activity 1 24 0.2 0.203218 GO:0006112 energy reserve metabolism 1 24 0.2 0.203218 GO:0006953 acute-phase response 1 24 0.2 0.203218 GO:0007338 fertilization (sensu Animalia) 1 24 0.2 0.203218 GO:0009566 fertilization 1 24 0.2 0.203218 GO:0015082 di-, tri-valent inorganic cation transporter activity 1 24 0.2 0.203218 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1 24 0.2 0.203218 GO:0019888 protein phosphatase regulator activity 1 24 0.2 0.203218 GO:0019900 kinase binding 1 24 0.2 0.203218 GO:0019933 cAMP-mediated signaling 17 1452 13.6 0.204427 GO:0045449 regulation of transcription 2 90 0.8 0.207806 GO:0008047 enzyme activator activity 3 167 1.5 0.208238 GO:0006519 amino acid and derivative metabolism 1 25 0.2 0.210731 GO:0007249 I-kappaB kinase/NF-kappaB cascade 1 25 0.2 0.210731 GO:0008017 microtubule binding 1 25 0.2 0.210731 GO:0009617 response to bacteria 2 92 0.8 0.214703 GO:0005083 small GTPase regulatory/interacting protein activity 1 26 0.2 0.218174 GO:0019208 phosphatase regulator activity 1 301 2.8 0.22074 u GO:0005216 ion channel activity 2 433 4 0.221271 u GO:0005102 receptor binding 1 27 0.2 0.225547 GO:0008643 carbohydrate transport 8 619 5.8 0.228196 GO:0008283 cell proliferation 1 28 0.2 0.232851 GO:0004177 aminopeptidase activity 1 28 0.2 0.232851 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1 28 0.2 0.232851 GO:0019935 cyclic-nucleotide-mediated signaling 4 262 2.4 0.233606 GO:0019752 carboxylic acid metabolism 1 293 2.7 0.233655 u GO:0005975 carbohydrate metabolism 5 350 3.2 0.234166 GO:0006629 lipid metabolism 4 265 2.4 0.239682 GO:0006082 organic acid metabolism 1 29 0.2 0.240087 GO:0009310 amine catabolism 3 181 1.7 0.242879 GO:0009308 amine metabolism 1 30 0.2 0.247255 GO:0015631 tubulin binding 2 102 0.9 0.249446 GO:0006511 ubiquitin-dependent protein catabolism 2 102 0.9 0.249446 GO:0019941 modification-dependent protein catabolism 1 31 0.2 0.254356 GO:0015036 disulfide oxidoreductase activity 1 31 0.2 0.254356 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity 1 31 0.2 0.254356 GO:0019838 growth factor binding 1 31 0.2 0.254356 GO:0050876 reproductive physiological process 1 32 0.3 0.26139 GO:0005912 adherens junction 1 32 0.3 0.26139 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1 33 0.3 0.268359 GO:0003702 RNA polymerase II transcription factor activity 1 33 0.3 0.268359 GO:0005200 structural constituent of cytoskeleton 1 33 0.3 0.268359 GO:0016860 intramolecular oxidoreductase activity 1 34 0.3 0.275262 GO:0006887 exocytosis 1 34 0.3 0.275262 GO:0008203 cholesterol metabolism 1 34 0.3 0.275262 GO:0008652 amino acid biosynthesis 1 34 0.3 0.275262 GO:0016859 cis-trans isomerase activity 29 2750 25.8 0.277718 GO:0008151 cell growth and/or maintenance 6 872 8.2 0.279242 u GO:0009058 biosynthesis 22 2672 25.1 0.282685 u GO:0003676 nucleic acid binding 12 1058 9.9 0.293244 GO:0050896 response to stimulus 18 1656 15.5 0.293774 GO:0006810 transport 1 37 0.3 0.295586 GO:0005319 lipid transporter activity 1 37 0.3 0.295586 GO:0007411 axon guidance 1 37 0.3 0.295586 GO:0019932 second-messenger-mediated signaling 83 9173 86.3 0.299372 u GO:0005623 cell 4 620 5.8 0.300541 u GO:0006811 ion transport 25 2374 22.3 0.301397 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1 38 0.3 0.302234 GO:0016125 sterol metabolism 1 38 0.3 0.302234 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2 119 1.1 0.308728 GO:0009790 embryonic development 1 39 0.3 0.30882 GO:0005543 phospholipid binding 1 39 0.3 0.30882 GO:0006418 tRNA aminoacylation for protein translation 1 39 0.3 0.30882 GO:0030099 myeloid blood cell differentiation 1 39 0.3 0.30882 GO:0042445 hormone metabolism 1 39 0.3 0.30882 GO:0043038 amino acid activation 1 39 0.3 0.30882 GO:0043039 tRNA aminoacylation 15 1372 12.9 0.309777 GO:0016740 transferase activity 1 40 0.3 0.315345 GO:0000165 MAPKKK cascade 1 40 0.3 0.315345 GO:0006445 regulation of translation 2 121 1.1 0.315665 GO:0016853 isomerase activity 5 724 6.8 0.317355 u GO:0009059 macromolecule biosynthesis 2 122 1.1 0.319128 GO:0007268 synaptic transmission 1 41 0.3 0.321808 GO:0003682 chromatin binding 1 41 0.3 0.321808 GO:0004812 tRNA ligase activity 1 41 0.3 0.321808 GO:0006694 steroid biosynthesis 1 41 0.3 0.321808 GO:0008201 heparin binding 1 41 0.3 0.321808 GO:0008452 RNA ligase activity 1 41 0.3 0.321808 GO:0016875 ligase activity, forming carbon-oxygen bonds 1 41 0.3 0.321808 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 6 496 4.6 0.324812 GO:0050794 regulation of cellular process 1 42 0.3 0.32821 GO:0006400 tRNA modification 1 42 0.3 0.32821 GO:0006413 translational initiation 1 42 0.3 0.32821 GO:0006986 response to unfolded protein 1 42 0.3 0.32821 GO:0030145 manganese ion binding 2 125 1.1 0.329491 GO:0006281 DNA repair 6 500 4.7 0.33149 GO:0005509 calcium ion binding 3 480 4.5 0.333609 u GO:0006952 defense response 4 596 5.6 0.334199 u GO:0003700 transcription factor activity 1 43 0.4 0.334553 GO:0006790 sulfur metabolism 12 1095 10.3 0.334849 GO:0008270 zinc ion binding 9 797 7.5 0.335933 GO:0009056 catabolism 2 127 1.1 0.336377 GO:0043037 translation 17 1604 15 0.339385 GO:0003677 DNA binding 2 128 1.2 0.339812 GO:0019226 transmission of nerve impulse 2 128 1.2 0.339812 GO:0050905 neuromuscular physiological process 1 44 0.4 0.340836 GO:0000122 negative regulation of transcription from Pol II promoter 1 44 0.4 0.340836 GO:0007420 brain development 1 238 2.2 0.34094 u GO:0042623 ATPase activity, coupled 2 129 1.2 0.343242 GO:0006260 DNA replication 2 130 1.2 0.346667 GO:0015629 actin cytoskeleton 1 46 0.4 0.353226 GO:0009795 embryonic morphogenesis 4 321 3 0.357664 GO:0046907 intracellular transport 1 47 0.4 0.359334 GO:0005262 calcium channel activity 1 47 0.4 0.359334 GO:0009145 purine nucleoside triphosphate biosynthesis 1 47 0.4 0.359334 GO:0009201 ribonucleoside triphosphate biosynthesis 1 47 0.4 0.359334 GO:0009206 purine ribonucleoside triphosphate biosynthesis 1 47 0.4 0.359334 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1 47 0.4 0.359334 GO:0016886 ligase activity, forming phosphoric ester bonds 1 47 0.4 0.359334 GO:0045211 postsynaptic membrane 1 230 2.1 0.359437 u GO:0015672 monovalent inorganic cation transport 13 1221 11.4 0.363268 GO:0046914 transition metal ion binding 2 346 3.2 0.36375 u GO:0016265 death 1 48 0.4 0.365385 GO:0008235 metalloexopeptidase activity 1 48 0.4 0.365385 GO:0009897 external side of plasma membrane 1 48 0.4 0.365385 GO:0019897 extrinsic to plasma membrane 2 136 1.2 0.367085 GO:0016779 nucleotidyltransferase activity 2 343 3.2 0.369628 u GO:0008219 cell death 1 49 0.4 0.371379 GO:0009451 RNA modification 1 49 0.4 0.371379 GO:0019898 extrinsic to membrane 3 456 4.2 0.373598 u GO:0004175 endopeptidase activity 1 224 2.1 0.373816 u GO:0015075 ion transporter activity 7 625 5.8 0.374375 GO:0005198 structural molecule activity 1 221 2 0.381169 u GO:0005261 cation channel activity 1 51 0.4 0.3832 GO:0005615 extracellular space 1 51 0.4 0.3832 GO:0009142 nucleoside triphosphate biosynthesis 1 51 0.4 0.3832 GO:0009199 ribonucleoside triphosphate metabolism 1 51 0.4 0.3832 GO:0009205 purine ribonucleoside triphosphate metabolism 1 51 0.4 0.3832 GO:0016042 lipid catabolism 1 51 0.4 0.3832 GO:0046873 metal ion transporter activity 1 218 2 0.388631 u GO:0006886 intracellular protein transport 2 144 1.3 0.393921 GO:0050793 regulation of development 3 444 4.1 0.394674 u GO:0006412 protein biosynthesis 1 53 0.4 0.394799 GO:0006869 lipid transport 1 53 0.4 0.394799 GO:0009144 purine nucleoside triphosphate metabolism 1 53 0.4 0.394799 GO:0009309 amine biosynthesis 1 53 0.4 0.394799 GO:0019899 enzyme binding 1 214 2 0.398752 u GO:0009117 nucleotide metabolism 6 776 7.3 0.399255 u GO:0030528 transcription regulator activity 1 54 0.5 0.400518 GO:0005777 peroxisome 1 54 0.5 0.400518 GO:0042579 microbody 7 884 8.3 0.402537 u GO:0050874 organismal physiological process 1 55 0.5 0.406182 GO:0004221 ubiquitin thiolesterase activity 1 55 0.5 0.406182 GO:0004725 protein tyrosine phosphatase activity 1 55 0.5 0.406182 GO:0007160 cell-matrix adhesion 1 211 1.9 0.406471 u GO:0004518 nuclease activity 1 211 1.9 0.406471 u GO:0009581 detection of external stimulus 7 879 8.2 0.409057 u GO:0009605 response to external stimulus 1 56 0.5 0.411794 GO:0005539 glycosaminoglycan binding 1 56 0.5 0.411794 GO:0009152 purine ribonucleotide biosynthesis 1 56 0.5 0.411794 GO:0016563 transcriptional activator activity 2 151 1.4 0.41698 GO:0007267 cell-cell signaling 1 57 0.5 0.417353 GO:0004843 ubiquitin-specific protease activity 1 57 0.5 0.417353 GO:0015992 proton transport 1 58 0.5 0.42286 GO:0001558 regulation of cell growth 1 58 0.5 0.42286 GO:0005730 nucleolus 1 58 0.5 0.42286 GO:0006818 hydrogen transport 1 58 0.5 0.42286 GO:0006916 anti-apoptosis 1 204 1.9 0.424908 u GO:0007264 small GTPase mediated signal transduction 1 204 1.9 0.424908 u GO:0009628 response to abiotic stimulus 18 1795 16.8 0.425082 GO:0016787 hydrolase activity 1 59 0.5 0.428315 GO:0005635 nuclear membrane 1 59 0.5 0.428315 GO:0009260 ribonucleotide biosynthesis 7 660 6.2 0.428751 GO:0007242 intracellular signaling cascade 2 313 2.9 0.43189 u GO:0012501 programmed cell death 2 311 2.9 0.436259 u GO:0005386 carrier activity 1 199 1.8 0.438441 u GO:0003735 structural constituent of ribosome 3 420 3.9 0.43887 u GO:0006955 immune response 1 61 0.5 0.439072 GO:0006164 purine nucleotide biosynthesis 2 309 2.9 0.440655 u GO:0006915 apoptosis 1 198 1.8 0.441184 u GO:0000074 regulation of cell cycle 3 259 2.4 0.441766 GO:0007399 neurogenesis 1 197 1.8 0.443939 u GO:0007600 sensory perception 1 62 0.5 0.444375 GO:0007417 central nervous system development 1 62 0.5 0.444375 GO:0009150 purine ribonucleotide metabolism 5 634 5.9 0.446513 u GO:0005886 plasma membrane 1 63 0.5 0.449629 GO:0007409 axonogenesis 1 63 0.5 0.449629 GO:0016568 chromatin modification 2 162 1.5 0.452305 GO:0004713 protein-tyrosine kinase activity 1 64 0.6 0.454833 GO:0003743 translation initiation factor activity 1 65 0.6 0.459988 GO:0006399 tRNA metabolism 1 65 0.6 0.459988 GO:0015293 symporter activity 14 1415 13.3 0.463982 GO:0007275 development 2 166 1.5 0.464852 GO:0006457 protein folding 1 66 0.6 0.465094 GO:0009259 ribonucleotide metabolism 1 66 0.6 0.465094 GO:0043066 negative regulation of apoptosis 1 66 0.6 0.465094 GO:0043069 negative regulation of programmed cell death 3 270 2.5 0.468771 GO:0005578 extracellular matrix 1 67 0.6 0.470153 GO:0045892 negative regulation of transcription, DNA-dependent 4 375 3.5 0.471869 GO:0003723 RNA binding 1 68 0.6 0.475165 GO:0003924 GTPase activity 6 723 6.8 0.47523 u GO:0005576 extracellular 3 399 3.7 0.479592 u GO:0006812 cation transport 1 69 0.6 0.480129 GO:0006163 purine nucleotide metabolism 1 69 0.6 0.480129 GO:0016790 thiolester hydrolase activity 1 69 0.6 0.480129 GO:0045045 secretory pathway 4 505 4.7 0.481567 u GO:0006259 DNA metabolism 1 70 0.6 0.485047 GO:0045595 regulation of cell differentiation 7 698 6.5 0.487196 GO:0009887 organogenesis 1 71 0.6 0.489918 GO:0042625 ATPase activity, coupled to transmembrane movement of ions 30 3131 29.4 0.49008 GO:0050875 cellular physiological process 1 180 1.6 0.492594 u GO:0000267 cell fraction 1 72 0.6 0.494744 GO:0016049 cell growth 6 599 5.6 0.497491 GO:0016491 oxidoreductase activity 1 178 1.6 0.49854 u GO:0007276 gametogenesis 1 74 0.6 0.50426 GO:0001501 skeletal development 1 176 1.6 0.504531 u GO:0004857 enzyme inhibitor activity 3 286 2.6 0.506987 GO:0005525 GTP binding 1 75 0.7 0.508951 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 1 75 0.7 0.508951 GO:0008361 regulation of cell size 2 181 1.7 0.510361 GO:0007001 chromosome organization and biogenesis (sensu Eukarya) 1 174 1.6 0.510566 u GO:0043067 regulation of programmed cell death 8 822 7.7 0.513524 GO:0009653 morphogenesis 6 610 5.7 0.515358 GO:0030163 protein catabolism 2 183 1.7 0.516238 GO:0050879 organismal movement 1 172 1.6 0.516646 u GO:0042981 regulation of apoptosis 2 276 2.5 0.516741 u GO:0030529 ribonucleoprotein complex 5 590 5.5 0.517284 u GO:0006508 proteolysis and peptidolysis 1 171 1.6 0.519703 u GO:0005654 nucleoplasm 6 613 5.7 0.520191 GO:0009057 macromolecule catabolism 1 78 0.7 0.522762 GO:0040008 regulation of growth 1 170 1.6 0.522771 u GO:0008324 cation transporter activity 3 294 2.7 0.525564 GO:0019001 guanyl nucleotide binding 3 294 2.7 0.525564 GO:0030154 cell differentiation 1 169 1.5 0.525849 u GO:0008236 serine-type peptidase activity 1 79 0.7 0.527279 GO:0007517 muscle development 1 79 0.7 0.527279 GO:0009966 regulation of signal transduction 2 187 1.7 0.527852 GO:0006997 nuclear organization and biogenesis 3 297 2.7 0.532433 GO:0030001 metal ion transport 6 622 5.8 0.53458 GO:0008233 peptidase activity 1 166 1.5 0.535148 u GO:0005840 ribosome 1 81 0.7 0.536187 GO:0000087 M phase of mitotic cell cycle 1 81 0.7 0.536187 GO:0007067 mitosis 5 578 5.4 0.537169 u GO:0009607 response to biotic stimulus 1 165 1.5 0.538269 u GO:0005624 membrane fraction 1 82 0.7 0.540578 GO:0009986 cell surface 1 83 0.7 0.544928 GO:0007156 homophilic cell adhesion 1 83 0.7 0.544928 GO:0008238 exopeptidase activity 1 162 1.5 0.547695 u GO:0015290 electrochemical potential-driven transporter activity 6 632 5.9 0.550359 GO:0005739 mitochondrion 1 161 1.5 0.550857 u GO:0015291 porter activity 1 85 0.8 0.553505 GO:0015405 P-P-bond-hydrolysis-driven transporter activity 1 159 1.4 0.557212 u GO:0006066 alcohol metabolism 1 86 0.8 0.557734 GO:0006725 aromatic compound metabolism 1 158 1.4 0.560405 u GO:0006323 DNA packaging 1 158 1.4 0.560405 u GO:0006325 establishment and/or maintenance of chromatin architecture 1 158 1.4 0.560405 u GO:0006928 cell motility 1 158 1.4 0.560405 u GO:0008237 metallopeptidase activity 1 87 0.8 0.561922 GO:0009147 pyrimidine nucleoside triphosphate metabolism 1 157 1.4 0.563607 u GO:0004252 serine-type endopeptidase activity 2 200 1.8 0.56429 GO:0005829 cytosol 1 88 0.8 0.566072 GO:0006417 regulation of protein biosynthesis 2 203 1.9 0.57241 GO:0000003 reproduction 2 203 1.9 0.57241 GO:0019953 sexual reproduction 1 91 0.8 0.578287 GO:0004867 serine-type endopeptidase inhibitor activity 2 250 2.3 0.580703 u GO:0016887 ATPase activity 1 92 0.8 0.582282 GO:0006631 fatty acid metabolism 1 92 0.8 0.582282 GO:0009889 regulation of biosynthesis 3 348 3.2 0.584666 u GO:0016817 hydrolase activity, acting on acid anhydrides 2 209 1.9 0.588322 GO:0005694 chromosome 1 94 0.8 0.590161 GO:0006220 pyrimidine nucleotide metabolism 3 345 3.2 0.591037 u GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 148 1.3 0.592851 u GO:0008289 lipid binding 1 95 0.8 0.594045 GO:0007283 spermatogenesis 1 95 0.8 0.594045 GO:0048232 male gamete generation 1 96 0.9 0.597892 GO:0005911 intercellular junction 1 96 0.9 0.597892 GO:0008135 translation factor activity, nucleic acid binding 1 146 1.3 0.599448 u GO:0009611 response to wounding 1 97 0.9 0.601703 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3 337 3.1 0.608085 u GO:0006118 electron transport 1 99 0.9 0.609218 GO:0045182 translation regulator activity 1 141 1.3 0.616086 u GO:0008610 lipid biosynthesis 2 235 2.2 0.618745 u GO:0009613 response to pest/pathogen/parasite 1 140 1.3 0.619437 u GO:0005244 voltage-gated ion channel activity 1 102 0.9 0.620227 GO:0009165 nucleotide biosynthesis 1 102 0.9 0.620227 GO:0019866 inner membrane 1 139 1.3 0.622795 u GO:0016023 cytoplasmic vesicle 1 103 0.9 0.623828 GO:0016481 negative regulation of transcription 1 103 0.9 0.623828 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1 106 0.9 0.634429 GO:0005667 transcription factor complex 1 106 0.9 0.634429 GO:0016477 cell migration 1 135 1.2 0.636302 u GO:0000902 cellular morphogenesis 1 132 1.2 0.646502 u GO:0030414 protease inhibitor activity 3 319 3 0.646623 u GO:0050877 neurophysiological process 1 131 1.2 0.649915 u GO:0004866 endopeptidase inhibitor activity 1 131 1.2 0.649915 u GO:0015399 primary active transporter activity 1 130 1.2 0.653333 u GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1 129 1.2 0.656758 u GO:0009141 nucleoside triphosphate metabolism 1 127 1.1 0.663623 u GO:0009892 negative regulation of metabolism 1 127 1.1 0.663623 u GO:0042626 ATPase activity, coupled to transmembrane movement of substances 1 125 1.1 0.670509 u GO:0019012 virion 1 124 1.1 0.673959 u GO:0019028 viral capsid 1 123 1.1 0.677413 u GO:0005489 electron transporter activity 1 123 1.1 0.677413 u GO:0042221 response to chemical substance 1 120 1.1 0.687802 u GO:0006091 energy pathways 1 119 1.1 0.691272 u GO:0030054 cell junction 1 118 1.1 0.694745 u GO:0007167 enzyme linked receptor protein signaling pathway 1 117 1.1 0.698222 u GO:0008234 cysteine-type peptidase activity 1 115 1 0.705183 u GO:0000279 M phase 1 114 1 0.708667 u GO:0015980 energy derivation by oxidation of organic compounds 1 113 1 0.712154 u GO:0016337 cell-cell adhesion 1 113 1 0.712154 u GO:0040007 growth 1 111 1 0.719131 u GO:0016327 apicolateral plasma membrane 1 110 1 0.722622 u GO:0000280 nuclear division 1 108 1 0.729606 u GO:0006333 chromatin assembly/disassembly 1 107 1 0.733098 u GO:0030097 hemopoiesis 1 107 1 0.733098 u GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism